Vasoreactivity as a Measure of Kidney Viability During Ex Vivo Normothermic Machine Perfusion
Artificial Organs, EarlyView.This study aimed to investigate the influence of warm ischemic injury on renal vascular responsiveness to vasoactive drugs during normothermic machine perfusion (NMP). We found that the vascular responses to dopamine and norepinephrine could be used as objective indicators to assess kidney viability during NMP.
Isa M. van Tricht +4 more
wiley +1 more source
Safety pharmacology of acute mescaline administration in healthy participants
British Journal of Clinical Pharmacology, EarlyView.Aims Psychedelics, including mescaline, may serve as novel treatments for depression and anxiety. However, data is scarce on the safety of mescaline. Methods The present pooled analysis included two double‐blind, randomized, placebo‐controlled studies with a total of 48 participants and 96 mescaline administrations. Single oral‐dose administrations (n =
Aaron Klaiber +4 more
wiley +1 more source
MANAGMENT OF PHENTOLAMINE-RESISTANT PHAEOCHROMOCYTOMA WITH BETA-ADRENERGIC BLOCKADE
, 1969 M. R. SALEM, Anthony D. Ivankovic
openalex +1 more source
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, EarlyView.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source
Relevance of STIM/Orai Calcium Entry System Hyperactivation in Human Prostate Contractility in Benign Prostate Hyperplasia. [PDF]
Int J Mol SciLa Fuente JM +4 more
europepmc +1 more source
PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes
British Journal of Pharmacology, EarlyView.Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier +9 more
wiley +1 more source
Cirrhotic Cardiomyopathy: Bridging Hepatic and Cardiac Pathophysiology in the Modern Era. [PDF]
J Clin MedLupu D +3 more
europepmc +1 more source
Clinical Endocrinology, EarlyView.ABSTRACT Introduction Currently, it is unclear whether plasma free or 24‐h urinary fractionated metanephrines are preferable for diagnosis of phaeochromocytoma/paraganglioma (PPGL) in children. Objectives To investigate whether measurements of plasma free and 24‐h urinary fractionated metanephrines are reliable tests for screening for PPGL in children.
Kristin Potthoff +8 more
wiley +1 more source
Changes and monitoring technology of human heart rate and blood oxygen saturation under high-altitude hypoxia. [PDF]
Front PhysiolLiao Y, Lu D, Yang J.
europepmc +1 more source