Results 21 to 30 of about 28,463 (245)

A Feasibility Study of the Repurposing of Prazosin to Improve Treatment Outcomes in Men Receiving Radiotherapy for Prostate Cancer (MiniRaP-00). [PDF]

Prostate
ABSTRACT Background Further work is needed to improve treatment outcomes for prostate cancer (PCa), with the repurposing of the α1‐adrenoreceptor antagonists presenting a potential solution. This feasibility clinical trial presents the first prospective data of the use of an α1‐adrenoreceptor antagonist in men undergoing radiotherapy for PCa.
King LD, Christie D, Cehic D, Dare W, Chess-Williams R, Sellers D, McDermott C, McCarthy A, Anoopkumar-Dukie S.   +8 more
europepmc   +2 more sources

Prazosin administration increases the rate of recurrent urethral obstruction in cats: 388 cases.

Journal of the American Veterinary Medical Association, 2022
OBJECTIVE To determine if prazosin administration decreased the rate of recurrent urethral obstruction (rUO) before hospital discharge and within 14 days. ANIMALS 388 cats with urethral obstruction. PROCEDURES Veterinarians who either always or never
David S Conway, E. Rozanski, A. Wayne
semanticscholar   +1 more source

ALCOHOL WITHDRAWAL SYMPTOMS PREDICT CORTICOSTRIATAL DYSFUNCTION THAT IS REVERSED BY PRAZOSIN TREATMENT IN ALCOHOL USE DISORDER

Addiction Biology, 2021
Chronic alcohol use increases risk of alcohol withdrawal symptoms (AW) and disrupts stress biology and resilient coping, thereby promoting excessive alcohol intake.
R. Sinha, Nia Fogelman, S. Wemm, G. Angarita, D. Seo, Gretchen Hermes   +5 more
semanticscholar   +1 more source

Using Prazosin to Treat Posttraumatic Stress Disorder and Associations: A Systematic Review

Psychiatry Investigation, 2021
Objective A central adrenergic hyperactivation is described in the neurobiology of posttraumatic stress disorder (PTSD) with probable variable symptomatic impact.
H. Paiva, I. Filho, Carlos F. S. Cais
semanticscholar   +1 more source

Renoprotective effects of prazosin on ischemia-reperfusion injury in rats

Human and Experimental Toxicology, 2021
Background: Renal ischemia-reperfusion (IR) injury is one of the main leading causes of acute kidney injury associated with inflammation, oxidative stress and cell apoptosis. We studied the effects of prazosin, as a specific blocker of α1-AR, on renal IR
M. Rahimi, A. Bagheri, Y. Bagheri, E. Fathi, S. Bagheri, A. Nia, S. Jafari, S. Montazersaheb   +7 more
semanticscholar   +1 more source

Influence of prazosin on systemic iron levels and the associated iron metabolic alterations in spontaneously hypertensive rats

Pharmacology Research & Perspectives, 2022
The relationship between cardiovascular diseases and iron disorders has gained increasing attention; however, the effects of hypotensive drugs on iron metabolic alterations in hypertension are not well understood.
Hengrui Chang, Dong Zhang, Zhen Xin, Pengfei Zhang, Wenyuan Ding, Yan‐Zhong Chang   +5 more
doaj   +1 more source

Effects of chronic prazosin, an alpha-1 adrenergic antagonist, on anxiety-like behavior and cortisol levels in a chronic unpredictable stress model in zebrafish (Danio rerio) [PDF]

PeerJ, 2020
Post-traumatic stress disorder (PTSD) is often associated with significant neuroendocrine dysfunction and a variety of other symptoms. Today, there are limited efficacious treatment options for PTSD, none of which directly target the dysfunction observed
Michael P. O’Daniel, Maureen L. Petrunich-Rutherford   +1 more
doaj   +2 more sources

Prazosin during threat discrimination boosts memory of the safe stimulus [PDF]

, 2017
The α-1 adrenoreceptor antagonist prazosin has shown promise in the treatment of post-traumatic stress disorder (PTSD) symptoms, but its mechanisms are not well understood. Here we administered prazosin or placebo prior to threat conditioning (day 1) and
Lin, Qi, Soleimani, Laili, Clem, Roger L, Homan, Philipp; https://orcid.org/, Schiller, Daniela; https://orcid.org/, Murrough, James W, Bach, Dominik R; https://orcid.org/   +6 more
core   +6 more sources

The efficacy of administration of prazosin in reducing the risk of recurrent urethral obstruction in male cats

Veterinary Evidence, 2023
PICO Question In male cats presenting with urethral obstruction, does administration of prazosin compared with no administration of prazosin reduce the incidence of recurrent urethral obstruction within the first month of initial presentation ...
Rebecca Hearne
doaj   +1 more source

Moderation of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms

American Journal of Psychiatry, 2020
Objective: Alcohol use disorder (AUD) is a leading cause of global disease burden. Chronic, heavy use increases the likelihood of alcohol withdrawal symptoms and associated secondary outcomes of alcohol craving and mood, anxiety, and sleep disturbances ...
R. Sinha, S. Wemm, Nia Fogelman, Verica Milivojevic, Peter M. Morgan, G. Angarita, Gretchen Hermes, H. Fox   +7 more
semanticscholar   +1 more source