Results 1 to 10 of about 142 (116)

Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo. [PDF]

PLoS ONE, 2010
RATIONALE: Previous in vitro research demonstrated that ascorbate enhances potency and duration of activity of agonists binding to alpha 1 adrenergic and histamine receptors.
Patrick F Dillon, Robert Root-Bernstein, N Edward Robinson, William M Abraham, Catherine Berney   +4 more
doaj   +1 more source

The Role of Beta-Adrenergic Receptors in Depression and Resilience

Biomedicines, 2022
Norepinephrine is a catecholamine neurotransmitter that has been extensively implicated in the neurobiology of major depressive disorder (MDD). An accumulating body of evidence indicates that investigations into the action of norepinephrine at the ...
Hongxing Zhang, Mengqiao Cui, Jun-Li Cao, Ming-Hu Han   +3 more
doaj   +1 more source

Urothelial beta‐3 adrenergic receptors in the rat bladder [PDF]

Neurourology and Urodynamics, 2010
Abstract Aims To investigate the distribution of beta‐3 adrenergic receptors (β 3 ARs) in the rat bladder and to examine the contribution of urothelial β 3 ARs to agonist‐induced ...
F Aura, Kullmann, Thomas R, Downs, Debra E, Artim, Brian J, Limberg, Mansi, Shah, Dan, Contract, William C, de Groat, Jan S, Rosenbaum   +7 more
openaire   +2 more sources

Social isolation increases metabolic rate in the transition of light- to dark- phase and advances Rev-erb-α expression in brown adipose tissue to regulate daily rhythm of core body temperature in mice

Journal of Photochemistry and Photobiology, 2023
Mammals use social thermoregulation to maintain the core body temperature (Tc) at a lower energy cost. Brown adipose tissue (BAT) plays a crucial role in thermoregulation.
Paola Fernandes, Hellen Nunes, Tamires Amorim Marinho, Pietra Souza Barsanele, Maria Nathália Moraes, Maristela de Oliveira Poletini   +5 more
doaj   +1 more source

Targeting of beta adrenergic receptors results in therapeutic efficacy against models of hemangioendothelioma and angiosarcoma.

PLoS ONE, 2013
Therapeutic targeting of the beta-adrenergic receptors has recently shown remarkable efficacy in the treatment of benign vascular tumors such as infantile hemangiomas.
Jessica M Stiles, Clarissa Amaya, Steven Rains, Dolores Diaz, Robert Pham, James Battiste, Jaime F Modiano, Victor Kokta, Laura E Boucheron, Dianne C Mitchell, Brad A Bryan   +10 more
doaj   +1 more source

Preponderance of alpha 2- over beta 1-adrenergic receptor sites in human fat cells is not predictive of the lipolytic effect of physiological catecholamines

Journal of Lipid Research, 1983
Adrenergic control of human fat cell lipolysis is mediated by two kinds of receptor sites that are simultaneously stimulated by physiological amines. To establish a correlation between the binding characteristics of the receptor and biological functions,
M Lafontan, M Berlan, A Villeneuve
doaj   +1 more source

Computational screening and in silico docking analysis of non-selective beta-blockers over beta-3 adrenergic receptors

National Journal of Physiology, Pharmacy and Pharmacology, 2020
Background: Beta-blockers with additional beneficial activity such as beta-2 agonist and alpha-1 blocking activity are developed and available as the third-generation beta-blockers for effective management of hypertension with comorbid conditions ...
Haripriya Sadam, Subash K R
doaj   +1 more source

Optical control of the β2-adrenergic receptor with opto-prop-2: A cis-active azobenzene analog of propranolol

iScience, 2022
Summary: In this study, we synthesized and evaluated new photoswitchable ligands for the beta-adrenergic receptors β1-AR and β2-AR, applying an azologization strategy to the first-generation beta-blocker propranolol. The resulting compounds (Opto-prop-1,
Reggie Bosma, Nicola C. Dijon, Yang Zheng, Hannes Schihada, Niels J. Hauwert, Shuang Shi, Marta Arimont, Rick Riemens, Hans Custers, Andrea van de Stolpe, Henry F. Vischer, Maikel Wijtmans, Nicholas D. Holliday, Diederik W.D. Kuster, Rob Leurs   +14 more
doaj   +1 more source

Norepinephrine controls both torpor initiation and emergence via distinct mechanisms in the mouse. [PDF]

PLoS ONE, 2008
Some mammals, including laboratory mice, enter torpor in response to food deprivation, and leptin can attenuate these bouts of torpor. We previously showed that dopamine beta-hydroxylase knockout (Dbh -/-) mice, which lack norepinephrine (NE), do not ...
Steven J Swoap, David Weinshenker
doaj   +1 more source

The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis

Frontiers in Endocrinology, 2021
BackgroundInsulin resistance is a metabolic disorder that occurs in type 2 diabetes mellitus and obesity. Genetic factors such as β3-adrenoceptor polymorphism (Trp64Arg) may be involved in IR and insulin secretion.
Hai-Dan Wang, Cai-Shun Zhang, Man-Wen Li, Qian Lin, Qing Zhang, De-Feng Liu, Zheng-Ye Ma, Jing Dong, Jing Dong   +8 more
doaj   +1 more source