Arf6 as a therapeutic target: Structure, mechanism, and inhibitors
Acta Pharmaceutica Sinica B, 2023 ADP-ribosylation factor 6 (Arf6), a small G-protein of the Ras superfamily, plays pivotal roles in multiple cellular events, including exocytosis, endocytosis, actin remodeling, plasma membrane reorganization and vesicular transport.
Lixia Chen, Dejuan Sun
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The Potential Target Value of ADP-Ribosylation Factor 6 in Insulin Secretion Regulation and the Treatment of Metabolic Disorders [PDF]
MetabolitesObesity and type 2 diabetes mellitus (T2DM) represent pandemic metabolic illnesses hallmarked by defective pancreatic β-cell function and blunted insulin release.
Yangyang Wang
doaj +2 more sources
Tissue‐specific targeting of the ARF6 signalling axis for type 2 diabetes and obesity: From mechanism to nanodelivery [PDF]
Clinical and Translational MedicineDisorders of glucose metabolism, particularly type 2 diabetes and obesity, remain major therapeutic challenges because they involve dysfunction across multiple tissues, including pancreatic β‐cells, peripheral insulin‐sensitive tissues, and immune cells.
Yangyang Wang +3 more
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Identification and validation of ARF6 for a potential prognostic biomarker of acute myeloid leukemia [PDF]
Cancer Cell InternationalBackground The small GTPase ADP-ribosylation factor 6 (ARF6) is key in cell membrane transport and cytoskeleton remodeling. It has been proven to drive the occurrence and development of a variety of tumors. The subject of this study is to investigate the
Chike Zhang +8 more
doaj +2 more sources
The small GTPase ARF6 regulates sphingolipid homeostasis and supports proliferation in acute myeloid leukemia [PDF]
HaematologicaMetabolic dependencies are emerging as promising therapy targets in cancer, including acute myeloid leukemia (AML). Several metabolic vulnerabilities have been identified in AML cells, including a requirement for balanced sphingolipid metabolism to ...
Helong Gary Zhao +14 more
doaj +2 more sources
Methuosis key gene ARF6 as a diagnostic, prognostic and immunotherapeutic marker for prostate cancer: based on a comprehensive pan-cancer multi-omics analysis [PDF]
Discover OncologyBackground Prostate cancer (PCa) is a leading cause of cancer-related mortality among men worldwide. Despite progress in the understanding of tumor biology, the prognosis for advanced prostate cancer remains poor, necessitating the identification of ...
Yongjin Yang +5 more
doaj +2 more sources
Arf GTPases Define BST-2-Independent Pathways for HIV-1 Assembly and Release [PDF]
VirusesADP-ribosylation factor (Arf) proteins are small GTPases that regulate intracellular membrane trafficking and actin remodeling through tightly controlled cycles of GTP binding and hydrolysis.
Adam Smith +4 more
doaj +2 more sources
ARF6 promotes hepatocellular carcinoma proliferation through activating STAT3 signaling
Cancer Cell International, 2023 Background Hepatocellular Carcinoma (HCC) possesses the high mortality in cancers worldwide. Nevertheless, the concrete mechanism underlying HCC proliferation remains obscure.
Yabing Hu +5 more
doaj +1 more source
PLoS ONE, 2022 ADP-ribosylation factor 6 small GTPase plays an important role in cell migration, invasion and angiogenesis, which are the hallmarks of cancer. Although alterations in ARF6 expression and activity have been linked to metastatic cancer in one or two ...
Venkateswarlu Kanamarlapudi +2 more
doaj +1 more source
ARF6 regulates neuron differentiation through glucosylceramide synthase. [PDF]
PLoS ONE, 2013 The small GTPase ADP ribosylation factor 6 (ARF6) mediates endocytosis and has in addition been shown to regulate neuron differentiation. Here we investigated whether ARF6 promotes differentiation of Neuro-2a neuronal cells by modifying the cellular ...
Lu Li +7 more
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