Heterozygosity for ADP-ribosylation factor 6 suppresses the burden and severity of atherosclerosis. [PDF]
PLoS ONE, 2023 Atherosclerosis is the root cause of major cardiovascular diseases (CVD) such as myocardial infarction and stroke. ADP-ribosylation factor 6 (Arf6) is a ubiquitously expressed GTPase known to be involved in inflammation, vascular permeability and is ...
Venkateswara R Gogulamudi +9 more
doaj +2 more sources
ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions [PDF]
Frontiers in Cell and Developmental Biology, 2022 Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways.
Tiantian Li +3 more
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Cholesterol 25‐Hydroxylase Protects Against Diabetic Kidney Disease by Regulating ADP Ribosylation Factor 4 [PDF]
Advanced ScienceCholesterol 25‐hydroxylase (CH25H), an enzyme involved in cholesterol metabolism, regulates inflammatory responses and lipid metabolism. However, its role in kidney disease is not known.
Lu Zhang +12 more
doaj +2 more sources
The ADP-Ribosylation Factor 4d Restricts Regulatory T-Cell Induction via Control of IL-2 Availability [PDF]
Cells, 2022 Interleukin-2 is central to the induction and maintenance of both natural (nTreg) and induced Foxp3-expressing regulatory T cells (iTreg). Thus, signals that modulate IL-2 availability may, in turn, also influence Treg homeostasis.
Bernd Geers +9 more
doaj +2 more sources
ADP-ribosylation factor 6 expression increase in oesophageal adenocarcinoma suggests a potential biomarker role for it. [PDF]
PLoS ONE, 2022 ADP-ribosylation factor 6 small GTPase plays an important role in cell migration, invasion and angiogenesis, which are the hallmarks of cancer. Although alterations in ARF6 expression and activity have been linked to metastatic cancer in one or two ...
Venkateswarlu Kanamarlapudi +2 more
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Role of ADP ribosylation factor guanylate kinase 1 in the malignant biological behavior of gastric cancer [PDF]
HeliyonAim: This study aims to investigate the influence of ASAP1 (ADP ribosylation factor guanylate kinase 1) on the malignant behavior of gastric cancer (GC) cells and to elucidate the potential molecular mechanisms involved in cancer development and ...
Qiong Luo +6 more
doaj +2 more sources
PARP7 as a new target for activating anti-tumor immunity in cancer [PDF]
EMBO Molecular MedicineADP-ribosyl transferases (ARTs) are a family of enzymes which catalyze the addition of a chain (PARylation) or a single moiety (MARylation) of ADP-ribose to their substrates.
Katerina Popova +7 more
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Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence [PDF]
PLoS Pathogens, 2010 Peer reviewedPublisher ...
Epp, Elias +10 more
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The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response
Frontiers in Cell and Developmental Biology, 2021 ADP-ribosylation is a widespread posttranslational modification that is of particular therapeutic relevance due to its involvement in DNA repair. In response to DNA damage, PARP1 and 2 are the main enzymes that catalyze ADP-ribosylation at damage sites ...
Kira Schützenhofer +2 more
doaj +1 more source
Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling. [PDF]
PLoS ONE, 2014 Initiation, amplitude, duration and termination of transforming growth factor β (TGFβ) signaling via Smad proteins is regulated by post-translational modifications, including phosphorylation, ubiquitination and acetylation.
Markus Dahl +11 more
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