Results 171 to 180 of about 130,584 (225)
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The Journal of Pharmacology and Experimental Therapeutics, 1990
The effectiveness of presynaptic receptor agonists to inhibit the electrically evoked release of [3H]monoamines from brain slices is attenuated in the presence of blockade of neuronal uptake for the serotonin (5-HT) and the norepinephrine (NE) systems.
P, Blier, A M, Galzin, S Z, Langer
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The effectiveness of presynaptic receptor agonists to inhibit the electrically evoked release of [3H]monoamines from brain slices is attenuated in the presence of blockade of neuronal uptake for the serotonin (5-HT) and the norepinephrine (NE) systems.
P, Blier, A M, Galzin, S Z, Langer
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Psychopharmacology, 1993
Narcolepsy is currently treated with anti-depressants to control REM-related symptoms such as cataplexy and with amphetamine-like stimulants for the management of sleepiness. Both stimulant and antidepressant drugs presynaptically enhance monoaminergic transmission but both classes of compounds lack pharmacological specificity.
E, Mignot +5 more
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Narcolepsy is currently treated with anti-depressants to control REM-related symptoms such as cataplexy and with amphetamine-like stimulants for the management of sleepiness. Both stimulant and antidepressant drugs presynaptically enhance monoaminergic transmission but both classes of compounds lack pharmacological specificity.
E, Mignot +5 more
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Canadian Journal of Physiology and Pharmacology, 1977
The effect of neuronal-uptake inhibitors on the guanethidine-induced inhibition of responses of rabbit vas deferens to transmural stimulation was investigated. The twitch and sustained reponses were inhibited by about 70% by 1.2 × 10−5 M guanethidine.
L J, Huston, D S, Golko, D M, Paton
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The effect of neuronal-uptake inhibitors on the guanethidine-induced inhibition of responses of rabbit vas deferens to transmural stimulation was investigated. The twitch and sustained reponses were inhibited by about 70% by 1.2 × 10−5 M guanethidine.
L J, Huston, D S, Golko, D M, Paton
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Acta Physiologica Scandinavica, 1969
AbstractVarious nucleotides and metabolic inhibitors have been tested on the release, reuptake and net uptake of noradrenaline (NA) in isolated splenic nerve granules. Cytidine, inosine, and uridine triphosphate facilitated uptake of NA to a similar degree as adenosine diphosphate but less than adenosine triphosphate.
U S, von Euler, F, Lishajko
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AbstractVarious nucleotides and metabolic inhibitors have been tested on the release, reuptake and net uptake of noradrenaline (NA) in isolated splenic nerve granules. Cytidine, inosine, and uridine triphosphate facilitated uptake of NA to a similar degree as adenosine diphosphate but less than adenosine triphosphate.
U S, von Euler, F, Lishajko
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The Journal of Pharmacology and Experimental Therapeutics, 1970
Tricycic antidepressants, deoxypipradrol, methylphenidate and cocaine are competitive inhibitors of the uptake of norepinephrine by rabbit aortic strips. All have pKa. values greater than 8.5 and, therefore, are greater than 90% protonated and positively
R E, Maxwell +4 more
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Tricycic antidepressants, deoxypipradrol, methylphenidate and cocaine are competitive inhibitors of the uptake of norepinephrine by rabbit aortic strips. All have pKa. values greater than 8.5 and, therefore, are greater than 90% protonated and positively
R E, Maxwell +4 more
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Inhibitors of the Uptake of Norepinephrine by the Adrenergic Nerves in Rabbit Aorta
2015R. A. Maxwell +3 more
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Napamezole, an alpha-2 adrenergic receptor antagonist and monoamine uptake inhibitor in vitro.
The Journal of Pharmacology and Experimental Therapeutics, 1990Napamezole (2-[3,4-dihydro-2-naphthalenyl)methyl]-4,5-dihydro-1H- imidazole-monohydrochloride) is a selective alpha-2 adrenergic receptor antagonist and a monoamine re-uptake inhibitor in vitro. The alpha adrenergic antagonist activity of napamezole was determined in vitro in rat brain receptor binding assay using [3H]clonidine and [3H]prazosin for ...
M H, Perrone +3 more
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Psychopharmacology, 1988
Fluoxetine, a novel antidepressant compound that potently and selectively inhibits serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]-dihydroalprenolol [( 3H]-DHA) decreased significantly in frontal cortex layers.
W F, Byerley +5 more
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Fluoxetine, a novel antidepressant compound that potently and selectively inhibits serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]-dihydroalprenolol [( 3H]-DHA) decreased significantly in frontal cortex layers.
W F, Byerley +5 more
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Journal of Neurochemistry, 1993
Abstract: The aim of this study was to evaluate the effect of citalopram, a second generation antidepressant agent producing no β‐down‐regulation, on the receptors and second messenger systems related to noradrenergic transmission in the cerebral cortex of the rat.
I, Nalepa, J, Vetulani
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Abstract: The aim of this study was to evaluate the effect of citalopram, a second generation antidepressant agent producing no β‐down‐regulation, on the receptors and second messenger systems related to noradrenergic transmission in the cerebral cortex of the rat.
I, Nalepa, J, Vetulani
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Brain Research, 1987
Sertraline, a potent and selective inhibitor of serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]dihydroalprenolol ([3H]DHA) was reduced in cortex layers IV-VI.
W F, Byerley +5 more
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Sertraline, a potent and selective inhibitor of serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]dihydroalprenolol ([3H]DHA) was reduced in cortex layers IV-VI.
W F, Byerley +5 more
openaire +2 more sources