Biology, 2022 Quorum sensing (QS) controls the production of several bacterial virulence factors. There is accumulative evidence to support that targeting QS can ensure a significant diminishing of bacterial virulence.
Abrar K. Thabit +7 more
doaj +2 more sources
Antibiotics, 2022 Salmonella enterica is a Gram-negative orofecal transmitted pathogen that causes a wide diversity of local and systemic illnesses. Salmonella enterica utilizes several interplayed systems to regulate its invasion and pathogenesis: namely, quorum sensing (
Mahmoud A. Elfaky +7 more
doaj +2 more sources
The Neurochemical Effects of Prazosin Treatment on Fear Circuitry in a Rat Traumatic Stress Model [PDF]
Clinical Psychopharmacology and Neuroscience, 2020 Objective The timing of administration of pharmacologic agents is crucial in traumatic stress since they can either potentiate the original fear memory or may cause fear extinction depending on the phase of fear conditioning.
Sema Ketenci +5 more
semanticscholar +2 more sources
Prazosin Can Prevent Glucocorticoid Mediated Capillary Rarefaction. [PDF]
PLoS ONE, 2016 Glucocorticoids (GC) elicit skeletal muscle capillary rarefaction, which can subsequently impair blood distribution and muscle function; however, the mechanisms have not been established.
Erin R Mandel +6 more
doaj +3 more sources
Efficacy of scorpion antivenom plus prazosin compared with prazosin alone for scorpion sting in children: A cross sectional study [PDF]
Al Ameen Journal of Medical SciencesBackground: Scorpion sting can pose as a life threatening acute medical emergency, which, if not attended to on an emergency basis can result in mortality. Scorpion venoms are a composed of a complex mixture of proteins.
R. Nagarjun, Pooja G. Manoli, A. Ashoka
doaj +2 more sources
EMBO Molecular Medicine, 2016 A variety of drugs targeting monoamine receptors are routinely used in human pharmacology. We assessed the effect of these drugs on the viability of tumor‐initiating cells isolated from patients with glioblastoma.
Suzana Assad Kahn +18 more
doaj +2 more sources
Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease. [PDF]
Neurobiology of Aging, 2013 Noradrenergic deficits have been described in the hippocampus and the frontal cortex of Alzheimer's disease brains, which are secondary to locus coeruleus degeneration.
Loukia Katsouri +8 more
semanticscholar +2 more sources
Prazosin Prevents Increased Anxiety Behavior That Occurs in Response to Stress During Alcohol Deprivations [PDF]
Alcohol and Alcoholism, 2017 AIMS: Stress-induced anxiety is a risk factor for relapse to alcohol drinking. The aim of this study was to test the hypothesis that the central nervous system (CNS)-active α1-adrenergic receptor antagonist, prazosin, would block the stress-induced ...
D. Rasmussen, C. Kincaid, J. Froehlich
semanticscholar +2 more sources
Effect of tamsulosin versus prazosin on clinical and urodynamic parameters in women with voiding difficulty: a randomized clinical trial [PDF]
International Journal of General Medicine, 2011 Sakineh Hajebrahimi1, Yadollah Ahmadi Asrbadr1, Arash Azaripour1, Homayoun Sadeghi-Bazargani2,31Urology Department, Imam Reza University Hospital, Tabriz, Iran; 2Neuroscience Research Center and RDCC, Tabriz University of Medical Sciences, Tabriz, Iran ...
Sakineh Hajebrahimi +3 more
doaj +2 more sources
THE EFFECT OF PRAZOSIN ON COMBAT RELATED POSTTRAUMATIC STRESS DISORDER NIGHTMARES [PDF]
Journal of Research in Medical Sciences, 2003 Introduction: Several studies have shown noradrenergic system hyperactivity in posttraumatic stress disorder. Four Vietnam combat veterans with chronic PTSD, prescribed prazosin ?1 adrenergic receptor antagonist reported reduction or completely ...
G ASSADOUAHI +4 more
doaj +1 more source