Results 81 to 90 of about 45,797 (235)
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, Volume 16, Issue 5, Page 870-884, May 2026.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
BMC Cell Biology, 2003 Background Phospholipase D (PLD) is involved in many signaling pathways. In most systems, the activity of PLD is primarily regulated by the members of the ADP-Ribosylation Factor (ARF) family of GTPases, but the mechanism of activation of PLD and ARF by ...
Fluharty Eric +8 more
doaj +1 more source
Advanced Science, Volume 13, Issue 25, 4 May 2026.Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans +8 more
wiley +1 more source
Comprehensive methylome map of lineage commitment from haematopoietic progenitors. [PDF]
, 2010 Epigenetic modifications must underlie lineage-specific differentiation as terminally differentiated cells express tissue-specific genes, but their DNA sequence is unchanged.
Aryee, Martin J +17 more
core +2 more sources
NAD+‒circadian rhythm coupling in dementia
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang +7 more
wiley +1 more source
PLoS Biology, 2006 Fcgamma receptor (FcgammaR)-mediated phagocytosis of IgG-coated particles is regulated by 3'-phosphoinositides (3'PIs) and several classes of small GTPases, including ARF6 from the ADP Ribosylation Factor subfamily.
Peter Beemiller +2 more
doaj +1 more source
Arthritis &Rheumatology, Volume 78, Issue 5, Page 1045-1061, May 2026.Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin +15 more
wiley +1 more source
Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes. [PDF]
, 2019 Poly(ADP-ribose) polymerase 1 (PARP-1) is a multidomain multifunctional nuclear enzyme involved in the regulation of the chromatin structure and transcription.
Ampofo, Michelle +13 more
core +1 more source
Proteomic Analysis of Cervicovaginal Fluid for Diagnostic Endometriosis Biomarker Discovery
PROTEOMICS – Clinical Applications, Volume 20, Issue 3, May 2026.ABSTRACT Purpose Endometriosis is a prevalent inflammatory condition characterised by the presence of endometrial‐like tissue outside the uterus and is associated with significant challenges, including diagnostic delays and continued reliance on laparoscopy.
Emily S. J. Paterson +7 more
wiley +1 more source
Poly(ADP-ribose)polymerase 2 is zinc-dependent enzyme and nucleosome reorganizer
Cellular and Molecular Life SciencesPoly(ADP-ribose)polymerase 2 (PARP2) is a nuclear protein, DNA damage sensor and an emerging target for development of anti-cancer drugs. Previously it was discovered that PARP2 binds to nucleosomes; however, critical factors involved in this process ...
Natalya Maluchenko +8 more
doaj +1 more source