Results 21 to 30 of about 9,646 (208)
Targeting ARF6-SUCNR1 Axis: Antisense Oligonucleotide Adjuvants for Neutrophil Immunometabolism. [PDF]
Int J Mol SciConventional vaccine adjuvants often lack cell-type specificity and readily trigger excessive systemic inflammation, limiting their clinical application.
Wang Y, Chen Y.
europepmc +2 more sources
A role for ARF6 in dendritic cell podosome formation and migration
European Journal of Immunology, 2008 ADP-ribosylation factor 6 (ARF6) is a widely expressed GTPase that influences both membrane traffic and actin cytoskeleton function. Its role in dendritic cells (DC) has not previously been investigated. We analysed the effect of retroviral expression of
Watts, Colin +11 more
core +4 more sources
Biology Open, 2021 Wnt signalling is a core pathway involved in a wide range of developmental processes throughout the metazoa. In vitro studies have suggested that the small GTP binding protein Arf6 regulates upstream steps of Wnt transduction, by promoting the ...
Julien Marcetteau +3 more
doaj +1 more source
Acta Biochimica et Biophysica Sinica, 2022 ERK1/2 are essential proteins mediating mitogen-activated protein kinase signaling downstream of RAS in pancreatic adenocarcinoma (PDAC). Our previous study reveals that ARF6 plays a positive regulatory role in ERK1/2 pathway in a feedback loop manner. A
Xiao Bingkai +10 more
doaj +1 more source
Arf6 Regulation of Gyrating‐Clathrin [PDF]
Traffic, 2012 ‘Gyrating‐’ or ‘G’‐clathrin are coated endocytic structures located near peripheral sorting endosomes (SEs), which exhibit highly dynamic but localized movements when visualized by live‐cell microscopy. They have been implicated in recycling of transferrin from the sorting endosome directly to the cell surface, but there is no information about their ...
Yi, Luo, Yi, Zhan, James H, Keen
openaire +2 more sources
The Small GTPase Arf6 Functions as a Membrane Tether in a Chemically-Defined Reconstitution System
Frontiers in Cell and Developmental Biology, 2021 Arf-family small GTPases are essential protein components for membrane trafficking in all eukaryotic endomembrane systems, particularly during the formation of membrane-bound, coat protein complex-coated transport carriers.
Kana Fujibayashi, Joji Mima
doaj +1 more source
Molecules, 2021 Breast cancer is a major disease for women worldwide, where mortality is associated with tumour cell dissemination to distant organs. While the number of efficient anticancer therapies increased in the past 20 years, treatments targeting the invasive ...
Eric Macia +9 more
doaj +1 more source
CCL18 promotes breast cancer progression by exosomal miR-760 activation of ARF6/Src/PI3K/Akt pathway
Molecular Therapy: Oncolytics, 2022 The small GTPase ADP-ribosylation factor 6 (ARF6) mediates chemokine (C-C motif) ligand 18 (CCL18)-induced activation of breast cancer (BC) metastasis through its downstream effector AMAP1. However, the molecular mechanisms underlying CCL18 up-regulating
Xiaojia Huang +8 more
doaj +1 more source
ARNO is recruited by the neuronal adaptor FE65 to potentiate ARF6-mediated neurite outgrowth
Open Biology, 2022 ADP-ribosylation factor 6 (ARF6) is a small GTPase that has a variety of neuronal functions including stimulating neurite outgrowth, a crucial process for the establishment and maintenance of neural connectivity.
Yuqi Zhai +3 more
doaj +1 more source
Mediators of Inflammation, 2020 Chemoattractant sensing, adhesiveness, and migration are critical events underlying the recruitment of neutrophils (PMNs) to sites of inflammation or infection. Defects in leukocyte adhesion or migration result in immunodeficiency disorders characterized
Jouda Gamara +7 more
doaj +1 more source