Results 41 to 50 of about 2,462,685 (262)

Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The etiology of postural orthostatic tachycardia syndrome (POTS) is yet to be established. The disorder is often misdiagnosed as chronic anxiety or a panic disorder because the autonomic failure in these patients is not severe.
William T. Gunning, Heather Kvale, Paula M. Kramer, Beverly L. Karabin, Blair P. Grubb   +4 more
doaj   +1 more source

Serum Activity Against G Protein–Coupled Receptors and Severity of Orthostatic Symptoms in Postural Orthostatic Tachycardia Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive heart rate increase on standing and orthostatic intolerance. Previous data indicate autoimmune involvement.
Isabella Kharraziha, Jonas Axelsson, Fabrizio Ricci, Giuseppe Di Martino, Margaretha Persson, Richard Sutton, Artur Fedorowski, Viktor Hamrefors   +7 more
doaj   +1 more source

The use of α1-adrenergic receptor antagonists in the prevention of adverse outcomes of COVID-19 infection in obese patients

Advances in Human Biology, 2022
Obesity is widely reported to be associated with a higher risk of the severity and worse clinical outcome of COVID-19. With the global prevalence of obesity, exploring the relationship between obesity and the severity of COVID-19 disease is of major ...
Auda Fares, Resul Toprak, Dieter Borrman, Julius R Ivester   +3 more
doaj   +1 more source

Comparison of the efficacy and complications of tolterodine and α-adrenergic receptor blockers in improving ureteral stent-related symptoms: A systematic review and meta-analysis.

PLoS ONE
ObjectiveWe conducted a systematic evaluation of the therapeutic efficacy and complications of tolterodine and α-adrenergic receptor blockers in alleviating ureteral stent-related symptoms.MethodsUntil August 2023, we conducted a comprehensive literature
Ming Liu, Shangjing Liu, Qiancheng Mao, Qingsong Zou, Yuanshan Cui, Jitao Wu   +5 more
doaj   +1 more source

Alpha adrenergic modulation on effects of norepinephrine transporter inhibitor reboxetine in five-choice serial reaction time task

Journal of Biomedical Science, 2009
The study examined the effects of a norepinephrine transporter (NET) inhibitor reboxetine (RBX) on an attentional performance test. Adult SD rats trained with five-choice serial reaction time task (5-CSRTT) were administered with RBX (0, 3.0 and 10 mg/kg)
Liu Yia-Ping, Lin Yu-Lung, Chuang Chia-Hsin, Kao Yu-Cheng, Chang Shang-Tang, Tung Che-Se   +5 more
doaj   +1 more source

Beta-adrenergic receptor 1 selective antagonism inhibits norepinephrine-mediated TNF-alpha downregulation in experimental liver cirrhosis. [PDF]

PLoS ONE, 2012
BACKGROUND: Bacterial translocation is a frequent event in cirrhosis leading to an increased inflammatory response. Splanchnic adrenergic system hyperactivation has been related with increased bacterial translocation. We aim at evaluating the interacting
Pedro Zapater, Isabel Gómez-Hurtado, Gloria Peiró, José Manuel González-Navajas, Irma García, Paula Giménez, Alba Moratalla, José Such, Rubén Francés   +8 more
doaj   +1 more source

Efficacy of the β2-adrenergic receptor is determined by conformational equilibrium in the transmembrane region

Nature Communications, 2012
Many drugs that target G-protein-coupled receptors (GPCRs) induce or inhibit their signal transduction with different strengths, which affect their therapeutic properties.
Yutaka Kofuku, Takumi Ueda, Junya Okude, Yutaro Shiraishi, Keita Kondo, M. Maeda, H. Tsujishita, I. Shimada   +7 more
semanticscholar   +1 more source

The role of spinal adrenergic receptors on the antinociception of ginsenosides in a rat postoperative pain model [PDF]

Korean Journal of Anesthesiology, 2013
BackgroundThe effect of spinal adrenergic and cholinergic receptors on the anti-nociceptive effect of intrathecal ginsenosides was determined in a rat postoperative pain model.MethodsCatheters were placed into the intrathecal space of male Sprague-Dawley
In Ji Kim, Cheon Hee Park, Seong Heon Lee, Myung Ha Yoon   +3 more
doaj   +1 more source

Structural Basis of the Diversity of Adrenergic Receptors

Cell Reports, 2019
Summary: Adrenergic receptors are highly homologous while at the same time display a wide diversity of ligand and G-protein binding, and understanding this diversity is key for designing selective or biased drugs for them.
Lu Qu, Qingtong Zhou, Yueming Xu, Yu Guo, Xiaoyu Chen, Deqiang Yao, Gye Won Han, Zhi-Jie Liu, Raymond C. Stevens, Guisheng Zhong, Dong Wu, Suwen Zhao   +11 more
doaj   +1 more source

β-Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

Journal of Neuroscience, 2011
Psychosocial stress is associated with altered immune function and development of psychological disorders including anxiety and depression. Here we show that repeated social defeat in mice increased c-Fos staining in brain regions associated with fear ...
E. Wohleb, M. Hanke, A. Corona, N. Powell, L. Stiner, M. Bailey, R. Nelson, J. Godbout, J. Sheridan   +8 more
semanticscholar   +1 more source