Experimental Physiology, EarlyView.Abstract Improving adipose tissue (AT) metabolism through exercise might increase production of lipokines from the fatty acid esters of hydroxy fatty acids (FAHFA) family. Although exercise training can increase insulin sensitivity and levels of specific FAHFA in AT and the circulation in humans, the effects of acute exercise on FAHFA levels remain ...
Marko Mitrovic +7 more
wiley +1 more source
Identification of novel peripherally restricted risperidone-like dopamine D2 receptor antagonists for prolactin-mediated neuroprotection through a multi-stage in silico screening. [PDF]
PLoS OneKim S, Jo WH, Cha JO, Kim MS.
europepmc +1 more source
The acute and chronic effects of local aerobic exercise on cardiovascular physiology
Experimental Physiology, EarlyView.Abstract Exercise training has beneficial effects for primary and secondary prevention of cardiovascular disease (CVD). Effects of exercise training have typically been studied in the form of whole‐body exercise training, partly driven by the assumption that larger effects of exercise training can be achieved by involving more and larger muscle groups.
Myrthe P. F. van de Ven +3 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract We tested the hypothesis that two different durations of lower leg transcutaneous electrical nerve stimulation (TENS) increase post‐TENS popliteal artery blood flow (PABF), popliteal vascular conductance (PVC), and 6‐min walk distance (6MWD) in patients with peripheral artery disease (PAD).
Thomas K. Pellinger +7 more
wiley +1 more source
Adrenergic receptors: a key determinant of outcomes in bacterial pneumonia and bacterial sepsis-associated acute lung injury/acute respiratory distress syndrome through participation in pulmonary innate immune response. [PDF]
Front ImmunolZeng L, Yang J, Yan J.
europepmc +1 more source
Experimental Physiology, EarlyView.Abstract Circulatory shock remains difficult to manage because fluid resuscitation and catecholamines may exacerbate vascular dysfunction and tissue hypoperfusion. This prospective physiological analysis, embedded within a multicentre phase IV study, examined whether selectively targeting the venous circulation with centhaquine improves circulatory ...
Athanasios Chalkias +4 more
wiley +1 more source
Genomic Evidence on Antihypertensive Drug Targets and Oral Disease Outcomes. [PDF]
J Periodontal ResPuzhakkara Chennas A +7 more
europepmc +1 more source
Experimental Physiology, EarlyView.Abstract Cold‐water immersion (CWI) is among the most widely used post‐exercise recovery modalities in elite sport and clinical rehabilitation, yet a fundamental paradox now emerges from the evidence: the same protocols that accelerate parasympathetic reactivation and reduce perceived muscle soreness also suppress the molecular and cellular machinery ...
Jose Francisco Tornero‐Aguilera +8 more
wiley +1 more source
Intra-Accumbal Infusions of an α<sub>2</sub>-Adrenoceptor Agonist and an α<sub>2</sub>-Adrenoceptor Antagonist Respectively Inhibit and Enhance Acetylcholine but Not Dopamine Efflux in the Nucleus Accumbens of Freely Moving Rats. [PDF]
SynapseArai K +5 more
europepmc +1 more source
TMEM16A channel signalling microdomains in the regulation of vascular function
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley +1 more source