Results 71 to 80 of about 130,584 (225)

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

Endocrinological aspects of sarcopenic obesity. [PDF]

Ann Med
Minnetti M, Poggiogalle E, Frigerio F, Piciocchi C, Pierantozzi G, Di Vincenzo O, Pinto A, Gianfrilli D, Isidori AM, Migliaccio S, Donini LM.   +10 more
europepmc   +1 more source

Innovative Nanomaterial‐Based Approaches for the Recognition of Amphetamine in Attention Deficit Hyperactivity Disorder Management

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT The rising incidence of amphetamine misuse, particularly in the context of attention deficit hyperactivity disorder treatment, underscores the urgent need for sensitive and effective detection methods. This review examines innovative nanomaterial‐based approaches for AMP detection, emphasizing their advantages over conventional analytical ...
Ilghar Zeinaly, Ghazal Koohkansaadi, Majid Hassanzadeh‐Khanmiri, Ahmad Mobed, Saeid Charsouei, Arash Mohagheghi   +5 more
wiley   +1 more source

Quantitative [¹⁸F]FDOPA PET/CT for the characterization of biochemical phenotypes in paraganglioma and pheochromocytoma. [PDF]

EJNMMI Rep
Dahlmann P, Onkes M, Kunte S, Auer MK, Disko U, Wang K, Lottspeich C, Stüfchen I, Schweizer JROL, Mansour N, Brendel M, Schmid-Tannwald C, Fischer A, Nölting S, Auernhammer CJ, Reincke M, Bidlingmaier M, Werner RA, Kroiss M, Völter F.   +19 more
europepmc   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

Evolving strategies in obstructive hypertrophic cardiomyopathy: myosin inhibitors as monotherapy compared with beta-blockers. [PDF]

Heart Fail Rev
Grupper A, Sverdlov AL, Cheema BS, Nasrollahizadeh A, Hosseini K.   +4 more
europepmc   +1 more source

Impaired Adipose Anabolism in Pancreatic Cancer Cachexia Is Reversed by HuR Inhibition

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Cachexia is defined by chronic loss of fat and muscle, is a frequent complication of pancreatic ductal adenocarcinoma (PDAC) and negatively impacts patient outcomes. Nutritional supplementation cannot fully reverse tissue wasting, and the mechanisms underlying this phenotype are unclear.
Paige C. Arneson‐Wissink, Katherine Pelz, Beth Worley, Heike Mendez, Peter Pham, Parham Diba, Peter R. Levasseur, Grace McCarthy, Alex Chitsazan, Jonathan R. Brody, Aaron J. Grossberg   +10 more
wiley   +1 more source

Adipocyte Browning: A Promising Avenue in Anti-Obesity Therapy. [PDF]

Int J Mol Sci
Bae YA, Cheon HG.
europepmc   +1 more source

Extracellular and Membrane Protein: Structure, Biological Functions, Diseases, and an Emerging Modality for Drug Discovery

MedComm, Volume 7, Issue 4, April 2026.
Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao, Wenhao Yin, Jianjian Han, Huimin Wang, Zheng Liu, Lilong Liu, Wuxiang Mao   +6 more
wiley   +1 more source

Cinnamon-Derived Phytonutrients as Modulators of Ion Channels and G Protein-Coupled Receptor Signaling in Metabolic Diseases. [PDF]

Nutrients
Tjandrawinata RR, Rosari BP, Syahputra RA, Surya R, Nurkolis F.   +4 more
europepmc   +1 more source