Results 11 to 20 of about 108,842 (256)

Identifying Ligand Binding Conformations of the β2-Adrenergic Receptor by Using Its Agonists as Computational Probes [PDF]

, 2011
Recently available G-protein coupled receptor (GPCR) structures and biophysical studies suggest that the difference between the effects of various agonists and antagonists cannot be explained by single structures alone, but rather that the conformational
Ashley M. Buckle, B Isin, B Isin, B Isin, Basak Isin, BK Kobilka, BK Kobilka, C Gales, CD Strader, CD Strader, CD Strader, DL Farrens, DM Rosenbaum, DM Rosenbaum, DS Han, E Reiter, FZ Chung, G Liapakis, G Liapakis, G Swaminath, G Swaminath, Guillermina Estiu, GV Paolini, HW Choe, I Bahar, JA Javitch, JC Phillips, JE Olsson, JJ Liu, JP Overington, K Palczewski, K Wieland, KA Reynolds, L Shi, LM Luttrell, LS Barak, M Arakawa, M Azzi, MA Yildirim, MP Bokoch, MS Johnson, O Fritze, Olaf Wiest, P Ghanouni, PG Strange, R Nygaard, R Seifert, RA Friesner, RA Friesner, RO Dror, S Ahuja, S Bhattacharya, S Ludeke, SA Green, SG Rasmussen, SG Rasmussen, SG Rasmussen, T Palanche, TD Romo, U Gether, V Cherezov, X Deupi, X Yao, X Zhang, Zoltán N. Oltvai   +64 more
core   +10 more sources

Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection [PDF]

Elife 10 (2021): e61700, 2020
In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the viral replication phase is often followed by hyperinflammation, which can lead to acute respiratory distress syndrome, multi-organ failure, and death. We previously demonstrated that alpha-1 adrenergic receptor ($\alpha_1$-AR) antagonists can prevent hyperinflammation and ...
arxiv   +1 more source

Use of an ultrashort-acting selective β1-adrenergic receptor antagonist esmolol in ear, nose and throat surgery [PDF]

Scripta Medica, 2022
Background / Aim: The concept of general balanced anaesthesia was devised in order to assure cardiovascular stability and fast post-anaesthesia recovery.
Lončar-Stojiljković Dragana, Maksimović Žana M., Đurić Marko   +2 more
doaj   +1 more source

Novel Mutants of the Human β1-Adrenergic Receptor Reveal Amino Acids Relevant for Receptor Activation [PDF]

, 2006
Activation of G protein-coupled receptors like the beta(1)-adrenergic receptor results in conformational changes that ultimately lead to signal propagation through a G protein to an effector like adenylyl cyclase.
Björn Behr, Carsten Hoffmann, Gianluca Ottolina, Karl-Norbert Klotz   +3 more
core   +1 more source

Effects of β-Adrenergic Antagonists on Chemoradiation Therapy for Locally Advanced Non-Small Cell Lung Cancer

Journal of Clinical Medicine, 2019
Introduction: Locally advanced non-small cell lung cancer (NSCLC) is highly resistant to chemoradiotherapy, and many cancer patients experience chronic stress.
K. Chaudhary, Sherry X. Yan, S. Heilbroner, J. Sonett, M. Stoopler, C. Shu, B. Halmos, T. Wang, T. Hei, Simon K. Cheng   +9 more
semanticscholar   +1 more source

CARVEDILOL AS PRIMARY PROPHYLAXIS FOR GASTRIC VARICEAL BLEEDING IN PORTAL HYPERTENSION MODEL IN RATS

ABCD: Arquivos Brasileiros de Cirurgia Digestiva, 2020
Background: Portal hypertension (PH) can be measured indirectly through a hepatic vein pressure gradient greater than 5 mmHg. Cirrhosis is the leading cause for PH and can present as complications ascites, hepatic dysfunction, renal dysfunction, and ...
Andressa de Souza BERTOLDI, Camila Roginski GUETTER, Gabriel Antonio COLTRO, Larissa Maria VOSGERAU, Laura Maria Viscardi BRIGHENTI, Natália Izycki FAUAT, Fernando Bermudez KUBRUSLY, Camila Aparecida Moraes MARQUES, Luiz Fernando KUBRUSLY   +8 more
doaj   +2 more sources

Analgesic Efficacy of Perioperative Esmolol as an Adjunct to Morphine in Mastectomy- A Prospective Observational Study [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Multimodal analgesia with opioids as the prime component is the mainstay of postoperative analgesia for mastectomy, which can lead to many opioid related unwanted side-effects.
JOSE TANIA, VADAKKOOT RAGHAVAN HEMA, Prabhakaran Vineetha   +2 more
doaj   +1 more source

Esmolol as an adjunct to general balanced anaesthesia in neurosurgery [PDF]

Scripta Medica, 2021
Background/Aim: In surgery, and especially in the neurosurgical operations, maintenance of cardiovascular stability during and in the phase of the immediate postoperative recovery is of vital importance.
Lončar-Stojiljković Dragana, Maksimović Žana M., Đurić Marko   +2 more
doaj   +1 more source

Norepinephrine and dopamine increase motility, biofilm formation and virulence of Vibrio harveyi [PDF]

, 2014
Vibrio harveyi is one of the major pathogens of aquatic organisms, affecting both vertebrates and invertebrates, and causes important losses in the aquaculture industry.
Bossier, Peter, Defoirdt, Tom, Nguyen Duc, Quynh Anh, Yang, Qian   +3 more
core   +2 more sources

Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder

Journal of Pharmacology and Experimental Therapeutics, 2017
Although the physiologic role of muscarinic receptors in bladder function and the therapeutic efficacy of muscarinic antagonists for the treatment of overactive bladder are well established, the role of β3-adrenergic receptors (β3ARs) and their potential
J. D. Salvo, Hiroshi Nagabukuro, L. Wickham, Catherine Abbadie, Julie A. DeMartino, A. Fitzmaurice, Loise N. Gichuru, Alison A. Kulick, M. Donnelly, Nina Jochnowitz, Amanda L Hurley, A. Pereira, Anthony Sanfiz, G. Veronin, Katherine L. Villa, John W. Woods, Beata Zamlynny, Emanuel Zycband, G. Salituro, Tara L. Frenkl, Ann E. Weber, S. Edmondson, M. Struthers   +22 more
semanticscholar   +1 more source