Results 81 to 90 of about 130,584 (225)

Human cells for human proteins: Isotope labeling in mammalian cells in suspension for functional NMR studies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract In biological and biomedical research, the focus progressively moves towards difficult human proteins, which often can only be expressed in higher eukaryotic cells. Nuclear magnetic resonance (NMR) could contribute significantly to the understanding of important proteins as it is one of the most information‐rich methods.
Philip Rößler, Marco M. Ruckstuhl, Arnelle Löbbert, Timo Stühlinger, Lucia R. Franchini, Ching‐Ju Tsai, Roman Lichtenecker, Binesh Shrestha, Simon H. Rüdisser, Robert Konrat, Gebhard F. X. Schertler, Alvar D. Gossert   +11 more
wiley   +1 more source

6‐Nitrodopamine Potentiates Catecholamine‐Induced Ca2+i Release in Human Aortic Smooth Muscle and Modulates Vascular Smooth Muscle Contractility

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Background In vascular smooth muscle, rises in intracellular calcium [Ca2+]i drive contraction downstream of α1‐adrenoceptor activation via IP3. Endothelium‐derived 6‐nitrodopamine (6‐ND) augments cardiac catecholamine actions; however, its effect on [Ca2+]i is unknown.
José Britto‐Júnior, Antonio Tiago Lima, Shuaihua Qiao, Hou Fong Tang, Valerie Cardenas, Edson Antunes, Gilberto De Nucci, Albert Ferro   +7 more
wiley   +1 more source

A case report of blood pressure fluctuation, inverted Takotsubo cardiomyopathy, and pulmonary embolism: searching for a link. [PDF]

Eur Heart J Case Rep
Mazza A, Picariello C, De Luca M, Canova E, Zuin M.   +4 more
europepmc   +1 more source

PDE3 and PDE4 Isozyme-Selective Inhibitors Are Both Required for Synergistic Activation of Brown Adipose Tissue

Molecular Pharmacology, 2013
Stephen M. Kraynik, R. Miyaoka, J. Beavo
semanticscholar   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

British Journal of Pharmacology, Volume 183, Issue 7, Page 1404-1426, April 2026.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez, Luis Alberto Luévano‐Martínez, Abraham Méndez‐Fernández, Judith Bernal‐Ramírez, Carolina A. Morales‐Ochoa, Christian Silva‐Platas, Alfredo Cabrera‐Orefice, Ana C. Murrieta, José Luis Velasco‐Bolom, Gricelda Mendiola‐Garza, Flavio Contreras‐Torres, Guillermo Torre‐Amione, Ernesto A. Aiello, Gerardo García‐Rivas   +13 more
wiley   +1 more source

Lipid metabolic reprogramming in the tumor microenvironment and its mechanistic role in immunosuppressive cells. [PDF]

Front Immunol
Liu W, Wang Z, Li Z, Li S, Shi X, Xu Y, Wang J.   +6 more
europepmc   +1 more source

Detection of an Antagonist Bound to the Neurokinin a Receptor in Styrene–Maleic Acid Lipid Particles by 19F Ultrafast Magic‐Angle Spinning Nuclear Magnetic Resonance Spectroscopy

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
The detection of a fluorinated antagonist bound to the neurokinin A receptor by 19F ultrafast MAS NMR is demonstrated. Therefore, the receptor is purified by detergent‐free extraction by styrene maleic acid copolymer encapsulation and subsequently characterised.
Samuel Seidl, Aditya Prasad Patra, Chengkang Li, Johanna Becker‐Baldus, Stefanie Kaiser, Christoph Reinhart, Clemens Glaubitz   +6 more
wiley   +1 more source

Neuro-tumor interactions: Multi-dimensional mechanisms of neurotransmitter regulation in tumor immune evasion and metabolic reprogramming. [PDF]

World J Clin Oncol
Li ZK, Liao JL, Luo MR, Fang SJ, Huang WZ, Zhang DY.   +5 more
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, Volume 7, Issue 1, Page 21-31, March 2026.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Pharmacological Interventions for Orthostatic Hypotension: A Systematic Review. [PDF]

Cureus
Verma A, Saraya E, Haque MS, Senaratne M, Khan S, Kasagga A, Malasevskaia IA.   +6 more
europepmc   +1 more source