Results 31 to 40 of about 93,900,112 (260)

Potential off-target effects of beta-blockers on gut hormone receptors: In silico study including GUT-DOCK-A web service for small-molecule docking.

PLoS ONE, 2019
The prolonged use of many currently available drugs results in the severe side effect of the disruption of glucose metabolism leading to type 2 diabetes mellitus (T2DM.
Pawel Pasznik, Ewelina Rutkowska, Szymon Niewieczerzal, Judyta Cielecka-Piontek, Dorota Latek   +4 more
doaj   +1 more source

Stress hormones promote DNA damage in human oral keratinocytes

Scientific Reports, 2021
Chronic stress increases the systemic levels of stress hormones norepinephrine and cortisol. As well as tobacco-specific carcinogen NNK (4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone), they can induce expressive DNA damage contributing to the cancer ...
Vitor Bonetti Valente, Diovana de Melo Cardoso, Giseli Mitsuy Kayahara, Giovana Barros Nunes, Kellen Cristine Tjioe, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Sandra Helena Penha Oliveira, Gisele Zoccal Mingoti, Daniel Galera Bernabé   +9 more
doaj   +1 more source

Norepinephrine directly activates adult hippocampal precursors via beta(3)-adrenergic receptors [PDF]

, 2010
Adult hippocampal neurogenesis is a critical form of cellular plasticity that is greatly influenced by neural activity. Among the neurotransmitters that are widely implicated in regulating this process are serotonin and norepinephrine, levels of which ...
Nandam, L. S., Bartlett, P. F., Mackay, E. W., V. A. Vaidya, Marathe, Swananda V., Nandam, L. Sanjay, Marathe, S. V., L. S. Nandam, Vaidya, V. A., D. J. Jhaveri, Jhaveri, Dhanisha J., P. F. Bartlett, Mackay, Eirinn W., Vaidya, Vidita A., Hamlin, A. S., Bartlett, Perry F., E. W. Mackay, Hamlin, Adam S., A. S. Hamlin, Jhaveri, D. J., S. V. Marathe   +20 more
core   +1 more source

Brief Communication: Histological Assessment of Nonhuman Primate Brown Adipose Tissue Highlights the Importance of Sympathetic Innervation

Journal of Obesity, 2023
Objective. The objective of this study was to functionally analyze the correlation of key histological features in brown adipose tissue (BAT) with clinical metabolic traits in nonhuman primates. Methods.
Abigail G. Williams, Masha Long, Kylie Kavanagh   +2 more
doaj   +1 more source

Intracellular cAMP Signaling Pathway via G_s Protein-Coupled Receptor Activation in Rat Primary Cultured Trigeminal Ganglion Cells

Biomedicines, 2023
G protein-coupled receptors in trigeminal ganglion (TG) neurons are often associated with sensory mechanisms, including nociception. We have previously reported the expression of P2Y12 receptors, which are Gi protein-coupled receptors, in TG cells ...
Yuki Kunioku, Maki Kimura, Takehito Ouchi, Kenichi Fukuda, Yoshiyuki Shibukawa   +4 more
doaj   +1 more source

Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation. [PDF]

PLoS ONE, 2014
Spontaneous calcium waves in cardiac myocytes are caused by diastolic sarcoplasmic reticulum release (SR Ca(2+) leak) through ryanodine receptors.
Jerry Curran, Lifei Tang, Steve R Roof, Sathya Velmurugan, Ashley Millard, Stephen Shonts, Honglan Wang, Demetrio Santiago, Usama Ahmad, Matthew Perryman, Donald M Bers, Peter J Mohler, Mark T Ziolo, Thomas R Shannon   +13 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Impact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer’s disease

Journal of Neuroinflammation
Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and it also regulates neuroinflammation. We previously demonstrated behavioral and immunomodulatory effects of beta-adrenergic pharmacology in ...
Andrew K. Evans, Heui Hye Park, Claire E. Woods, Rachel K. Lam, Daniel Ryskamp Rijsketic, Christine Xu, Emily K. Chu, Peter Ciari, Sarah Blumenfeld, Laura M. Vidano, Nay Lui Saw, Boris D. Heifets, Mehrdad Shamloo   +12 more
doaj   +1 more source

STUDYING THE FEATURES OF BETA-ADRENOREACTION IN PATIENTS BEFORE AND AFTER INTERVENTIONAL TREATMENT OF ATRIAL FIBRILLATION

Байкальский медицинский журнал, 2023
BACKGROUNDIt is known that the autonomic nervous system plays a significant role in the onset, maintenance and arrest of atrial fibrillation. Its influence is deter­mined by a combination of direct and indirect ef­fects on the special conductive cardiac ...
E A Archakov, R E Batalov, O R Eshmatov, E F Muslimova, S A Afanasiev, S V Popov   +5 more
doaj   +1 more source