Results 271 to 280 of about 115,479 (330)

Longitudinal sex differences in cerebrovascular ageing in older adults: results from the brain in motion study

The Journal of Physiology, EarlyView.
Abstract figure legend Longitudinal assessment of sex differences in cerebrovascular ageing over a ∼6 year period: the Brain in Motion study. Cerebrovascular function was assessed at baseline (T1) and at a follow‐up (T2) ∼6 years later, at rest, during euoxic hypercapnia and while engaging in submaximal exercise. Over the follow‐up period females had a
Connor Snow, Alison M. H. Donald, Kian M. Pelechaty, Jordan Gibson, Michael D. Hill, Jean M. Rawling, Jayna Holroyd‐Leduc, Kara Nerenberg, Jessalyn K. Holodinsky, R. Stewart Longman, Marc J. Poulin   +10 more
wiley   +1 more source

A positive allosteric modulator of the β1AR with antagonist activity for catecholaminergic polymorphic ventricular tachycardia. [PDF]

J Clin Invest
Grogan A, Perelli RM, Ahn S, Jiang H, Jyothidasan A, Sood D, You C, Israel DI, Shaginian A, Chen Q, Liu J, Wang J, Steyaert J, Kahsai AW, Landstrom AP, Lefkowitz RJ, Rockman HA.   +16 more
europepmc   +1 more source

A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists

, 1991
S Suryanarayana, David A. Daunt, Mark von Zastrow, Brian K. Kobilka   +3 more
openalex   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies.
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Chronic stress-related neuroendocrine mediators and ovarian cancer. [PDF]

Discov Oncol
Du H, Yu G, Hu R, Du J, Liu C.
europepmc   +1 more source

Selective RyR2 inhibition reduces arrhythmia susceptibility in human cardiac slices

The Journal of Physiology, EarlyView.
Abstract figure legend ent‐Vert selectively inhibits RyR2‐mediated sarcoplasmic reticulum (SR) Ca2+ leak and prevents triggered activity in human cardiac slices. A, in human ventricular slices exposed to β‐adrenergic stimulation with Iso and RyR2 sensitization with caffeine, RyR2 channels become hyperactive, leading to Ca2+ sarcoplasmic leak and ...
Micah K. Madrid, Katy A. Trampel, Batool Salman, Sharon A. George, Tatiana Efimova, Bjorn Knollmann, Igor R. Efimov   +6 more
wiley   +1 more source

Performance-Enhancing Effects of Inhaled Medications: Implications for Heart, Muscle Function, and Doping Detection in Athletes. [PDF]

J Funct Morphol Kinesiol
Cricco R, Segreti A, Stirpe E, Ferro A, Ciancio M, Cipriani F, Fossati C, Ussia GP, Pigozzi F, Grigioni F.   +9 more
europepmc   +1 more source

Management Strategies for Refractory Esophageal Varices

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Refractory esophageal varices that are difficult to control or unresponsive to endoscopic treatment remain a major clinical challenge in the management of portal hypertension. This review provides a comprehensive overview of treatment strategies for these cases, along with a comparative analysis of the American Association for the Study of ...
Keita Maki, Hiroaki Haga, Yoshiyuki Ueno
wiley   +1 more source

Pharmacological interventions for anthracycline-induced cardiotoxicity in breast cancer: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Breast Cancer Res Treat
Vacharanukrauh P, Miller KJ, Alif SM, Grace F, Rahman MA.   +4 more
europepmc   +1 more source

Ximenia americana L. From Popular Use to Anti‐Inflammatory Activities: A Comprehensive Review

Food Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT Ximenia americana (L.), known as “yellow plum,” “sea lemon,” or “Brazilian plum,” is a tropical/subtropical plant widely used in traditional medicine. Its roots, leaves, flowers, stem, and fruits are traditionally employed to treat various inflammatory disorders.
Bruno Anderson F. Silva, Maria Gabriely de Lima Silva, Eduardo S. Silva, Lucas Yure S. Silva, Renata Torres Pessoa, Silvio C. Alves‐Júnior, Jullyana S. S. Quintans, Laurent Picot, Irwin Rose A. Menezes, Lucindo J. Quintans‐Júnior   +9 more
wiley   +1 more source