Results 21 to 30 of about 94,283,903 (258)

The glucose lowering effects of CL 316,243 dissipate with repeated use and are rescued by cilostamide

Physiological Reports, 2022
Repeated activation of the beta 3 adrenergic receptor (β3AR) with the agonist CL 316,243 (CL) results in remodeling of white adipose tissue (WAT) characterized by increased mitochondrial enzymes and expression of uncoupling protein 1 (UCP1).
Kyle D. Medak, Greg L. McKie, Hesham Shamshoum, Ian Seguin, David C. Wright   +4 more
doaj   +1 more source

Intracellular cAMP Signaling Pathway via G_s Protein-Coupled Receptor Activation in Rat Primary Cultured Trigeminal Ganglion Cells

Biomedicines, 2023
G protein-coupled receptors in trigeminal ganglion (TG) neurons are often associated with sensory mechanisms, including nociception. We have previously reported the expression of P2Y12 receptors, which are Gi protein-coupled receptors, in TG cells ...
Yuki Kunioku, Maki Kimura, Takehito Ouchi, Kenichi Fukuda, Yoshiyuki Shibukawa   +4 more
doaj   +1 more source

Guanosine nucleotides regulate B2 kinin receptor affinity of agonists but not of antagonists: Discussion of a model proposing receptor precoupling to G protein [PDF]

, 2000
The effect of nucleotides on binding of the B2 kinin (BK) receptor agonist {[}H-3]BK and the antagonist {[}H-3]NPC17731 to particulate fractions of human foreskin fibroblasts was studied.
Er Faussner, Faussner, Alexander, Adelbert A. Roscher, Roscher, Adelbert A.   +3 more
core   +1 more source

Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes. [PDF]

PLoS ONE, 2010
The beta2-adrenergic receptor (beta2AR) is expressed on numerous cell-types including airway smooth muscle cells and cardiomyocytes. Drugs (agonists or antagonists) acting at these receptors for treatment of asthma, chronic obstructive pulmonary disease,
Alfredo Panebra, Wayne C Wang, Molly M Malone, Demar R G Pitter, Scott T Weiss, Gregory A Hawkins, Stephen B Liggett   +6 more
doaj   +1 more source

Plain language summary of safety and symptom improvement with vibegron in people with overactive bladder: results from the EMPOWUR study

Journal of Comparative Effectiveness Research, 2023
What is this summary about? This is a plain language summary of an article originally published in the Journal of Urology. Overactive bladder (also called OAB) has been treated with the same type of medicine for more than 40 years.
David Staskin, Jeffrey Frankel, Steven G Gregg, Susann Varano, Janet Owens-Grillo   +4 more
doaj   +1 more source

alpha 1- and beta 2-adrenergic receptor expression in the Madin-Darby canine kidney epithelial cell line. [PDF]

, 1983
The Madin-Darby canine kidney (MDCK) cell line, derived from distal tubule/collecting duct, expresses differentiated properties of renal tubule epithelium in culture.
M D Snavely, Meier, KE, Brown, SL, S L Brown, P A Insel, Snavely, MD, K E Meier, J H Brown, Brown, JH, Insel, PA   +9 more
core   +1 more source

Advancements in Beta-Adrenergic Therapy and Novel Personalised Approach for Portal Hypertension: A Narrative Review

Life
Liver cirrhosis is a chronic progressive disease marked by the transition from a compensated to a decompensated stage, associated with severe complications.
Raluca-Ioana Avram, Horia Octav Minea, Laura Huiban, Ioana-Roxana Damian, Mihaela-Cornelia Muset, Simona Juncu, Cristina Maria Muzica, Sebastian Zenovia, Ana Maria Singeap, Irina Girleanu, Carol Stanciu, Anca Trifan   +11 more
doaj   +1 more source

Overactive bladder [version 1; referees: 3 approved]

F1000Research, 2015
Overactive bladder syndrome is highly prevalent, and increasingly so with aging. It is characterized by the presence of urinary urgency, and can be associated with incontinence, increased voiding frequency, and nocturia.
Karen M. Wallace, Marcus J. Drake
doaj   +1 more source

Adrenergic lipolysis in guinea pig is not a beta 3-adrenergic response: comparison with human adipocytes

, 1994
beta 3-Adrenoceptor agonists are potent lipolytic activators in rats, but they are only weak stimulators in human adipocytes, indicating interspecies differences in the adrenergic regulation of lipid mobilization.
J. Galitzky, I. Castan, C. Carpene, J. Moratinos, M. Lafontan, P. Collon   +5 more
core   +1 more source

The effect of adding inhaled corticosteroids to tiotropium and long-acting beta(2)-agonists for chronic obstructive pulmonary disease (Review) [PDF]

, 2011
BackgroundLong-acting bronchodilators comprising long-acting beta(2)-agonists and the anticholinergic agent tiotropiumare commonly used, either on their own or in combination, for managing persistent symptoms of chronic obstructive pulmonary disease ...
Christopher J Cates, Karner, C, Cates, CJ, Charlotta Karner   +3 more
core   +1 more source