Results 121 to 130 of about 16,552 (150)

Computer Modeling of Size and Shape Descriptors of α1-Adrenergic Receptor Antagonists and Quantitative Structure–Affinity/Selectivity Relationships

Methods, 1998
Computational chemistry and molecular modeling procedures allow us to define and compute ad hoc size and shape descriptors on the different prototropic forms assumed by drugs in biotest solutions. Together with experimental data measured on a well-identified target receptor, these descriptors are essential elements for obtaining simple, consistent ...
MONTORSI, Monia, MENZIANI, Maria Cristina, COCCHI, Marina, FANELLI, Francesca, DE BENEDETTI, Pier Giuseppe   +4 more
openaire   +2 more sources

Modeling of alpha(1) adrenergic receptors: the application in the design of selective alpha(1B)-adrenergic antagonists

2005
19th American Peptide Symposium, San Diego, Jun 18-23 ...
Erić, Slavica, Solmajer, Tom, Oblak, M, Kotnik, Miha, Agbaba, Danica   +4 more
openaire   +2 more sources

Interaction of subtype-selective antagonists with alpha 1-adrenergic receptor binding sites in rat tissues.

Molecular pharmacology, 1991
(+)-Niguldipine inhibited specific 125I-BE 2254 binding more potently in membrane preparations from rat tissues enriched in the alpha 1A subtype (hippocampus and vas deferens) than those with the alpha 1B subtype (liver and spleen). Inhibition curves for (+)-niguldipine were better fit by a two-site model in most tissues, although Kl values for each ...
C D, Han, K P, Minneman
openaire   +1 more source

Studies on calcium antagonistic and alpha 1-adrenergic receptor blocking activities of monatepil maleate, its metabolites and their enantiomers.

Arzneimittel-Forschung, 1996
The calcium antagonistic and alpha 1-adrenergic receptor blocking activities of monatepil maleate (CAS 103377-41-9, (+/-)-N-(6,11-dihydrodibenzo [b, e] thiepin-11-yl) -4-(4-fluorophenyl)-1-piperazinebutanamide monomaleate, AJ-2615), a novel calcium antagonist, its metabolites and their enantiomers were studied in vitro.
Y, Honda, Y, Masuda, T, Yoshida, F, Sato, M, Kurokawa, K, Hosoki   +5 more
openaire   +1 more source

Iris morphologic changes related to alpha(1)-adrenergic receptor antagonists implications for intraoperative floppy iris syndrome.

Ophthalmology, 2009
To identify iris structural alterations associated with intraoperative floppy iris syndrome (IFIS) in patients using systemic alpha(1)-adrenergic receptor antagonists (alpha-1ARA).Cross-sectional study.Twenty-nine patients with current or past treatment with any systemic alpha-1ARA and 22 untreated controls.Consecutive eligible patients underwent slit ...
Tiago Santos, Prata, Pat-Michael, Palmiero, Allison, Angelilli, Zaher, Sbeity, Carlos Gustavo V, De Moraes, Jeffrey M, Liebmann, Robert, Ritch   +6 more
openaire   +1 more source

Pseudoallergic conjunctivitis induced by tamsulosin, a selective alpha-1 adrenergic receptor antagonist

The Journal of Allergy and Clinical Immunology: In Practice, 2018
Brian T. Kelly, Bradley A. Locke, Kevin J. Kelly   +2 more
openaire   +1 more source

Meta-analysis of the efficacy and adverse drug reactions of adrenergic alpha-antagonists in treating children with ureteral calculi

Frontiers in Pediatrics, 2023
Wang Qingliang, Zhang Peizhi, Xia Qinghua   +2 more
exaly  

Risk of Severe COVID-19 in Prevalent Users of Alpha-1 Adrenergic Receptor Antagonists: A National Case-Control Study of Medicare Beneficiaries

American Journal of Medicine, 2023
Jeffrey A Kelman
exaly  

Alpha-adrenergic antagonists: Correlation of the effect on intraocular pressure and on α2-adrenergic receptor binding specificity in the rabbit eye

Experimental Eye Research, 1985
Thomas W Mittag, Steven M Podos, T W Mittag   +2 more
exaly  

Effects of intrathecal injection of tamsulosin and naftopidil, alpha-1A and -1D adrenergic receptor antagonists, on bladder activity in rats

Neuroscience Letters, 2002
Saori Nishijima, Kimio Sugaya, Minoru Miyazato   +2 more
exaly