6-Nitrodopamine Potentiates Catecholamine-Induced Ca<sup>2+</sup> <sub>i</sub> Release in Human Aortic Smooth Muscle and Modulates Vascular Smooth Muscle Contractility. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Background In vascular smooth muscle, rises in intracellular calcium [Ca2+]i drive contraction downstream of α1‐adrenoceptor activation via IP3. Endothelium‐derived 6‐nitrodopamine (6‐ND) augments cardiac catecholamine actions; however, its effect on [Ca2+]i is unknown.
Britto-Júnior J +7 more
europepmc +2 more sources
Effects of chronic prazosin, an alpha-1 adrenergic antagonist, on anxiety-like behavior and cortisol levels in a chronic unpredictable stress model in zebrafish (Danio rerio) [PDF]
PeerJ, 2020 Post-traumatic stress disorder (PTSD) is often associated with significant neuroendocrine dysfunction and a variety of other symptoms. Today, there are limited efficacious treatment options for PTSD, none of which directly target the dysfunction observed
Michael P. O’Daniel +1 more
doaj +2 more sources
Veterinary Evidence, 2023 PICO Question In male cats presenting with urethral obstruction, does administration of prazosin compared with no administration of prazosin reduce the incidence of recurrent urethral obstruction within the first month of initial presentation ...
Rebecca Hearne
doaj +1 more source
Antibiotics, 2022 Salmonella enterica is a Gram-negative orofecal transmitted pathogen that causes a wide diversity of local and systemic illnesses. Salmonella enterica utilizes several interplayed systems to regulate its invasion and pathogenesis: namely, quorum sensing (
Mahmoud A. Elfaky +7 more
doaj +1 more source
Pharmaceutics, 2011 This manuscript studied the effect of counterion on the glass transition and recrystallization behavior of amorphous salts of prazosin. Three amorphous salts of prazosin, namely, prazosin hydrochloride, prazosin mesylate and prazosin tosylate were ...
Arvind K. Bansal +2 more
doaj +1 more source
Tissue compatibility of poly(hydroxypropylglutamate)-prazosin conjugates [PDF]
, 1992 Biocompatibility of an injectable biodegradable drug delivery system for prazosin was investigated in Sprague-Dawley rats by histological studies after subcutaneous injection ofpoly(hydroxypropyl glutamate)-prazosin (PHPG-prazosin) conjugate particles ...
Anderson, James M. +4 more
core +2 more sources
Case series: Continued remission of PTSD symptoms after discontinuation of prazosin
Frontiers in Psychiatry, 2023 Post-traumatic stress disorder is a debilitating chronic illness that affects 6 out of 100 adults after a severe trauma. The alpha-adrenergic antagonist prazosin, which is prescribed off-label for flashbacks and nightmares due to trauma, is often ...
Christie Richardson +3 more
doaj +1 more source
Single prazosin infusion in prelimbic cortex Fosters extinction of amphetamine-induced conditioned place preference [PDF]
, 2017 Exposure to drug-associated cues to induce extinction is a useful strategy to contrast cue-induced drug seeking. Norepinephrine (NE) transmission in medial prefrontal cortex has a role in the acquisition and extinction of conditioned place preference ...
Alessandro Rava +8 more
core +4 more sources
Prazosin Displays Anticancer Activity against Human Prostate Cancers: Targeting DNA, Cell Cycle
Neoplasia: An International Journal for Oncology Research, 2007 Quinazoline-based α1,-adrenoceptor antagonists, in particular doxazosin, terazosin, are suggested to display antineoplastic activity against prostate cancers. However, there are few studies elucidating the effect of prazosin.
Ssu-Chia Lin +7 more
doaj +1 more source
Prazosin Can Prevent Glucocorticoid Mediated Capillary Rarefaction. [PDF]
PLoS ONE, 2016 Glucocorticoids (GC) elicit skeletal muscle capillary rarefaction, which can subsequently impair blood distribution and muscle function; however, the mechanisms have not been established.
Erin R Mandel +6 more
doaj +1 more source