Results 1 to 10 of about 28,463 (245)
Evaluation of low dose prazosin for PTSD-associated nightmares in children and adolescents [PDF]
Mental Health Clinician, 2023 Introduction: Knowledge about fundamental sleep disorders and dysregulation that occurs in children with PTSD is limited. Prazosin is an alpha-1 receptor antagonist often used off label for the treatment of PTSD-associated nightmares in adults; however ...
Nancy Hudson, PharmD +3 more
doaj +4 more sources
Investigation of the Atypical Glass Transition and Recrystallization Behavior of Amorphous Prazosin Salts [PDF]
Pharmaceutics, 2011 This manuscript studied the effect of counterion on the glass transition and recrystallization behavior of amorphous salts of prazosin. Three amorphous salts of prazosin, namely, prazosin hydrochloride, prazosin mesylate and prazosin tosylate were ...
Arvind Bansal +2 more
exaly +4 more sources
Prazosin Displays Anticancer Activity against Human Prostate Cancers: Targeting DNA, Cell Cycle [PDF]
Neoplasia, 2007 Quinazoline-based α1,-adrenoceptor antagonists, in particular doxazosin, terazosin, are suggested to display antineoplastic activity against prostate cancers. However, there are few studies elucidating the effect of prazosin.
Jeff S Chueh +2 more
exaly +4 more sources
Prazosin dosed 3 times a day to treat flashbacks related to PTSD: A case report [PDF]
Mental Health Clinician, 2023 Prazosin is an alpha-1 adrenergic receptor antagonist widely known by mental health providers for its off-label use for nightmares in patients with PTSD.
Christie Richardson, DO, MS +2 more
doaj +6 more sources
The Discovery of α-Adrenoceptor Antagonists as a Potential New Treatment Option for Uveal Melanoma [PDF]
BiomoleculesUveal melanoma (UM) is the most common primary intraocular tumor in adults. Because of its high potential for spreading and its limited response to treatment, UM remains a clinical challenge. Previous studies suggest that clinical adrenergic receptor (AR)
Yilan He +5 more
doaj +2 more sources
International Journal of Electrochemical Science, 2010 Prazosin belongs to the class of alpha-adrenergic blockers, which lower blood pressure by relaxing blood vessels. Based on computiational studies, Prazosin-tetraphenyl borate was selected as a suitable ion-pair reagent in making Prazosin potentiometric ...
Bagher Larijani +2 more
exaly +3 more sources
A sex-sensitive LC-MS/MS method with isotopic internal standard for prazosin bioequivalence: bridging precision medicine and generic drug policy in China [PDF]
Frontiers in PharmacologyObjectiveTo develop a rapid, sensitive, and high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for prazosin quantification in human plasma, validate its application in bioequivalence studies, and investigate sex-specific ...
Hui Chen +6 more
doaj +2 more sources
Prazosin for the management of behavioural and psychological symptoms of dementia
Drugs in Context, 2022 Prazosin, a centrally acting α1 adrenoceptor antagonist, has been included in two published algorithms amongst the list of medications that may be used in the management of behavioural and psychological symptoms of dementia (BPSD).
Rajesh R Tampi +4 more
doaj +1 more source
Frontiers in Psychiatry, 2022 Psychological trauma in childhood can lead to post-traumatic disorder (PTSD) with protracted comorbid depression, which responds poorly to conventional antidepressants.
Ping Guo +7 more
doaj +1 more source
Chronic Stress, 2021 Background The α 1 -adrenoreceptor antagonist prazosin has in many but not all studies been found to be effective for PTSD associated nightmares, hyperarousal symptoms, and total symptom severity.
Rebecca C. Hendrickson +4 more
doaj +1 more source