Results 231 to 240 of about 536,456 (309)

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan, Candace L. Doepker, Gregory P. Brorby   +2 more
wiley   +1 more source

Safety of 8‐Week Administration With Ashwagandha (Withania somnifera) Root Extract in Adults With Stress and Anxiety: Findings From a Prospective, Randomized, Multi‐Center, Double‐Blinded, Placebo‐Controlled Study

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha (Withania somnifera) has been recognized for enhancing physical strength, mental well‐being, and overall vitality. Despite its long‐standing use across generations, some clinical reports have noted occasional adverse events. This study compared the safety and tolerability of Ashwagandha Root Extract (ARE) in healthy adults.
Ketan Pakhale, Jaising Salve, John Ademola, Jose Parraca, Deepak Langade   +4 more
wiley   +1 more source

Anti‐Allergic Potential of Chamaecrista nomame and Its Compound Luteolin for Novel Asthma Therapy

Phytotherapy Research, EarlyView.
Chamaecrista nomame (CN) and its active compound luteolin attenuate allergic airway inflammation by inhibiting mast cell activation and suppressing NF‐κB/MAPK signaling, leading to reduced cytokine production and OVA‐specific IgE levels. ABSTRACT Asthma is a chronic inflammatory disease driven by dysregulated immune responses and mast cell activation ...
Tae Kyeom Kang, Myungsuk Kim, Tam Thi Le, Geon Park, Yuna Jung, Hyobin Jeong, Youngsang Yoo, Wook‐Bin Lee, Sang Hoon Jung   +8 more
wiley   +1 more source

A Complex Case of Glucose-Phosphate Isomerase Deficiency With an Indeterminate Adrenal Incidentaloma. [PDF]

Cureus
Satheesh Nair G, Sungar NR, Rojed N, Rizvi A, Thiagarajan Srinivasan B.   +4 more
europepmc   +1 more source

Impact of biological/targeted versus conventional synthetic disease‐modifying antirheumatic drugs on patient‐reported outcomes in rheumatoid arthritis

Rheumatology &Autoimmunity, EarlyView.
Patient‐reported outcomes (PROs) were compared among rheumatoid arthritis patients who maintained low disease activity or remission for at least 6 months based on the disease‐modifying antirheumatic drug (DMARD)administered. Even with comparable disease activity, methotrexate (MTX) group, biological/targeted synthetic DMARDs (b/tsDMARDs), particularly ...
Masafumi Sugiyama, Saki Okuda‐Tsuchimoto, Takashi tsuchimoto, Koji Kinoshita, Itaru Matsumura   +4 more
wiley   +1 more source

Neonatal Adrenal Hemorrhage Mimicking Suprarenal Tumor in a 12-Day-Old With <i>Escherichia coli</i> Urosepsis. [PDF]

Case Rep Pediatr
Sawafta K, Abu Hijleh H, Samara Y, Al-Kharraz T.   +3 more
europepmc   +1 more source

Bile acid metabolism and sleep: Mechanistic interplay and clinical implications of the gut–liver–brain axis

Sleep Research, EarlyView.
Abstract The bidirectional interplay between sleep and metabolic homeostasis is fundamental to physiological health. While the roles of glucose and lipid metabolism in sleep regulation have been extensively characterized, bile acids (BAs), which are traditionally viewed as digestive surfactants, are emerging as critical metabolic messengers with ...
Yu Jiang, Shuangyan Li, Dhirendra Paudel, Miaoqin Tan, Bin Zhang   +4 more
wiley   +1 more source

Rapidly Recurrent Retroperitoneal Cystic Lesion With Mass Effect in a Kidney Transplant Recipient: A Diagnostic and Management Challenge. [PDF]

Cureus
Barbosa ML, Samaniego J, Chepuru R, Findley JP, Gebhardt KE, Sestak E, Betman S, Olaitan O.   +7 more
europepmc   +1 more source

Research on sleep quality and influencing factors among medical staff in a tertiary hospital in Anhui Province, China

Sleep Research, EarlyView.
To assess sleep quality and identify key influencing factors among medical staff in a tertiary hospital to support health policy development. Conducted in July 2024 using validated scales: Pittsburgh Sleep Quality Index (PSQI); Depression, Anxiety, and Stress Scale‐21; and Assessed: sleep quality, latency, disturbances, and daytime dysfunction.
Xiao‐Ying Jin, Ting Jiang, Ri‐Hong Wei, Meng‐Dan Chu, Han Li, Shan Zhang, Zeng‐Feng Su   +6 more
wiley   +1 more source