Results 141 to 150 of about 477,806 (337)

Glucocorticoid therapy for adrenal insufficiency: nonadherence, concerns and dissatisfaction with information [PDF]

, 2016
Objective: Appropriate self‐management of glucocorticoid therapy (GC) is crucial for patients with adrenal insufficiency (AI). We aimed to describe patients’ self‐reported nonadherence to GC, evaluate perceived doubts about need for GC, concerns about ...
Carroll, P., Chapman, S. C. E, Horne, R., Llahana, S.   +3 more
core   +2 more sources

Current Application Status and Innovative Development of Surgical Robot

Med Research, EarlyView.
Advantage, Challenge and Innovation of surgical robots. ABSTRACT Surgery has undergone a revolutionary development since the innovations in anesthesiology, aseptic techniques, and antibiotics. The use of modern techniques, especially minimally invasive techniques, has led to a new era of microsurgery and reduced patient trauma.
Aimin Jiang, Zhao Tang, Hanzhong Zhang, Jinxin Li, Jialin Meng, Ying Liu, Yu Fang, Juan Lu, Xu Zhang, Le Qu, Anqi Lin, Linhui Wang   +11 more
wiley   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Idiopathic intracranial hypertension as a presenting sign of adrenal insufficiency

SAGE Open Medical Case Reports, 2018
Idiopathic intracranial hypertension is a diagnosis of exclusion defined by elevated intracranial pressure without mass lesions or hydrocephalus.
Sandra Shenouda, Khaled Al-Farawi, Jenna Dolan, Susan L Flesher   +3 more
doaj   +1 more source

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, EarlyView.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source

A Rare Case of Autoimmune Polyglandular Syndrome Type 2 in a Child With Persistent Fatigue

Global Pediatric Health, 2019
Adrenal insufficiency is a rare, potentially life-threatening condition whose diagnosis requires a high index of suspicion. Adrenal insufficiency may be primary, secondary, or tertiary with varied etiologies.
Ryan Kenneth Smith DO, Peter M. Gerrits MD   +1 more
doaj   +1 more source

Once-daily, modified-release hydrocortisone in patients with adrenal insufficiency [PDF]

, 2018
Sirazum Choudhury, Tricia Tan, Karim Meeran   +2 more
openalex   +1 more source

Bioavailability of Magnesium and Potassium Salts Used as Potential Substitutes for Sodium Chloride in Human Nutrition — A Review

Molecular Nutrition &Food Research, EarlyView.
A high intake of sodium chloride contributes to hypertension. This review evaluates the bioavailability of potassium and magnesium salts as sodium chloride alternatives. Potassium chloride and citrate, as well as magnesium citrate and chloride, show good absorption.
Ronja Merschmann, Carlotta Burgmer, Gunter P. Eckert, Anika E. Wagner   +3 more
wiley   +1 more source

Predicting Residual 21‐Hydroxylase Enzymatic Activity in Pediatric and Adult Congenital Adrenal Hyperplasia Patients: Towards Individualized Therapy

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Congenital adrenal hyperplasia (CAH) is a genetic disorder characterized by impaired cortisol production and consequent elevated adrenocorticotropic hormone (ACTH): CAH patients often require lifelong hydrocortisone therapy. Disease severity reflects residual 21‐hydroxylase enzyme activity, crucial for cortisol synthesis.
Davide Bindellini, Robin Michelet, Yersultan Mirasbekov, Qizong Lao, Charles Sukin, Wilhelm Huisinga, Deborah P. Merke, Charlotte Kloft   +7 more
wiley   +1 more source

Population Pharmacokinetic Modeling and Pediatric Exposure of Dexamethasone Sodium Phosphate Encapsulated in Erythrocytes (eDSP) Administered Monthly for Treatment of Neurological Symptoms of Patients With Ataxia Telangiectasia

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The EryDex System (EDS) is a drug/device combination, which has been tested in clinical trials for ataxia telangiectasia (AT). EDS encapsulates dexamethasone sodium phosphate (DSP) solution in autologous erythrocytes at the point of care, and encapsulated DSP (eDSP) is infused back into the patient. Low doses of dexamethasone are released from
Deniz Ozdin, Leila Kheibarshekan, Giovanni Mambrini, Pierre‐Olivier Tremblay   +3 more
wiley   +1 more source