Results 251 to 260 of about 34,980 (272)

Effectiveness and safety of GLP‐1 receptor agonists in craniopharyngioma patients with obesity: A multicentre real‐world study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Acquired hypothalamic obesity (aHO) following craniopharyngioma (CP) is a challenging condition with limited therapeutic options. This study aimed to assess the real‐world effectiveness and safety of GLP‐1 RAs in this population. Materials and Methods CranioGLP1 is a retrospective multicentre study including 116 adults with aHO treated ...
Flora Lambert, Emilie Guillon, Blandine Gatta‐Cherifi, CranioGLP1_FORCE Group, Flora Lambert, Emilie Guillon, Hedi Soula, Christine Poitou, Pauline Faucher, Frédérique Albarel, Jean‐Baptiste Bonnet, Anne‐Laure Borel, Marie‐Claude Brindisi, Claire Carette, Delphine Drui, Cédric Fagour, Nicolas Farigon, Bénédicte Gaborit, Blandine Gatta‐Cherifi, Fréderic Illouz, Ryme Jouini‐Bouhamri, Ibrahima Maiga, Emilie Montastier, Héléna Mosbah, Géraldine Vitellius, Olivier Ziegler, Hedi Soula, Christine Poitou, Pauline Faucher   +28 more
wiley   +1 more source

Born to run? Associations between gestational and early‐life exposures and later‐life performance outcomes in Thoroughbreds

Equine Veterinary Journal, EarlyView.
Abstract Background Gestational and early‐life exposures may modulate development during growth and influence future athletic performance. Objectives To investigate associations between gestational and early‐life exposures in Thoroughbreds and (i) likelihood of racing, (ii) total number of runs and (iii) total prizemoney by the end of the 3‐year‐old ...
Rebecca Mouncey, Amanda M. de Mestre, Juan Carlos Arango‐Sabogal, Kristien L. Verheyen   +3 more
wiley   +1 more source

Overcoming BET‐inhibitor JQ1 resistance in aggressive non‐small cell lung cancer by inducing ferroptosis via inhibition of the BRD2–FTH1 axis

The FEBS Journal, EarlyView.
Recent studies emphasize alternative functions of FTH1 relevant for nuclear processes, such as transcriptional regulation. This study shows a novel FTH1/BRD2 association in non‐small cell lung carcinoma (NSCLC). This nuclear interaction affects BRD2 protein stability in aggressive NSCLC cells.
Stefania Scicchitano, Cinzia Garofalo, Beatrice Stella, Gianluca Santamaria, Flora Cozzolino, Vittoria Monaco, Flavia Biamonte, Maria Monti, Eleonora Vecchio, Maria Concetta Faniello   +9 more
wiley   +1 more source

In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses

The FEBS Journal, EarlyView.
Gle1 knockout mice fail to segregate cell lineages at the blastocyst stage, resulting in very early embryonic lethality. Gle1 knock‐in (KI) mice harboring a pathogenic variant giving rise to lethal congenital contracture syndrome 1 show both known and novel innervation defects, supportive of multiorgan pathology in human fetuses.
Tomáš Zárybnický, Sonja Lindfors, Saana Metso, Julia Koivula, Zoltan Szabo, Rasmus Valtonen, Mikko Tulppo, Johanna Magga, Samu Saarimäki, Sonja Bläuer, Ilkka Miinalainen, Risto Kerkelä, Petteri. T. Piepponen, Vootele Voikar, Juho Väänänen, Riikka Kivelä, Bhagwan Yadav, Hanna Lindgren, Pirkko Mattila, Fu‐Ping Zhang, Petra Sipilä, Reetta Hinttala, Satu Kuure   +22 more
wiley   +1 more source