Results 71 to 80 of about 989,789 (251)

Safety of Alpha-Adrenergic Receptor Antagonists in Heart Failure

, 2018
OBJECTIVES: This study evaluated whether alpha-blocker (AB) use following an admission for heart failure (HF) was associated with an increased risk of HF readmission or death.
Jackevicius, Cynthia A, Warner, Alberta L, Ghaznavi, Zunera, Lu, Lingyun   +3 more
core   +1 more source

Paediatric clonidine medication errors: Findings from a multicentre French study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to describe the characteristics of medication errors involving clonidine in paediatric patients and reported to French Network of Pharmacovigilance and Poison Control Centres. Methods This retrospective observational study analysed clonidine‐related medication errors reported between 1985 and June 2024 in patients under 12 years ...
Eve‐Marie Thillard, Anthony Facile, Marion Lepelley, Morgane Cellier, Laurent Chouchana, Sophie Gautier, Ramy Azzouz, Thierry Vial, Annie‐Pierre Jonville‐Bera   +8 more
wiley   +1 more source

Alpha-adrenergic regulation of secretion by tracheal glands

, 1990
The purpose of the present study was to begin to characterize, pharmacologically, the alpha-adrenergic regulation of glycoconjugate secretion from airway glands.
M. G. Marin, R. K. McBride, D. J. Culp, L. A. Graham   +3 more
core   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Differences in myocardial alpha- and beta-adrenergic receptor numbers in different species

, 1983
In the present study, we tested the hypotheses that 1) different species have different myocardial adrenergic receptor numbers and 2) selected “slow-channel” calcium antagonists compete with alpha-adrenergic antagonists for binding to varying degrees in
Z. Haghani, A. Mukherjee, J. Brady, W. McBride, L. M. Buja, L. Bush, J. T. Willerson   +6 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Cardiomyocyte Alpha-1A Adrenergic Receptors Mitigate Postinfarct Remodeling and Mortality by Constraining Necroptosis

JACC: Basic to Translational Science
Summary: Clinical studies have shown that α1-adrenergic receptor antagonists (α-blockers) are associated with increased heart failure risk. The mechanism underlying that hazard and whether it arises from direct inhibition of cardiomyocyte α1-ARs or from ...
Jiandong Zhang, MD, PhD, Peyton B. Sandroni, BS, Wei Huang, MS, Xiaohua Gao, PhD, Leah Oswalt, PhD, Melissa A. Schroder, BS, SungHo Lee, DVM, PhD, Yen-Yu I. Shih, PhD, Hsiao-Ying S. Huang, PhD, Philip M. Swigart, MS, Bat E. Myagmar, MD, PhD, Paul C. Simpson, MD, Joseph S. Rossi, MD, Jonathan C. Schisler, PhD, Brian C. Jensen, MD   +14 more
doaj   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

The use and rationale of selective alpha blockade in children with non-neurogenic neurogenic bladder dysfunction

International Brazilian Journal of Urology, 2004
INTRODUCTION: We present here a long-term observation of 2 children with a rare syndrome with a non-neurogenic neurogenic bladder dysfunction (Hinman's syndrome), and we investigated the safety and efficacy of long-term use of terazosine in association ...
Guy Bogaert, Goedele Beckers, Rita Lombaerts   +2 more
doaj   +1 more source

Inflammation contributes to axon reflex vasodilatation evoked by iontophoresis of an alpha-1 adrenoceptor agonist [PDF]

, 2011
Iontophoresis of aradrenoceptor agonists in the human forearm evoke axon reflex vasodilatation, possibly due to an accumulation of inflammatory agents at the site of iontophoresis.
Drummond, P.D.
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