Results 71 to 80 of about 9,646 (208)

ARF6 Promotes AML Progression via Activation of PI3K/AKT/mTOR Signaling

Cancer Medicine
Background Acute myeloid leukemia (AML) represents a highly aggressive hematological malignancy characterized by a poor prognosis and a pressing demand for innovative diagnostic and prognostic biomarkers.
Haitao Xu, Dangui Chen, Jia Lu, Long Zhong, Lihong Wang, Jian Ge   +5 more
doaj   +1 more source

The role of MHC class I recycling and Arf6 in cross-presentation by murine dendritic cells

Life Science Alliance, 2019
MHC-I internalization and recycling in DCs neither requires Arf6 nor provides MHC-I to the Rab11+ endocytic recycling compartment; however, cross-presentation of immune complexes depends on Arf6.
Sebastian Montealegre, Anastasia Abramova, Valerie Manceau, Anne-Floor de Kanter, Peter van Endert   +4 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Loss of Pdlim7 results in unbalanced Arf6-GDP / GTP ratios.

, 2016
(A) Western-blot analysis using anti-Pdlim7 antibodies of washed platelets from WT and Pdlim7-/- mice demonstrates presence of Pdlim7 proteins in WT, but not Pdlim7-/- platelet lysates (Pdlim7). Anti-Arf6 antibodies detected similar amounts of total Arf6
Alexander E. Urban (195065), Erin O. Quick (3280707), Kaylie P. Miller (3280704), Hans-Georg Simon (108477), Jennifer Krcmery (108451)   +4 more
core   +1 more source

A Role for ARF6 and ARNO in the Regulation of Endosomal Dynamics in Neurons [PDF]

Traffic, 2007
During development, neuronal processes extend, branch and navigate to ultimately synapse with target tissue. We have shown a regulatory role for ARNO and ARF6 in dendritic branching and axonal elongation and branching during neuritogenesis, particularly with respect to cytoskeletal dynamics.
Hernandez-Deviez, Delia, Mackay-Sim, Alan, Wilson, Jean M   +2 more
openaire   +4 more sources

Heterozygosity for ADP-ribosylation factor 6 suppresses the burden and severity of atherosclerosis.

PLoS ONE, 2023
Atherosclerosis is the root cause of major cardiovascular diseases (CVD) such as myocardial infarction and stroke. ADP-ribosylation factor 6 (Arf6) is a ubiquitously expressed GTPase known to be involved in inflammation, vascular permeability and is ...
Venkateswara R Gogulamudi, Md Torikul Islam, Jessica R Durrant, Adelola O Adeyemo, Daniel W Trott, Mi Ho Hyuhn, Weiquan Zhu, Anthony J Donato, Ashley E Walker, Lisa A Lesniewski   +9 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, Volume 600, Issue 17, Page 2564-2578, September 2026.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The GTPase ARF6 Controls ROS Production to Mediate Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation. [PDF]

PLoS ONE, 2016
High reactive oxygen species (ROS) levels and enhanced vascular smooth muscle cells (VSMC) proliferation are observed in numerous cardiovascular diseases.
Mohamed Bourmoum, Ricardo Charles, Audrey Claing   +2 more
doaj   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, Volume 15, Issue 36, 25 September 2026.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Molecular Mechanisms and Therapeutic Applications of Extracellular Vesicles in Remodeling of the Skin Cancer Niche

Nano Select, Volume 7, Issue 9, September 2026.
Extracellular vesicles at the nexus of skin cancer progression and precision therapy. EVs orchestrate tumor microenvironment remodeling through cargo‐mediated intercellular communication, immune modulation, angiogenesis, and extracellular matrix reorganization, while also emerging as next‐generation platforms for targeted drug delivery, biomarker ...
Megha Kotian, Maria Nison, Deepanjan Datta, Soniya Kumbham, Namdev Dhas, Praveen Halagali, Vasudev R Pai, Vamshi Krishna Tippavajhala   +7 more
wiley   +1 more source