Results 81 to 90 of about 9,646 (208)

High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer

Cell Communication and Signaling, 2020
Background Not merely the onset of immune evasion, but other factors, such as acidosis and fibrosis, are also major barriers in cancer therapeutics. Dense fibrosis is a hallmark of pancreatic ductal carcinoma (PDAC), in which hyperactivation of focal ...
Akio Tsutaho, Ari Hashimoto, Shigeru Hashimoto, Soichiro Hata, Shion Kachi, Satoshi Hirano, Hisataka Sabe   +6 more
doaj   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, Volume 293, Issue 17, Page 5340-5362, September 2026.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

ARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C disease.

PLoS ONE, 2009
In human Niemann-Pick Type C (NPC) disease, endosomal trafficking defects lead to an accumulation of free cholesterol and other lipids in late endosome/lysosome (LE/LY) compartments, a subsequent block in cholesterol esterification and significantly ...
Jill Kuglin Schweitzer, Sean D Pietrini, Crislyn D'Souza-Schorey   +2 more
doaj   +1 more source

GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis. [PDF]

PLoS ONE, 2011
Angiogenesis and cancer invasiveness greatly contribute to cancer malignancy.Arf6 and its effector, AMAP1, are frequently overexpressed in breast cancer, and constitute a central pathway to induce the invasion and metastasis.
Ari Hashimoto, Shigeru Hashimoto, Ryo Ando, Kosuke Noda, Eiji Ogawa, Hirokazu Kotani, Mayumi Hirose, Toshi Menju, Masaki Morishige, Toshiaki Manabe, Yoshinobu Toda, Susumu Ishida, Hisataka Sabe   +12 more
doaj   +1 more source

The pathogenic effector PHYL1JWB interacts with ZjCURT1A to mediate jujube witches' broom‐induced photosynthesis impairment of jujube trees

The Plant Journal, Volume 127, Issue 5, September 2026.
SUMMARY Photosynthesis impairment and the accompanying leaf yellowing represent a prominent and physiologically critical symptom of phytoplasma infection. However, the underlying molecular mechanisms remain poorly understood. In this study, we identified the Jujube Witches' Broom pathogenic effector PHYL1JWB, which was previously reported to induce ...
Fangfang Huang, Changfeng Ai, Chong Yang, Jie Feng, Meng Yang, Li Dai, Chaoling Xue, Hongtai Li, Jiaxue Cui, Xiangjie Qu, Jin Zhao, Mengjun Liu, Xuan Zhao, Zhiguo Liu   +13 more
wiley   +1 more source

Regulation of Arf6 and ACAP1 Signaling by the PTB-Domain-Containing Adaptor Protein GULP [PDF]

, 2007
SummaryThe GTPase Arf6 regulates multiple cellular processes, including endocytosis, secretion, phagocytosis, cell adhesion, and cell migration [1, 2]. The Arf6-specific GAP ACAP1 is a negative regulator of Arf6-mediated signaling [3–7].
Luo, Ruibai, Casanova, James E., Ravichandran, Kodi S., Nie, Zhongzhen, Ma, Zhong   +4 more
core   +1 more source

The small GTPase Arf6 is dysregulated in a mouse model for fragile X syndrome [PDF]

, 2020
Fragile X syndrome (FXS), the most common inherited cause of intellectual disability, results from silencing of the Fragile X mental retardation gene 1 (FMR1).
Du, D., Kornau, H., Elagabani, M., Köhr, G., Briševac, D., Scholz, R.   +5 more
core   +1 more source

ADP-ribosylation factor 6 mediates E-cadherin recovery by chemical chaperones. [PDF]

PLoS ONE, 2011
E-cadherin plays a powerful tumor suppressor role. Germline E-cadherin mutations justify 30% of Hereditary Diffuse Gastric Cancer (HDGC) and missense mutations are found in 30% of these families.
Joana Figueiredo, Joana Simões-Correia, Ola Söderberg, Gianpaolo Suriano, Raquel Seruca   +4 more
doaj   +1 more source

Molecular mechanisms underlying seed enlargement mediated by seed coat development in autotetraploid castor bean

The Plant Journal, Volume 127, Issue 6, September 2026.
SUMMARY Polyploids, particularly synthetic lines, often produce larger seeds than their diploid progenitors. However, little is known regarding the role of seed coat development in the larger seeds formation in polyploid plants. Here, we investigated the cellular and molecular basis by which seed coat development mediates seed enlargement in the ...
Dan He, Tianlong Yang, Xianxing Chen, Xueyong Xu, Chen Liu, Anmin Yu, Bing Han, Aizhong Liu, Jian Wu   +8 more
wiley   +1 more source

Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model

Cell Communication and Signaling, 2018
Background The small GTPase Arf6 and its downstream effector AMAP1 (also called ASAP1/DDEF1) constitute a signaling pathway promoting cell invasion, in which AMAP1 interacts with several different proteins, including PRKD2, EPB41L5, paxillin, and ...
Yutaro Otsuka, Tsukasa Oikawa, Hinako Yoshino, Shigeru Hashimoto, Haruka Handa, Hiroki Yamamoto, Ari Hashimoto, Hisataka Sabe   +7 more
doaj   +1 more source