Results 61 to 70 of about 34,336 (287)

Adrenal crisis and mortality rate in adrenal insufficiency and congenital adrenal hyperplasia

Archives of Endocrinology and Metabolism, 2021
Primary adrenal insufficiency (PAI) is characterized by the inability of the adrenal cortex to produce sufficient amounts of glucocorticoids and/or mineralocorticoids.
Lia Mesquita Lousada, Berenice B. Mendonca, Tania A. S. S. Bachega   +2 more
doaj   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

The epidemiology of primary and secondary adrenal malignancies and associated adrenal insufficiency in hospitalised patients: an analysis of hospital admission data, NSW, Australia

BMC Endocrine Disorders, 2021
Background Adrenal insufficiency (AI) causes considerable morbidity but may remain undiagnosed in patients with adrenal malignancy (AM). The epidemiology of AI and adrenal crises (AC) in AM is uncertain.
Anna Lubomski, Henrik Falhammar, David J. Torpy, R. Louise Rushworth   +3 more
doaj   +1 more source

Adrenal Crisis in Children

Cendana Medical Journal (CMJ), 2022
Adrenal Crisis is an acute deterioration of adrenal insufficiency. This condition leads to an emergency condition. The major manifestation of adrenal crisis is hypotension and shock hypovolemic. Unspecified general manifestation would lead to misdiagnosis and suboptimal management of this condition.
openaire   +2 more sources

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Late diagnosis of primary chronic adrenal insufficiency in the framework of autoimmune polyglandular syndrome type 2. Clinical observation

Лечащий Врач, 2023
Chronic adrenal insufficiency is caused by insufficient secretion of hormones by the adrenal cortex due to dysfunction of one or more links of the hypothalamic-pituitary-adrenal system.
V. G. Chobitko, A. P. Belova
doaj   +1 more source

Adrenal Crisis and Autoimmune Polyglandular Syndromes [PDF]

Baylor University Medical Center Proceedings, 2017
We report a 67-year-old woman who presented with adrenal crisis as a manifestation of autoimmune polyglandular syndrome 2, a polygenic disorder characterized by concurrent primary adrenal insufficiency and either autoimmune thyroid disease or type 1 diabetes mellitus.
Zachary K, Freeland, Richard, Lueking, Ginger, Tsai-Nguyen, Thoris, Pan, Adan, Mora   +4 more
openaire   +2 more sources

Adrenal suppression in patients taking inhaled glucocorticoids is highly prevalent and management can be guided by morning cortisol [PDF]

, 2015
Context Up to 3% of US and UK populations are prescribed glucocorticoids (GC). Suppression of the hypothalamo–pituitary–adrenal axis with the potential risk of adrenal crisis is a recognized complication of therapy. The 250 μg short Synacthen stimulation
Argese, N, Arlt, W, Boot, C, Chapman, M, Crowley, RK, Dabhi, V, Grossman, AB, Stewart, PM, Tomlinson, JW, Toogood, AA, Webster, R, Woods, CP   +11 more
core   +2 more sources

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Nivolumab, a new immunomodulatory drug, a new adverse effect; adrenal crisis

Turkish Journal of Emergency Medicine, 2017
Owing to the advancements in medicine, new information is obtained regarding cancer, new antineoplastic agents are developed. Frequent use of these new pharmacological agents emergency physicians to be vigilant about their side effects. We present a case
Funda Karbek Akarca, Ozge Can, Sercan Yalcinli, Yusuf Ali Altunci   +3 more
doaj   +1 more source