Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang +5 more
wiley +1 more source
Berberine ameliorates acute hyperglycemia and hypoinsulinemia induced by ketamine/xylazine in rats: role of alpha<sub>2</sub> adrenergic receptors, oxidative stress and inflammatory suppressing mechanisms. [PDF]
Kadhim RA +4 more
europepmc +1 more source
This study examines the association between the rs1042713 (Arg16Gly) polymorphism of the β2‐adrenergic receptor and the risk of severe eosinophilic asthma, as well as its influence on mepolizumab long‐term effectiveness and clinical remission. The Arg16 allele is associated with increased risk of severe disease and potentially diminished long‐term ...
Santi Nolasco +38 more
wiley +1 more source
Modulation of inflammatory and adrenergic pathways in hypertension: effects of β-blockers on cytokine release in Jurkat T cells. [PDF]
Kajaia N +6 more
europepmc +1 more source
Beta1-Adrenergic Agonist Is a Potent Stimulator of Alveolar Fluid Clearance in Hyperoxic Rat Lungs
Tsutomu Sakuma +8 more
openalex +1 more source
People with spinal cord injury (SCI) experience bladder overactivity, which can cause incontinence. Dorsal genital nerve stimulation (DGNS) can suppress overactivity, providing a longer duration to reach a toilet. People with SCI trialed home‐based DGNS for 8 weeks. DGNS was effective in the laboratory, and participants found home‐based DGNS acceptable.
Sean Doherty +4 more
wiley +1 more source
Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness. [PDF]
Kleyman A +14 more
europepmc +1 more source
Vasoreactivity as a Measure of Kidney Viability During Ex Vivo Normothermic Machine Perfusion
This study aimed to investigate the influence of warm ischemic injury on renal vascular responsiveness to vasoactive drugs during normothermic machine perfusion (NMP). We found that the vascular responses to dopamine and norepinephrine could be used as objective indicators to assess kidney viability during NMP.
Isa M. van Tricht +4 more
wiley +1 more source

