Clinical Unmet Needs in the Treatment of Adrenal Crisis: Importance of the Patient’s Perspective
Adrenal crisis is the most severe manifestation of adrenal insufficiency (AI), but AI can present with variable signs and symptoms of gradual severity. Despite current hormone replacement strategies, adrenal crisis is still one of the leading causes of ...
Kim M. J. A. Claessen+3 more
doaj +1 more source
Monitoring for and Management of Endocrine Dysfunction in Adrenoleukodystrophy
Adrenoleukodystrophy (ALD) is a peroxisomal disorder affecting the nervous system, adrenal cortical function, and testicular function. Newborn screening for ALD has the potential to identify patients at high risk for life-threatening adrenal crisis and ...
Isha Kachwala, Molly O. Regelmann
doaj +1 more source
Increased mortality in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency [PDF]
Context: Reports on mortality in patients with congenital adrenal hyperplasia (CAH) are lacking. Objective: To study mortality and causes of death in CAH.
Almqvist, C.+6 more
core +1 more source
Challenging Diagnosis of Addison’s Disease Presenting with Adrenal Crisis
Primary adrenal insufficiency, also known as Addison’s disease, is a rare but potentially fatal condition resulting from the failure of the adrenal cortex to produce glucocorticoid and/or mineralocorticoid hormones.
Ni Wayan Wina Dharmesti+4 more
doaj +1 more source
A Bulking Agent May Lead to Adrenal Insufficiency Crisis: A Case Report [PDF]
Adrenal insufficiency is a life-threatening disorder which must be treated with glucocorticoid replacement and needs permanent dose adjustment during patient's different somatic situations.
Seyed Hossein Samadanifard+4 more
doaj +2 more sources
Glucocorticoid therapy for adrenal insufficiency: nonadherence, concerns and dissatisfaction with information [PDF]
Objective: Appropriate self‐management of glucocorticoid therapy (GC) is crucial for patients with adrenal insufficiency (AI). We aimed to describe patients’ self‐reported nonadherence to GC, evaluate perceived doubts about need for GC, concerns about ...
Carroll, P.+3 more
core +2 more sources
Symptomatic adrenal insufficiency during inhaled corticosteroid treatment [PDF]
Symptomatic adrenal insufficiency, presenting as hypoglycaemia or poor weight gain, may occur on withdrawal of corticosteroid treatment but has not previously been reported during inhaled corticosteroid treatment.
Clayton, P.E.+5 more
core +1 more source
Variations in the management of acute illness in children with congenital adrenal hyperplasia: An audit of three paediatric hospitals [PDF]
Objective: Episodes of acute adrenal insufficiency (AI)/adrenal crises (AC) are a serious consequence of congenital adrenal hyperplasia (CAH). This study aimed to assess morbidity from acute illness in CAH and identify factors associated with use of IV ...
Allolio+25 more
core +2 more sources
Background/Objective: Adrenal crisis is a medical emergency and an acute complication of adrenal insufficiency (AI). It can be triggered by stressors such as infection, dehydration, trauma, or surgery.
Bryan Kuo, MD+2 more
doaj
ObjectiveTo compare cortisol pharmacokinetics and pharmacodynamics mapped through several glucocorticoid sensitive pathways in patients on hydrocortisone substitution with or without an adrenal crisis.DesignA post-hoc analysis of a previously conducted ...
Annet Vulto+3 more
doaj +1 more source