Results 61 to 70 of about 9,646 (208)

GEP100/Arf6 is required for epidermal growth factor-induced ERK/Rac1 signaling and cell migration in human hepatoma HepG2 cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Epidermal growth factor (EGF) signaling is implicated in the invasion and metastasis of hepatoma cells. However, the signaling pathways for EGF-induced motility of hepatoma cells remain undefined. METHODOLOGY/PRINCIPAL FINDINGS: We found that
ZhenZhen Hu, Jun Du, Ling Yang, YiChao Zhu, Yu Yang, DaTong Zheng, Akimasa Someya, Luo Gu, Xiang Lu   +8 more
doaj   +1 more source

In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells

Experimental Physiology, EarlyView.
Abstract Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide variability in EPS protocols hampers reproducibility and cross‐study comparisons.
Mark R. C. van de Meene, Anita M. van den Hoek, Roeland Hanemaaijer, Lars Verschuren, Jelle C. B. C. de Jong   +4 more
wiley   +1 more source

CLIC4/Arf6 Pathway.

Circulation research, 2019
Increased expression of CLIC4 (chloride intracellular channel 4) is a feature of endothelial dysfunction in pulmonary arterial hypertension, but its role in disease pathology is not fully understood.To identify CLIC4 effectors and evaluate strategies targeting CLIC4 signaling in pulmonary hypertension.Proteomic analysis of CLIC4-interacting proteins in
Vahitha B, Abdul-Salam, Giusy, Russomanno, Chen, Chien-Nien, Abdul S, Mahomed, Luke A, Yates, Martin R, Wilkins, Lan, Zhao, Magdalena, Gierula, Oliver, Dubois, Ute, Schaeper, Jens, Endruschat, Beata, Wojciak-Stothard   +11 more
openaire   +4 more sources

Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes

JCI Insight, 2021
Asthma is a chronic inflammatory disease of the airways associated with excess production of Th2 cytokines and lung eosinophil accumulation. This inflammatory response persists in spite of steroid administration that blocks autocrine/paracrine loops of ...
SangJoon Lee, Akari Ishitsuka, Takahiro Kuroki, Yu-Hsien Lin, Akira Shibuya, Tsunaki Hongu, Yuji Funakoshi, Yasunori Kanaho, Kyosuke Nagata, Atsushi Kawaguchi   +9 more
doaj   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Arf6 wins the MVP award [PDF]

Journal of Cell Biology, 2016
The mevalonate pathway drives cancer metastasis and drug resistance by promoting the activation of Arf6.
openaire   +1 more source

Requirement for Arf6 in breast cancer invasive activities [PDF]

Proceedings of the National Academy of Sciences, 2004
In most human breast cancer cell lines, there is a direct correlation between their in vivo invasive phenotypes and in vitro invasion activities. Here, we found that ADP-ribosylation factor 6 (Arf6) is localized at the invadopodia of the cultured breast
Shigeru, Hashimoto, Yasuhito, Onodera, Ari, Hashimoto, Miwa, Tanaka, Michinari, Hamaguchi, Atsuko, Yamada, Hisataka, Sabe   +6 more
openaire   +2 more sources

ARF6 is important for the differentiation of Neuro-2a cells.

, 2013
(A–D) Neuro-2a cells were transfected with control (c) or ARF6 siRNA in medium with 10% FCS and analyzed after 48 h. (A) ARF6 protein levels in cell lysate after siRNA treatment.
Linda Andersson (396279), Marcus Ståhlman (119836), Jan Borén (119843), Mikael Rutberg (396277), Liliana Håversen (312956), Malin Levin (396280), Lu Li (14069), Per Fogelstrand (396278)   +7 more
core   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

AUXIN RESPONSE FACTORs: from transcription factors to auxin effectors

New Phytologist, Volume 252, Issue 2, Page 607-613, October 2026.
Molecular evolution of AUXIN RESPONSE FACTOR (ARF) effector function. Summary Signalling pathways have originated and diversified extensively during evolution. Using AUXIN RESPONSE FACTORs (ARFs) as a model, we examine how a plant signalling system evolved through the co‐option of pre‐existing transcriptional regulators, a principle well established in
Melissa Dipp‐Álvarez, Jorge Hernández‐García   +1 more
wiley   +1 more source