Results 51 to 60 of about 9,646 (208)
Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6 [PDF]
, 2018 Endogenous sphingolipids (ceramide) and related synthetic molecules (FTY720, SH-BC-893) reduce nutrient access by decreasing cell surface expression of a subset of nutrient transporter proteins.
Liu, Gang +25 more
core +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu +3 more
wiley +1 more source
ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles [PDF]
, 2009 SummaryBackgroundIncreased mitogen-activated protein kinase (MAPK) signaling, small GTPase activation, cytoskeletal rearrangements, and the directed targeting of proteases to sites of extracellular matrix degradation all accompany the process of tumor ...
Clancy, James +6 more
core +1 more source
mBio, 2015 Entry into cells is critical for virulence of the human bacterial pathogens Shigella spp. Shigella spp. induce membrane ruffle formation and macropinocytic uptake, but the events instigating this process are incompletely understood. The host small GTPase
Anna Cristina Garza-Mayers +4 more
doaj +1 more source
Cell Communication and Signaling, 2023 Mutations in the KRAS gene and overexpression of protein products of the MYC and ARF6 genes occur frequently in cancer. Here, the inseparable relationships and cooperation of the protein products of these three genes in cancer malignancy and immune ...
Hisataka Sabe
doaj +1 more source
Secretopathies emerge as a new class of neurocristopathies
Developmental Dynamics, EarlyView.Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira +3 more
wiley +1 more source
ARF6 controls Ang II-induced Rac1 activation.
, 2016 VSMC were stimulated for the indicated times with Ang II (100 nM) then lysed. (A). Endogenous levels of activated ARF6 (ARF6-GTP) captured by GST pulldown assay and total ARF6 (input) were assessed by Western blot analysis (n = 4, *P P < 0.01).
Mohamed Bourmoum (2176606) +2 more
core +1 more source
MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions
Immunology, EarlyView.MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula +6 more
wiley +1 more source
ARF6 and Rab11 as intrinsic regulators of axon regeneration [PDF]
Small GTPases, 2018 Adult central nervous system (CNS) axons do not regenerate after injury because of extrinsic inhibitory factors, and a low intrinsic capacity for axon growth. Developing CNS neurons have a better regenerative ability, but lose this with maturity. This mini-review summarises recent findings which suggest one reason for regenerative failure is the ...
Nieuwenhuis, Bart, Eva, Richard
openaire +4 more sources
Journal of Immunology Research, 2015 Phagocytosis of zymosan by phagocytes is a widely used model of microbial recognition by the innate immune system. Live-cell imaging showed that fluorescent protein-fused Rab35 accumulated in the membranes of phagocytic cups and then dissociated from the
Youhei Egami +5 more
doaj +1 more source