Results 121 to 130 of about 37,949 (281)

Adrenal Glands - The Current Stage and New Perspectives of Diseases and Treatment [PDF]

open access: green, 2022
Diana Păun   +28 more
openalex   +1 more source

Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis

open access: yesMed Research, EarlyView.
The review identifies glucocorticoid‐induced osteocyte/osteoblast apoptosis as central to femoral head osteonecrosis (GION), mediated through STAT1‐caspase‐3, PI3K/Akt, Wnt/β‐catenin, and oxidative stress pathways. Emerging therapies targeting these pathways (e.g., HIF‐1α stabilization, AMPK activation, and exosome‐mediated miRNA delivery) show ...
Xiumei Tang   +7 more
wiley   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

open access: yesMed Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin   +8 more
wiley   +1 more source

A Case of Myelolipoma of the Adrenal Gland with Close Examination of other Disease.

open access: bronze, 2001
Akihiro Naito   +4 more
openalex   +2 more sources

Pregnenolone Reduces L‐Dopa‐Induced Dyskinesias in Female Parkinsonian Monkeys

open access: yesMovement Disorders, EarlyView.
Pregnenolone is the first neurosteroid synthesized from cholesterol in the brain. Ovariectomized female monkeys were tested as a model of women in menopause. They were lesioned with MPTP modeling Parkinson's disease and treated with levodopa (L‐dopa) to induce dyskinesias.
Mélanie Bourque   +5 more
wiley   +1 more source

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