Results 11 to 20 of about 9,646 (208)

The Role of ARF6 in Biliary Atresia. [PDF]

PLoS ONE, 2015
Altered extrahepatic bile ducts, gut, and cardiovascular anomalies constitute the variable phenotype of biliary atresia (BA).To identify potential susceptibility loci, Caucasian children, normal (controls) and with BA (cases) at two US centers were ...
Mylarappa Ningappa, Juhoon So, Joseph Glessner, Chethan Ashokkumar, Sarangarajan Ranganathan, Jun Min, Brandon W Higgs, Qing Sun, Kimberly Haberman, Lori Schmitt, Silvia Vilarinho, Pramod K Mistry, Gerard Vockley, Anil Dhawan, George K Gittes, Hakon Hakonarson, Ronald Jaffe, Shankar Subramaniam, Donghun Shin, Rakesh Sindhi   +19 more
doaj   +6 more sources

ARF6 mediates nephrin tyrosine phosphorylation-induced podocyte cellular dynamics.

PLoS ONE, 2017
ADP-ribosylation factor 6 (ARF6) is a small GTPase necessary for regulating cellular structure, motility, and vesicle trafficking. In several cellular systems, ARF6 was shown to regulate actin dynamics in coordination with Rac1, a Rho small GTPase.
Jamie S Lin, Jin Seok Jeon, Qingfeng Fan, Hetty N Wong, Matthew B Palmer, Lawrence B Holzman   +5 more
doaj   +2 more sources

ARF6-dependent interaction of the TWIK1 K(+) channel with EFA6, a GDP/GTP exchange factor for ARF6. [PDF]

The EMBO Reports, 2004
TWIK1 belongs to a family of K+ channels involved in neuronal excitability and cell volume regulation. Its tissue distribution suggests a role in epithelial potassium transport.
Richard Warth, Lazdunski, Michel, Bendahhou, Said, Michel Lazdunski, Lazdunski, M., Sebastian Knauer, Michel Franco, Warth, Richard, Sonia Decressac, Decressac, S., Decressac, Sonia, Florian Lesage, Bendahhou, S., Jacques Barhanin, Lesage, Florian, Franco, M., Said Bendahhou, Warth, R., Lesage, F., Knauer, S., Barhanin, Jacques, Franco, Michel, Knauer, Sebastian, Barhanin, J.   +23 more
core   +4 more sources

Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation

BMC Cell Biology, 2007
Background Many studies implicate Arf6 activity in Rac-mediated membrane ruffling and cytoskeletal reorganization. Although Arf6 facilitates the trafficking of Rac1 to the plasma membrane and in many cases Arf6 activation leads to the activation of Rac1,
Donaldson Julie G, Eipper Betty A, Koo Tae   +2 more
doaj   +2 more sources

Fbx8 Makes Arf6 Refractory to Function via Ubiquitination. [PDF]

Molecular Biology of the Cell, 2008
The small GTP-binding protein Arf6 regulates membrane remodeling at cell peripheries and plays crucial roles in higher orders of cellular functions including tumor invasion.
Sabe, Hisataka, Franco, Michel,, Hashimoto, Shigeru, Kobayashi, Itaru, Yano, Hajime, Ronai, Ze'Ev, Onodera, Yasuhito, Luton, Frédéric, Mazaki, Yuichi, Iwai, Kazuhiro   +9 more
core   +3 more sources

Angiotensin II promotes podocyte injury by activating Arf6-Erk1/2-Nox4 signaling pathway.

PLoS ONE, 2020
Angiotensin II (Ang II) is a key contributor to glomerular disease by predominantly resulting in podocyte injury, whereas the underlying molecular mechanisms has not been fully understood.
Guanghua Che, Hang Gao, Qibo Hu, Hongchang Xie, Yunfeng Zhang   +4 more
doaj   +2 more sources

ARF6‐Rac1 signaling‐mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1

The FASEB Journal, 2020
Ras-related C3 botulinum toxin substrate 1 (Rac1) is a member of the Rho family of GTPases that functions as a molecular switch to regulate many important cellular events including actin cytoskeleton remodeling during neurite outgrowth.
Li, W, Lau, KF, Chan, WWR, Chang, RCC
core   +3 more sources

The small GTPase ARF6 regulates GABAergic synapse development [PDF]

Molecular Brain, 2020
ADP ribosylation factors (ARFs) are a family of small GTPases composed of six members (ARF1–6) that control various cellular functions, including membrane trafficking and actin cytoskeletal rearrangement, in eukaryotic cells.
Hyeonho Kim, Hyeji Jung, Hyunsu Jung, Seok-Kyu Kwon, Jaewon Ko, Ji Won Um   +5 more
doaj   +2 more sources

ARF6 and EFA6A regulate the development and maintenance of dendritic spines [PDF]

The Journal of Neuroscience, 2006
The cellular and molecular mechanisms underlying the development and maintenance of dendritic spines are not fully understood. ADP-ribosylation factor 6 ( ARF6) is a small GTPase known to regulate actin remodeling and membrane traffic.
Kim, H, Kim, Eunjoon, Choi, S, Ko, J, Lee, HW, Chung, HS, Kim, K, Lee, JR   +7 more
core   +5 more sources

Arf6 negatively controls the rapid recycling of the β2AR.

Journal of Cell Science, 2012
International audienceβ2-adrenergic receptor (β2AR), a member of the GPCR (G-Proteins Coupled Receptor) family, is internalized in a ligand- and β-arrestin-dependent manner into early endosomes, and subsequently recycled back to the plasma membrane. Here
Partisani, M., Franco, M., Macia, E., Paleotti, O., Luton, F.   +4 more
core   +3 more sources