Results 171 to 180 of about 136,170 (301)

Investigating the Link Between Objective Sleep Metrics and Cerebral Small Vessel Disease in a Population‐Based Cohort

Journal of Sleep Research, EarlyView.
ABSTRACT Cerebral small vessel disease (CSVD), a disorder that affects the cerebral microvasculature, is commonly associated with aging and may contribute to dementia and stroke. Increasing evidence suggests a link between CSVD and sleep disturbances, but the association remains poorly understood.
Mareike Ludwig, Arne Böttcher, Marvin Petersen, Felix Leonard Nägele, Maximilian Schell, Jacob Friedrich Clausen, Götz Thomalla, Ines Schäfer, Alena Haack, Christian Betz, Anna Sophie Hoffmann, Bastian Cheng   +11 more
wiley   +1 more source

Drug- and patient-specific neurological risk profiles of α1-adrenergic blockers: evidence from FAERS and external validation in JADER. [PDF]

Ther Adv Drug Saf
Hai X, Huang L.
europepmc   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Survival benefit of concurrent beta-blocker use in cancer patients treated with radiotherapy: A systematic review and meta-analysis. [PDF]

Medicine (Baltimore)
Xu W, Xin Y, Yang X, Wu M, Chen H, Lu X, Guo Y, Yu D, Zhou F.   +8 more
europepmc   +1 more source

Targeting Overweight and Obesity Phenotypes for Secondary Prevention of Cardiovascular Disease: A Call to Action for the Middle East and Beyond

Obesity Reviews, EarlyView.
ABSTRACT Although there are conflicting clinical data on the efficacy of weight reduction in reducing secondary events in patients with comorbid overweight and obesity (OAO) and cardiovascular disease (CVD), there is excellent epidemiological and biological evidence of a cause–effect relationship between OAO, CVD, and other systemic complications ...
Wael Almahmeed, Juan S. Barajas‐Gamboa, Mohammad Zubaid, Ebaa Al Ozairi, Abdullah Shehab, Khalid Al‐Rasadi, Charbel Abi Khalil, Noor Al Busaidi, Fahad Al Sindi, Zuhier Awan, Tomader Ali, Khaldoon Al‐Humood, Fatheya Al Awadi, Mohammed Al Hadad, Manal Al Kindi, Khalid Al Habib, Khalid Al Waili, Maryam Alsaeed, Adel Tash, Hani Sabbour   +19 more
wiley   +1 more source

Development of pH-Sensitive β‑Adrenergic Receptor Antagonists. [PDF]

ACS Pharmacol Transl Sci
Braun T, Pröll T, Weißing N, Hübner H, Gmeiner P.   +4 more
europepmc   +1 more source

Rethinking Global Obesity Guidelines: Integrating Evidence, Equity and Precision (2014–2026)

Obesity Reviews, EarlyView.
Challenges and evidence in obesity guidelines. ABSTRACT Obesity remains a global health crisis characterized by substantial heterogeneity in diagnosis, management, and policy implementation. Although numerous national and international clinical practice guidelines have been published over the past decade, their translation into evidence‐based and ...
Rosero‐Revelo Ricardo, Tamayo Mateo, Henao Diana, Juan P. Polanco, Cortés David, Juan C. Alba, Giha Valeria, Camargo Camilo, Hernández Eder, Correa Ricardo, Nassar Ricardo, Cabandugama Peminda, Marcio L. Griebeler, Burguera Bartolome   +13 more
wiley   +1 more source

Assessment of functional reserves of the autonomous control mechanisms on the basis of the heart rate variability analysis under the combined influence of blockers of cardiac activity autonomous control and hypoxia

Current Issues in Pharmacy and Medical Sciences
We have chosen the introduction of the blocker of M-cholinergic receptors (atropine) and blocker of ß-adrenergic receptor (propranolol) in different doses as a functional loading under hypoxia.
LYUBOV Panina, Mechyslav Gzhegotskyi, Yuriy Petryshyn, Oleksiy Mysakovets, Ostap Mysakovets   +4 more
doaj  

Leveraging the perioperative window in pancreatic cancer: lessons from the PROSPER trial. [PDF]

Gland Surg
Bethel F, Corona A, Hosein P, Datta J.
europepmc   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source