BMC Pregnancy and Childbirth, 2023 Background The upper limit for thyroid-stimulating hormone has been strictly defined for pregnancy management, at which point levothyroxine replacement therapy will been initiated.
Ken Kanazawa +3 more
doaj +1 more source
Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia [PDF]
, 2006 Objective: Familial glucocorticoid deficiency type I (FGD1) is a rare form of primary adrenal insufficiency resulting from recessive mutations in the ACTH receptor (MC2R, MC2R).
Achermann, JC +8 more
core +2 more sources
Adrenal insufficiency development during chemotherapy plus anti-programmed death receptor-1 monoclonal antibody (tislelizumab) therapy in patients with advanced gastric cancer: two case reports [PDF]
Journal of Yeungnam Medical Science, 2022 Immune checkpoint inhibitor (ICI)-associated adrenal insufficiency is rare but may become a serious adverse event in patients treated with ICIs. The present case report documents two cases of adrenal insufficiency developed during chemotherapy plus ...
Jin Ho Baek
doaj +1 more source
Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay [PDF]
, 1999 Although delayed puberty is relatively common and often familial, its molecular and pathophysiologic basis is poorly understood. In contrast, the molecular mechanisms underlying some forms of hypogonadotropic hypogonadism (HH) are clearer, following the ...
Achermann, JC +12 more
core +1 more source
European multicentre study on outcome of surgery for sporadic primary hyperparathyroidism
BJS (British Journal of Surgery), EarlyView., 2020 Some 5861 patients undergoing first‐time surgery for sporadic primary hyperparathyroidism were registered in the Eurocrine® database between 2015 and 2018. The use of intraoperative parathyroid hormone measurement decreased the risk of conversion and persistent hypercalcaemia.
A. Bergenfelz +3 more
wiley +1 more source
Pediatric Adrenal Insufficiency: Diagnosis, Management, and New Therapies
International Journal of Pediatrics, 2018 Adrenal insufficiency may result from a wide variety of congenital or acquired disorders of hypothalamus, pituitary, or adrenal cortex. Destruction or dysfunction of the adrenal cortex is the cause of primary adrenal insufficiency, while secondary ...
Sasigarn A. Bowden, Rohan Henry
doaj +1 more source
Primary adrenal lymphoma: Differential involvement with varying adrenal function
Indian Journal of Endocrinology and Metabolism, 2011 Primary adrenal Non-Hodgkin′s lymphoma is rare. The symptoms of the disease and response to treatment are variable depending on the type of lymphoma, tumor size, and presence of adrenal insufficiency.
Shiekh Aejaz Aziz +4 more
doaj +1 more source
Homozygous disruption of P450 side-chain cleavage (CYP11A1) is associated with prematurity, complete 46,XY sex reversal, and severe adrenal failure [PDF]
, 2005 Disruption of the P450 side-chain cleavage cytochrome (P450scc) enzyme due to deleterious mutations of the CYP11A1 gene is thought to be incompatible with fetal survival because of impaired progesterone production by the fetoplacental unit.
Achermann, JC +8 more
core +1 more source
Frontiers in Neurology, 2015 Prednisolone and adrenocorticotropic hormone (ACTH) are hormone therapies for infantile spasms. There is limited data on the occurrence of decreased adrenal reserve or signs of clinical adrenal insufficiency after hormone therapy. This is a retrospective
John R Mytinger, Sasigarn A Bowden
doaj +1 more source
Trabecular bone score and sclerostin concentrations in patients with primary adrenal insufficiency
Frontiers in Endocrinology, 2022 BackgroundPatients with primary adrenal insufficiency need lifelong replacement therapy with glucocorticoids and mineralocorticoids, which may influence their bone quality.AimThe aim of the study was to evaluate densitometry parameters, trabecular bone ...
Aleksandra Zdrojowy-Wełna +5 more
doaj +1 more source