Golgi-localizing, γ-Adaptin Ear Homology Domain, ADP-ribosylation Factor-binding (GGA) Proteins Interact with Acidic Dileucine Sequences within the Cytoplasmic Domains of Sorting Receptors through Their Vps27p/Hrs/STAM (VHS) Domains* [PDF]
Journal of Biological Chemistry, 2001 GGA (Golgi-localizing,γ-adaptin ear homology domain, ARF-binding) proteins are potential effectors of ADP-ribosylation factors, are associated with the trans-Golgi network (TGN), and are involved in protein transport from this compartment.
H. Takatsu +3 more
semanticscholar +2 more sources
ADP-ribosylation factor 6 expression increase in oesophageal adenocarcinoma suggests a potential biomarker role for it. [PDF]
PLoS ONE, 2022 ADP-ribosylation factor 6 small GTPase plays an important role in cell migration, invasion and angiogenesis, which are the hallmarks of cancer. Although alterations in ARF6 expression and activity have been linked to metastatic cancer in one or two ...
Venkateswarlu Kanamarlapudi +2 more
doaj +2 more sources
ADP-ribosylation factor machinery mediates endocytosis in plant cells [PDF]
Proceedings of the National Academy of Sciences, 2010 Endocytosis is crucial for various cellular functions and development of multicellular organisms. In mammals and yeast, ADP-ribosylation factor (ARF) GTPases, key components of vesicle formation, and their regulators ARF-guanine nucleotide exchange factors (GEFs) and ARF-GTPase-activating protein (GAPs) mediate endocytosis.
S. Naramoto +10 more
semanticscholar +3 more sources
Poly-ADP-ribosylation modulated by poly(ADP-ribose) polymerase 1 is associated with glucose metabolism in colorectal cancer cells [PDF]
Translational OncologyThe preference of cancer cells to generate energy from glycolysis for rapid cell proliferation is called the Warburg effect. Poly(ADP-ribose) polymerase 1 (PARP1) performs various cellular functions, including poly-ADP-ribosylation and DNA repair. In the
Chenxuan Zhang +5 more
doaj +2 more sources
Partial Protection of Goats against Haemonchus contortus Achieved with ADP-Ribosylation Factor 1 Encapsulated in PLGA Nanoparticles. [PDF]
Vaccines (Basel)Hasan MW +12 more
europepmc +3 more sources
Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence. [PDF]
PLoS Pathogens, 2010 Candida albicans, the major fungal pathogen of humans, causes life-threatening infections in immunocompromised individuals. Due to limited available therapy options, this can frequently lead to therapy failure and emergence of drug resistance. To improve
Elias Epp +10 more
doaj +6 more sources
Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts.
J Am Soc Nephrol, 2016 Li Y +6 more
europepmc +2 more sources
The interplay of TARG1 and PARG protects against genomic instability
Cell Reports, 2023 Summary: The timely removal of ADP-ribosylation is crucial for efficient DNA repair. However, much remains to be discovered about ADP-ribosylhydrolases. Here, we characterize the physiological role of TARG1, an ADP-ribosylhydrolase that removes aspartate/
Joséphine Groslambert +10 more
doaj +1 more source
The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response
Frontiers in Cell and Developmental Biology, 2021 ADP-ribosylation is a widespread posttranslational modification that is of particular therapeutic relevance due to its involvement in DNA repair. In response to DNA damage, PARP1 and 2 are the main enzymes that catalyze ADP-ribosylation at damage sites ...
Kira Schützenhofer +2 more
doaj +1 more source