Results 111 to 120 of about 16,552 (150)
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α1-Adrenergic Receptor Subtype Determinants for 4-Piperidyl Oxazole Antagonists
Biochemistry, 1998Mutational studies in conjunction with ligand binding assays were used to examine the basis of alpha1-adrenergic receptor subtype selectivity for a series of 4-piperidyloxazole antagonists. A set of chimeric alpha 1A receptors were created by systematically substituting individual transmembrane domains from alpha 1D adrenergic receptors.
N, Hamaguchi +5 more
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α1-Adrenergic Receptor Antagonists and the Iris: New Mechanistic Insights into Floppy Iris Syndrome
Survey of Ophthalmology, 2006Understanding the role of adrenergic receptors in iris biology has gained widespread interest due to the recently described intraoperative floppy iris syndrome sometimes encountered during cataract surgery. alpha(1)AR-mediated iris dilator smooth muscle contraction occurs via alpha(1a)ARs whereas alpha(1b)ARs mediate iris arteriolar contraction ...
Debra A, Schwinn, Natalie A, Afshari
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Molecular Pharmacology, 1983
Alpha 1-Adrenergic receptors of a nonfusing muscle cell line (BC3H1) have been identified on intact and broken-cell preparations by using the high-affinity antagonist [3H]prazosin. In intact cells, both equilibrium and kinetic studies gave KD values in the range of 0.07-0.12 nM.
F, Sladeczek, J, Bockaert, J P, Mauger
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Alpha 1-Adrenergic receptors of a nonfusing muscle cell line (BC3H1) have been identified on intact and broken-cell preparations by using the high-affinity antagonist [3H]prazosin. In intact cells, both equilibrium and kinetic studies gave KD values in the range of 0.07-0.12 nM.
F, Sladeczek, J, Bockaert, J P, Mauger
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The effect of various alpha1-adrenergic receptor antagonists on pupillary dilation.
Annals of ophthalmology (Skokie, Ill.), 2008We prospectively evaluated the effect of various systemic alpha1 adrenergic receptor antagonists on pupillary dilation in patients with benign prostatic hyperplasia. Patients who are at risk for intraoperative floppy iris syndrome cannot be elucidated simply by judging preoperative dilation.
SAATCİ, ALİ OSMAN +6 more
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The Journal of Pharmacology and Experimental Therapeutics, 1987
Evidence for a nonlinear relationship between alpha-1 adrenergic receptor occupancy and tissue responses, together with the finding of different affinity states for agonist binding, has raised the possibility of functional heterogeneity of alpha-1 adrenergic receptors. We have conducted studies to examine: 1) binding characteristics of [3H]prazosin, 2)
G, Jagadeesh, R C, Deth
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Evidence for a nonlinear relationship between alpha-1 adrenergic receptor occupancy and tissue responses, together with the finding of different affinity states for agonist binding, has raised the possibility of functional heterogeneity of alpha-1 adrenergic receptors. We have conducted studies to examine: 1) binding characteristics of [3H]prazosin, 2)
G, Jagadeesh, R C, Deth
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Molecular Pharmacology, 1996
alpha 1-Adrenergic receptor (AR) subtypes mediate many effects of the sympathetic nervous system. Although structurally similar, the three cloned subtypes (alpha 1a-AR, alpha 1b-AR, and alpha 1d-AR) bind a series of ligands with different relative potencies. This is particularly true for the alpha 1a-AR, which recognizes a number of ligands with 10-100-
M M, Zhao, J, Hwa, D M, Perez
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alpha 1-Adrenergic receptor (AR) subtypes mediate many effects of the sympathetic nervous system. Although structurally similar, the three cloned subtypes (alpha 1a-AR, alpha 1b-AR, and alpha 1d-AR) bind a series of ligands with different relative potencies. This is particularly true for the alpha 1a-AR, which recognizes a number of ligands with 10-100-
M M, Zhao, J, Hwa, D M, Perez
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Effect of α1-Adrenergic Receptor Antagonists on Susceptibility to Malignant Arrhythmias
Journal of Cardiovascular Pharmacology, 1994alpha-Adrenergic receptor responsiveness has been reported to increase during myocardial ischemia, correlating with onset of malignant arrhythmias. If alpha-adrenoceptor mechanisms play a significant role in induction of life-threatening arrhythmias, inhibition of these receptors with specific alpha-adrenoceptor antagonists should protect against ...
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Toxicology and Applied Pharmacology, 1999
Bolus intravenous injections of phosphorothioate oligonucleotides (PS-ODN) into primates cause profound hypotension, which has been attributed to complement activation, the biochemical pathway leading to acute inflammatory response. Because the hypotension was not accompanied by peripheral or pulmonary edema and epinephrine was not effective, but ...
P L, Iversen +4 more
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Bolus intravenous injections of phosphorothioate oligonucleotides (PS-ODN) into primates cause profound hypotension, which has been attributed to complement activation, the biochemical pathway leading to acute inflammatory response. Because the hypotension was not accompanied by peripheral or pulmonary edema and epinephrine was not effective, but ...
P L, Iversen +4 more
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Journal of Ocular Pharmacology and Therapeutics, 2013
To evaluate structural alterations of iris and pupil diameters (PDs) in patients using systemic α-1-adrenergic receptor antagonists (α-1ARAs), which are associated with intraoperative floppy iris syndrome (IFIS).Eighty-eight eyes of 49 male were evaluated prospectively. Patients were assigned to 2 different groups.
ALAN, CABİR +5 more
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To evaluate structural alterations of iris and pupil diameters (PDs) in patients using systemic α-1-adrenergic receptor antagonists (α-1ARAs), which are associated with intraoperative floppy iris syndrome (IFIS).Eighty-eight eyes of 49 male were evaluated prospectively. Patients were assigned to 2 different groups.
ALAN, CABİR +5 more
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Comments To: Anterior Segment Morphologic Changes Related to α-1 Adrenergic Receptor Antagonists Use
European Journal of Ophthalmology, 2016[No abstract available]
Palamar M., Emre S., Turna B., Yagci A.
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