Results 41 to 50 of about 742,426 (338)

Laparoscopic cortical-sparing adrenal surgery in pheochromocytomas associated with hereditary neoplasia syndromes

Endokrynologia Polska, 2020
INTRODUCTION: Pheochromocytomas in hereditary syndromes tend to grow multifocal with adrenal involvement on both sides. Surgical treatment with bilateral adrenalectomy inevitably leads to life-long hormonal dependence, which significantly affects quality
Kornelia Hasse-Lazar, Marcin Zeman, Agnieszka Kotecka-Blicharz, Marta Legutko, Agnieszka Czarniecka, Barbara Michalik, Aleksandra Król, Piotr Szymański, Agnieszka Pawlaczek, Małgorzata Oczko-Wojciechowska, Maciej Grajek, Tomasz Gawlik, Daria Handkiewicz-Junak, Barbara Jarząb   +13 more
doaj   +1 more source

Functional Zonation of the Adult Mammalian Adrenal Cortex

Frontiers in Neuroscience, 2016
The standard model of adrenocortical zonation holds that the three main zones, glomerulosa, fasciculata, and reticularis each have a distinct function, producing mineralocorticoids (in fact just aldosterone), glucocorticoids, and androgens respectively ...
G. Vinson
semanticscholar   +1 more source

Single-cell and spatial transcriptomics analysis of human adrenal aging

Molecular Metabolism
Objective: The human adrenal cortex comprises three functionally and structurally distinct layers that produce layer-specific steroid hormones. With aging, the human adrenal cortex undergoes functional and structural alteration or “adrenal aging ...
Norifusa Iwahashi, Hironobu Umakoshi, Masamichi Fujita, Tazuru Fukumoto, Tatsuki Ogasawara, Maki Yokomoto-Umakoshi, Hiroki Kaneko, Hiroshi Nakao, Namiko Kawamura, Naohiro Uchida, Yayoi Matsuda, Ryuichi Sakamoto, Masahide Seki, Yutaka Suzuki, Kohta Nakatani, Yoshihiro Izumi, Takeshi Bamba, Yoshinao Oda, Yoshihiro Ogawa   +18 more
doaj   +1 more source

Signaling Interactions in the Adrenal Cortex

Frontiers in Endocrinology, 2016
The major physiological stimuli of aldosterone secretion are angiotensin II (AII) and extracellular K+, whereas cortisol production is primarily regulated by corticotropin (ACTH) in fasciculata cells.
A. Spät, L. Hunyady, G. Szanda
semanticscholar   +1 more source

New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study

Arthritis Care &Research, Accepted Article.
Objective Traumatic life events are hypothesized to be triggers for the onset of fibromyalgia. Posttraumatic stress disorder (PTSD) is a common comorbidity of fibromyalgia. However, limited prospective data are available on the development of fibromyalgia after exposure to high magnitude stress.
Jay B. Higgs, Willie J. Hale, Casey L. Straud, Jim Mintz, Stacey Young‐McCaughan, Kimberly D. Gomes, Chelsea J. Sterne, Katrina M. Lawrence‐Wolff, Alan J. Bartholomew, Kevin M. Kelly, Douglas M. Maurer, Catherine Vriend, Brett T. Litz, Douglas E. Williamson, Alan L. Peterson, for the STRONG STAR Consortium   +15 more
wiley   +1 more source

Measurement of the adrenal cortex reserve using depot beta 1-24-corticotrophin. II---in thyroid diseases.

Acta Médica Portuguesa, 1979
Mean plasma cortisol 4 to 6 hours after 1 mg Synacthen Depot in normal subjects, simple goiter and hypothyroidism were not significantly different. On the contrary after stimulation cortisol levels in untreated hyperthyroidism were significantly below ...
A. Galvão-Teles
doaj   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Evaluating the role of aldosterone synthesis on adrenal cell fate

Frontiers in Endocrinology
Hypertension affects one-third of the adult population worldwide, with primary aldosteronism (PA) accounting for at least 5-10% of these cases. The aldosterone synthase enzyme (CYP11B2) plays a pivotal role in PA manifestation, as increased expression of
Amnani Aminuddin, Morris J. Brown, Morris J. Brown, Elena Aisha Azizan, Elena Aisha Azizan, Elena Aisha Azizan   +5 more
doaj   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Double NF1 inactivation affects adrenocortical function in NF1Prx1 mice and a human patient.

PLoS ONE, 2015
BackgroundNeurofibromatosis type I (NF1, MIM#162200) is a relatively frequent genetic condition, which predisposes to tumor formation. Apart from tumors, individuals with NF1 often exhibit endocrine abnormalities such as precocious puberty (2,5-5% of NF1
Karolina Kobus, Daniela Hartl, Claus Eric Ott, Monika Osswald, Angela Huebner, Maja von der Hagen, Denise Emmerich, Jirko Kühnisch, Hans Morreau, Frederik J Hes, Victor F Mautner, Anja Harder, Sigrid Tinschert, Stefan Mundlos, Mateusz Kolanczyk   +14 more
doaj   +1 more source