Results 1 to 10 of about 42,003 (148)

Persistent bothersome urinary frequency following stereotactic body radiation therapy for clinically localized prostate cancer: rationale for prophylactic β3-agonist in men with elevated baseline international prostate symptom scores [PDF]

Frontiers in Oncology
IntroductionStereotactic body radiation therapy (SBRT) for clinically localized prostate cancer has been associated with prolonged acute obstructive and irritative lower urinary tract symptoms (LUTS).
Jennifer Zack, Min Ji Koh, Emily Lindbloom, Timothy O’Connor, Kelly Gaudian, Alan Zwart, Malika Danner, Deepak Kumar, Simeng Suy, Ryan Hankins, Sean Collins   +10 more
doaj   +2 more sources

Human fat cell beta-adrenergic receptors: beta-agonist-dependent lipolytic responses and characterization of beta-adrenergic binding sites on human fat cell membranes with highly selective beta 1-antagonists.

Journal of Lipid Research, 1988
Beta-adrenergic receptors were characterized in human fat cell membranes using 125I-labeled cyanopindolol (125I-labeled CYP) and highly selective beta 1-antagonists.
P Mauriège, G De Pergola, M Berlan, M Lafontan   +3 more
doaj   +3 more sources

Evaluation of the effects of Astragalus fasciculifolius hydroalcoholic extract on rat ileum contractions: The role of adrenergic, opioid, and nitric oxide receptors [PDF]

Future Natural Products, 2023
Background and aims: This study aimed to determine the effects of Astragalus fasciculifolius hydroalcoholic extract on rat ileum contractions: The role of adrenergic, opioid, and nitric oxide (NO) receptors. Methods: A.
Najmeh Asgharzadeh, Parisa Zamani, Fatemeh Azizi, Hossein Amini-Khoei, Elham Bijad, Mehrdad Shahrani-Korani   +5 more
doaj   +1 more source

The Anti-Inflammatory Effect of the β1-Adrenergic Receptor Antagonist Metoprolol on High Glucose Treated Human Microvascular Retinal Endothelial Cells [PDF]

Cells, 2021
Hyperglycemia-induced impairment of the blood-retinal barrier represents the main pathological event in diabetic retinopathy that is elicited by a reduced cellular response to an accumulation of reactive oxygen species (ROS) and increased inflammation.
Giovanni Giurdanella, Anna Longo, Alfio Distefano, Melania Olivieri, Martina Cristaldi, Alessia Cosentino, Aleksandra Agafonova, Nunzia Caporarello, Gabriella Lupo, Carmelina Daniela Anfuso   +9 more
openaire   +3 more sources

Identifying Ligand Binding Conformations of the β2-Adrenergic Receptor by Using Its Agonists as Computational Probes [PDF]

, 2011
Recently available G-protein coupled receptor (GPCR) structures and biophysical studies suggest that the difference between the effects of various agonists and antagonists cannot be explained by single structures alone, but rather that the conformational
Ashley M. Buckle, B Isin, B Isin, B Isin, Basak Isin, BK Kobilka, BK Kobilka, C Gales, CD Strader, CD Strader, CD Strader, DL Farrens, DM Rosenbaum, DM Rosenbaum, DS Han, E Reiter, FZ Chung, G Liapakis, G Liapakis, G Swaminath, G Swaminath, Guillermina Estiu, GV Paolini, HW Choe, I Bahar, JA Javitch, JC Phillips, JE Olsson, JJ Liu, JP Overington, K Palczewski, K Wieland, KA Reynolds, L Shi, LM Luttrell, LS Barak, M Arakawa, M Azzi, MA Yildirim, MP Bokoch, MS Johnson, O Fritze, Olaf Wiest, P Ghanouni, PG Strange, R Nygaard, R Seifert, RA Friesner, RA Friesner, RO Dror, S Ahuja, S Bhattacharya, S Ludeke, SA Green, SG Rasmussen, SG Rasmussen, SG Rasmussen, T Palanche, TD Romo, U Gether, V Cherezov, X Deupi, X Yao, X Zhang, Zoltán N. Oltvai   +64 more
core   +10 more sources

The Potential Anti-remodeling Effect of Paroxetine After Myocardial Infarction May Be Blunted by Beta-Blockers

Frontiers in Cardiovascular Medicine, 2022
BackgroundLeft ventricular (LV) remodeling consists in maladaptive changes in cardiac geometry and function following an insult such as ST-segment elevation myocardial infarction (STEMI).
Oriol Iborra-Egea, Oriol Iborra-Egea, Alberto Aimo, Alberto Aimo, Nicola Martini, Carolina Galvez-Monton, Carolina Galvez-Monton, Silvia Burchielli, Giorgia Panichella, Claudio Passino, Claudio Passino, Michele Emdin, Michele Emdin, Antoni Bayes-Genis, Antoni Bayes-Genis, Antoni Bayes-Genis   +15 more
doaj   +1 more source

Betaxolol, a selective β1-adrenergic receptor antagonist, diminishes anxiety-like behavior during early withdrawal from chronic cocaine administration in rats [PDF]

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2007
Anxiety has been indicated as one of the main symptoms of the cocaine withdrawal syndrome in human addicts and severe anxiety during withdrawal may potentially contribute to relapse. As alterations in noradrenergic transmission in limbic areas underlie withdrawal symptomatology for many drugs of abuse, the present study sought to determine the effect ...
C A, Rudoy, E J, Van Bockstaele
openaire   +2 more sources

UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity. [PDF]

PLoS ONE, 2010
The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis.Here we report that cyclooxygenase (COX) activity and prostaglandin E(2) (PGE(2)) are crucially involved in induction of UCP1 ...
Lise Madsen, Lone M Pedersen, Haldis Haukaas Lillefosse, Even Fjaere, Ingeborg Bronstad, Qin Hao, Rasmus K Petersen, Philip Hallenborg, Tao Ma, Rita De Matteis, Pedro Araujo, Josep Mercader, M Luisa Bonet, Jacob B Hansen, Barbara Cannon, Jan Nedergaard, Jun Wang, Jun Wang, Saverio Cinti, Peter Voshol, Stein Ove Døskeland, Karsten Kristiansen   +21 more
doaj   +1 more source

Functional selectivity of GPCR-directed drug action through location bias. [PDF]

, 2017
G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco, Huang, Bo, Irannejad, Roshanak, Mika, Delphine, Pessino, Veronica, von Zastrow, Mark, Wedegaertner, Philip B.   +6 more
core   +3 more sources

The (--)[3H]dihydroalprenolol binding to rat adipocyte membranes: an explanation of curvilinear Scatchard plots and implications for quantitation of beta-adrenergic sites

Journal of Lipid Research, 1982
In rat adipocyte membranes, both beta-adrenergic agonists and beta-adrenergic antagonists competed with (--)[3H]dihydroalprenolol for high affinity (KD 2-4 nM) and low capacity binding sites.
E M Dax, J S Partilla, R I Gregerman
doaj   +1 more source