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New England Journal of Medicine, 2019 Glucocorticoid replacement therapy, available since the 1950s, has prolonged the survival of patients with adrenal insufficiency. However, adrenal crises, which are life-threatening medical emergencies, still develop in many affected patients. Adrenal crisis appears to be increasing in frequency, despite the availability of effective preventive ...
R. Louise Rushworth +2 more
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Adrenal crisis and mortality rate in adrenal insufficiency and congenital adrenal hyperplasia [PDF]
Archives of Endocrinology and Metabolism, 2021 Primary adrenal insufficiency (PAI) is characterized by the inability of the adrenal cortex to produce sufficient amounts of glucocorticoids and/or mineralocorticoids. Addison's disease (AD) and congenital adrenal hyperplasia (CAH) are the most frequent disorders in adults and children, respectively. Despite the diagnostic advances and the availability
Lia Mesquita Lousada +2 more
openaire +7 more sources
Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis [PDF]
Endocrine, 2021 AbstractAdrenal insufficiency (AI) is a life-threatening condition requiring life-long glucocorticoid (GC) substitution therapy, as well as stress adaptation to prevent adrenal crises. The number of individuals with primary and secondary adrenal insufficiency in Europe is estimated to be 20–50/100.000.
Nowotny, Hanna +14 more
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Early Identification and Diagnosis of Adrenal Crisis after Retroperitoneal Laparoscopic Unilateral Adrenalectomy [PDF]
, 2021 The occurrence of adrenal crisis after retroperitoneal laparoscopic unilateral adrenalectomy is usually concealed. If not timely diagnosis and treatment,it may cause shock, and even lead to death.
Cao, Jingzhao +8 more
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Predictors of adrenal crisis in patients with Addison\u27s disease [PDF]
, 2022 Addison\u27s disease is the inability of the adrenal glands to produce cortisol and aldosterone, which must be replaced by medication. During stress or acute illness, there is a risk of adrenal crisis and it is important to adjust the dose of medication.
Cindrić, Tea +6 more
core +2 more sources
Assessment of systemic corticosteroid activity [PDF]
, 1997 The potency of the inhaled corticosteroid, dose, duration of treatment, and the study subject receiving treatment all play a role in the effects observed on the HPA axis.
Dluhy, R.G.
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Increased mortality in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency [PDF]
, 2017 Context: Reports on mortality in patients with congenital adrenal hyperplasia (CAH) are lacking. Objective: To study mortality and causes of death in CAH.
Almqvist, C. +6 more
core +1 more source
Adrenal crises: perspectives and research directions [PDF]
, 2017 Adrenal crises (AC) are life-threatening complications of adrenal insufficiency (AI). These events have an estimated incidence of between 5 and 10 ACs/100 patient years (PY) and are responsible for some of the increased morbidity and excess mortality ...
Falhammar, H, Rushworth, R, Torpy, D
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Glucocorticoid therapy for adrenal insufficiency: nonadherence, concerns and dissatisfaction with information [PDF]
, 2016 Objective: Appropriate self‐management of glucocorticoid therapy (GC) is crucial for patients with adrenal insufficiency (AI). We aimed to describe patients’ self‐reported nonadherence to GC, evaluate perceived doubts about need for GC, concerns about ...
Carroll, P. +3 more
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MedEdPORTAL, 2015 Abstract Introduction Adrenal crisis is a life-threatening emergency requiring immediate treatment with glucocorticoids to avoid morbidity and mortality. The clinical presentation of adrenal crisis is nonspecific and can mimic many other conditions. Simulation can help prepare learners to recognize and treat this emergent condition.
Miriam Kulkarni, Karma Warren
openaire +3 more sources