Results 151 to 160 of about 536,456 (309)

Subclinical cardiac alterations and cardiometabolic profile in adolescents with newly diagnosed polycystic ovary syndrome: A cross‐sectional comparative echocardiographic study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective While cardiometabolic comorbidities have been well established in adults with polycystic ovary syndrome (PCOS), it remains unclear whether the early signs of cardiovascular morbidity emerge during adolescence. This study aimed to investigate whether metabolic and cardiovascular alterations begin in adolescents with PCOS.
Demet Aygün Ari, Melis Pehlivantürk Kizilkan, Musa Öztürk, İlker Ertuğrul, Hayrettin Hakan Aykan, Tevfik Karagöz, Nuray Kanbur, Orhan Derman, Sinem Akgül   +8 more
wiley   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Exploring the Role of Dysregulated Arousal in the Relationship Between Trauma and Addictive Behaviors Among College Students

Journal of Counseling &Development, EarlyView.
ABSTRACT The relationship between trauma and addictive behaviors is well‐established, yet factors mediating this relationship remain understudied. Given the prevalence of addictive behaviors among collegiate populations, we used path analysis to explore the mediating role of arousal dysregulation in the relationship between childhood trauma and a ...
Amanda L. Giordano, Kate M. Dorrough, Deborah L. Smith, Peitao Zhu   +3 more
wiley   +1 more source

From DNA Methylation Microarray to Digital PCR: A Stepwise Strategy for Tissue Specific cfDNA Biomarker Development

Journal of Clinical Laboratory Analysis, EarlyView.
Overview of a DNA methylation biomarker development pipeline, from discovery and assay design to screening, performance evaluation, and specificity testing in clinical sample matrices. ABSTRACT Background Tissue‐specific cell‐free DNA (cfDNA) offers promise as a minimally invasive biomarker of organ injury.
David H. Murray, Nicky Boulter, Shanon Ranjit, Natasha M. Rogers, Sarah Kummerfeld, Jason P. Ross, Rodney J. Scott   +6 more
wiley   +1 more source

Evaluating Brief Behavioural Activation for depression in adolescents with acquired brain injury using a single‐case experimental design

JCPP Advances, EarlyView.
Abstract Background Adolescents who have had an acquired brain injury (ABI) commonly experience depression. Brief Behavioural Activation (Brief BA) is a successful, values‐based intervention for managing depression in neurotypical adolescents. This study investigated the effectiveness of Brief BA, using a single‐case experimental design, with ...
Conor R. O’Brien, Jenny Limond, Shirley Reynolds, Laura Pass, Anna‐Lynne R. Adlam   +4 more
wiley   +1 more source

Interventions for pre‐school children in foster care: A systematic review of the foster carer and system level outcomes from randomised controlled trials

JCPP Advances, EarlyView.
Abstract Background Children in foster care are at increased risk of experiencing cognitive, emotional and behavioural difficulties. There is a window of opportunity for early intervention associated with developmental sensitivity in the early years. Foster carers and the systems supporting them play a central role in intervention and support for the ...
Camilla Biggs, Natalie Kirby, Megan Garside, Gloria Cheung, Fiona Turner, Nishant Jaiswal, Helen Minnis   +6 more
wiley   +1 more source

Adrenocortical Adenocarcinoma in a Syrian Golden Hamster (Mesocricetus auratus) With Suspected Hyperadrenocorticism. [PDF]

Vet Med Sci
Billaux MF, Vieu S, Lecomte A, Cuvelier M, Rohel M, Abadie J, Soetart N.   +6 more
europepmc   +1 more source

Steroidopathies and hormonal imbalance in children and adolescents with autism spectrum disorder

JCPP Advances, EarlyView.
Abstract Background Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with a multifactorial etiology, many aspects of which remain unclear. Emerging evidence suggests a potential association between ASD and clinical manifestations resulting from hormonal imbalances, henceforth named “steroidopathies.” The present study aims to ...
Concetta de Giambattista, Patrizia Ventura, Samuele Cortese, Paolo Trerotoli, Alessandra Di Gioia, Lucia Margari   +5 more
wiley   +1 more source

Miliary tuberculosis with bilateral adrenal involvementand adrenal insufficiency. [PDF]

Rev Soc Bras Med Trop
Yeşilyurt M, Karaman A.
europepmc   +1 more source