Results 31 to 40 of about 9,646 (208)
Scientific Reports, 2022 Hormones and growth factors stimulate vascular smooth muscle cells (VSMC) invasive capacities during the progression of atherosclerosis. The GTPase ARF6 is an important regulator of migration and proliferation of various cell types, but whether this ...
Emilie Fiola-Masson +3 more
doaj +1 more source
Arf6 arbitrates fibrinogen endocytosis
Blood, 2016 In this issue of Blood, in a departure from studies of classic platelet function, Huang et al turn their attention to endocytosis and show that adenosine 5′-diphosphate-ribosylation factor 6 (Arf6) plays a key role in fibrinogen engulfment. Although platelets are known to bind, absorb, and load their granules with plasma proteins, this report is one of
Matthew T. Rondina, Andrew S. Weyrich
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Endocytosis of hERG Is Clathrin-Independent and Involves Arf6 [PDF]
PLoS ONE, 2013 The hERG potassium channel is critical for repolarisation of the cardiac action potential. Reduced expression of hERG at the plasma membrane, whether caused by hereditary mutations or drugs, results in long QT syndrome and increases the risk of ventricular arrhythmias.
Karnik, Rucha +6 more
openaire +5 more sources
VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis
Cell Reports, 2023 Summary: Clinical sequencing efforts are rapidly identifying sarcoma gene fusions that lack functional validation. An example is the fusion of transcriptional coactivators, VGLL2-NCOA2, found in infantile rhabdomyosarcoma.
Sarah Watson +16 more
doaj +1 more source
Inhibition of cell migration by PITENINs: the role of ARF6 [PDF]
Oncogene, 2011 We have reported previously the development of small-molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including activation of Akt, and show anti-tumor potential. Here we show that the same molecules inhibit growth factor-induced actin remodeling, lamellipodia formation ...
Miao, Benchun +9 more
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Low oscillatory shar stress Arf6 heterozygosity decreases Arf6 expression.
, 2023 (A) Gene expression of Arf6 in unligated (right) and partially ligated (left) carotid arteries, (B,C) Gene expression fo Arf from endothelial cell (EC) enriched and vascular smooth muscle cell (VSMC) enriched carotid artery lysates from wildtype (WT) and
Daniel W. Trott (15447440) +9 more
core +1 more source
Cell Communication and Signaling, 2021 Many clinical trials are being conducted to clarify effective combinations of various drugs for immune checkpoint blockade (ICB) therapy. However, although extensive studies from multiple aspects have been conducted regarding treatments for pancreatic ...
Ari Hashimoto +7 more
doaj +1 more source
Arf6 determines tissue architecture by stabilizing intercellular adhesion [PDF]
, 2020 Correct cell shape is indispensable for tissue architecture, with cell shape being determined by cortical actin and surface adhesion. The role of adhesion in remodeling tissue is to counteract the deformation of cells by force, resulting from actomyosin ...
Bulgakova, N. +3 more
core +1 more source
Cell motility: ARNOand ARF6 at the cutting edge [PDF]
Current Biology, 2001 The transition of epithelial cells from a stationary to a motile state is important in embryogenesis, wound repair and metastasis. Recent studies have shown that ARNO and ARF6 play significant roles in coordinating this transition, providing new insight into the interplay between the Rho and ARF families of GTPases.
Turner, Christopher E, Brown, Michael C
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ARF6 protein expression increase in EAC.
, 2022 (A) Cancer stage-dependent expression of ARF6 mRNA in the oesophagus. (B) Immunostaining of EAC TMA was performed in a benchmark Ultra IHC staining module with an anti-ARF6 antibody.
Venkateswarlu Kanamarlapudi (311218) +2 more
core +1 more source