Results 111 to 120 of about 116,963 (259)

Structural Mechanism of an Efficacy Photoswitch Targeting the β₂-adrenergic Receptor. [PDF]

Angew Chem Int Ed Engl
Stipp R, Bertrand Q, Trabuco M, Duran-Corbera A, Ignazzitto MT, Glover H, Stierli F, Catena J, Carrillo M, Hartmann S, Seidel HP, Mulder M, Mason T, Kondo Y, Wranik M, Appleby M, Sager C, Sierra R, Gate G, Schleissner P, Cheng X, Weinert T, Cheng R, Mous S, Beale JH, Kepa M, Llebaria A, Hennig M, Rovira X, Standfuss J.   +29 more
europepmc   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

White matter hyperintensities are associated with locus coeruleus atrophy and astrocytic β₂-adrenergic receptor expression. [PDF]

Alzheimers Dement
Vidal V, Farías G, Delgado C, Delano PH, Vergara RC, Orellana P, Ossandón T, Crossley NA, Gonzalez-Campo C, Naismith SL, Gonzalez-Gomez R, Coronel-Oliveros C, Ibáñez A, Wainstein G, Sanders RD, Shine JM, Medel V.   +16 more
europepmc   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Electroacupuncture as an eosinophil-targeting treatment in ovalbumin-induced allergic rhinitis involving β₂-adrenergic receptor in a mouse model. [PDF]

Front Immunol
Quach TVB, Nguyen TV, Nguyen NCL, Lin CH, Chen YH.   +4 more
europepmc   +1 more source

Cancer Vaccine Development: Toward Artificial Intelligence‐Assisted Personalized Cell Membrane Nanovaccine

Small, EarlyView.
Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley   +1 more source

Adrenergic receptor activation triggers stress-induced dystonia in a CACNA1A mutant mouse model. [PDF]

Front Neurosci
Bohne P, Grömmke M, Rybarski M, Nair T, Mark MD.   +4 more
europepmc   +1 more source

Early Intervention Effects and Risk Factors for Residual Skin Changes in Infantile Hemangiomas

The Journal of Dermatology, EarlyView.
ABSTRACT Infantile hemangioma (IH) characteristically progresses through proliferative, involuting, and involuted phases, and typically undergoes spontaneous regression after the age of five. Therefore, the traditional management strategy has been based on a “wait‐and‐see policy”.
Kayoko Okuda, Motoki Nakamura, Reiko Nakamura, Sachiyo Takagi, Akimichi Morita   +4 more
wiley   +1 more source

Investigating the electrostatics underlying activation of the β₂ adrenergic receptor. [PDF]

Biochim Biophys Acta Biomembr
Montgomery JM, Lemkul JA.
europepmc   +1 more source

Impact of barometric pressure on blood pressure during dialysis: Introducing intradialytic time‐averaged cumulative systolic blood pressure (TACsBP‐inD) as a new metric

Therapeutic Apheresis and Dialysis, Volume 29, Issue 3, Page 525-534, June 2025.
Abstract Background Blood pressure is a crucial risk factor for hemodialysis patients, but the specific impact of weather factors, particularly barometric pressure, on blood pressure remains unclear. This study aims to examine the relationship between barometric pressure and blood pressure in hemodialysis patients. Methods We conducted a single‐center,
Kosaku Iwatsubo, Shouichi Fujimoto, Michikazu Nakai   +2 more
wiley   +1 more source