Results 1 to 10 of about 16,552 (150)

The Association Between Alpha-1 Adrenergic Receptor Antagonists and In-Hospital Mortality From COVID-19 [PDF]

Frontiers in Medicine, 2021
Effective therapies for coronavirus disease 2019 (COVID-19) are urgently needed, and pre-clinical data suggest alpha-1 adrenergic receptor antagonists (α1-AR antagonists) may be effective in reducing mortality related to hyperinflammation independent of ...
Liam Rose, Laura Graham, Allison Koenecke, Michael Powell, Ruoxuan Xiong, Zhu Shen, Brett Mench, Kenneth W. Kinzler, Chetan Bettegowda, Chetan Bettegowda, Bert Vogelstein, Susan Athey, Joshua T. Vogelstein, Joshua T. Vogelstein, Maximilian F. Konig, Maximilian F. Konig, Todd H. Wagner, Todd H. Wagner   +17 more
doaj   +5 more sources

Efficacy and safety of adrenergic alpha-1 receptor antagonists in older adults: a systematic review and meta-analysis supporting the development of recommendations to reduce potentially inappropriate prescribing [PDF]

BMC Geriatrics, 2022
Background Adrenergic alpha-1 receptor antagonists (alpha-1 antagonists) are frequently used medications in the management of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) and in the management of therapy-resistant ...
Felix Mansbart, Gerda Kienberger, Andreas Sönnichsen, Eva Mann   +3 more
doaj   +2 more sources

Persistent bothersome urinary frequency following stereotactic body radiation therapy for clinically localized prostate cancer: rationale for prophylactic β3-agonist in men with elevated baseline international prostate symptom scores [PDF]

Frontiers in Oncology
IntroductionStereotactic body radiation therapy (SBRT) for clinically localized prostate cancer has been associated with prolonged acute obstructive and irritative lower urinary tract symptoms (LUTS).
Jennifer Zack, Min Ji Koh, Emily Lindbloom, Timothy O’Connor, Kelly Gaudian, Alan Zwart, Malika Danner, Deepak Kumar, Simeng Suy, Ryan Hankins, Sean Collins   +10 more
doaj   +2 more sources

Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection

eLife, 2021
In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the viral replication phase is often followed by hyperinflammation, which can lead to acute respiratory distress syndrome, multi-organ failure, and death.
Allison Koenecke, Michael Powell, Ruoxuan Xiong, Zhu Shen, Nicole Fischer, Sakibul Huq, Adham M Khalafallah, Marco Trevisan, Pär Sparen, Juan J Carrero, Akihiko Nishimura, Brian Caffo, Elizabeth A Stuart, Renyuan Bai, Verena Staedtke, David L Thomas, Nickolas Papadopoulos, Ken W Kinzler, Bert Vogelstein, Shibin Zhou, Chetan Bettegowda, Maximilian F Konig, Brett D Mensh, Joshua T Vogelstein, Susan Athey   +24 more
doaj   +5 more sources

Do adrenergic alpha‐antagonists increase the risk of poor cardiovascular outcomes? A systematic review and meta‐analysis

ESC Heart Failure, 2022
Due to concerns regarding neurohormonal activation and fluid retention, adrenergic alpha‐1 receptor antagonists (A1Bs) are generally avoided in the setting of heart disease, namely, symptomatic heart failure (HF) with reduced ejection fraction (HFrEF ...
José Pedro Sousa, Diogo Mendonça, Rogério Teixeira, Lino Gonçalves   +3 more
doaj   +2 more sources

Effects of Combination Treatment of Alpha 1-Adrenergic Receptor Antagonists on Voiding Dysfunction: Study on Target Organs in Overactive Bladder Rats [PDF]

International Neurourology Journal, 2016
Purpose Overactive bladder (OAB) causes urinary urgency, usually accompanied by frequency and nocturia. Alpha 1-adrenergic receptor (α1-AR) antagonists are known to improve lower urinary tract symptoms associated with OAB.
Il Gyu Ko, Bo Min Moon, Sung Eun Kim, Jun Jang Jin, Lakkyong Hwang, Eun Sang Ji, Chang Ju Kim, Tai Hyung Kim, Hyun Hee Choi, Kyung Jin Chung   +9 more
doaj   +3 more sources

The use of α1-adrenergic receptor antagonists in the prevention of adverse outcomes of COVID-19 infection in obese patients

Advances in Human Biology, 2022
Obesity is widely reported to be associated with a higher risk of the severity and worse clinical outcome of COVID-19. With the global prevalence of obesity, exploring the relationship between obesity and the severity of COVID-19 disease is of major ...
Auda Fares, Resul Toprak, Dieter Borrman, Julius R Ivester   +3 more
doaj   +1 more source

Predictive value of pupillography on intraoperative floppy iris syndrome in preoperative period [PDF]

International Journal of Ophthalmology, 2021
AIM: To present the frequency of intraoperative floppy iris syndrome (IFIS) in cataract patients who taking alpha 1-a receptor antagonist (ARA) drugs, and evaluate the predictive value of pupil diameter (PD) changes in IFIS patients.
Gozde Sahin Vural, Mehmet Vural
doaj   +1 more source

Otorhinolaryngological adverse effects of urological drugs

International Brazilian Journal of Urology, 2021
Purpose: To describe the otorhinolaryngological adverse effects of the main drugs used in urological practice. Materials and Methods: A review of the scientific literature was performed using a combination of specific descriptors (side effect, adverse ...
Nathalia de Paula Doyle Maia, Karen de Carvalho Lopes, Fernando Freitas Ganança   +2 more
doaj   +1 more source

The Alpha-1 Adrenergic Receptor Antagonist Prazosin Reduces Binge-Like Eating in Rats [PDF]

Nutrients, 2020
Background: Binge-eating disorder is a pervasive addiction-like disorder that is defined by excessive and uncontrollable consumption of food within brief periods of time. The aim of the current study was to examine the role of the brain noradrenergic system in binge-like eating through the use of the alpha-1 adrenergic receptor antagonist prazosin ...
Hicks, Callum, Sabino, Valentina, Cottone, Pietro   +2 more
openaire   +2 more sources