Results 51 to 60 of about 34,931 (220)

Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany

International Journal of Cancer, EarlyView.
Molecular tumor boards (MTB), interdisciplinary teams that use tumor genomic data to guide personalized treatment decisions, have emerged as a promising strategy in melanoma care, although their real‐world clinical impact remains uncertain. This retrospective study evaluated advanced melanoma patients to assess molecularly guided treatment ...
Glenn Geidel, Theresa Lowinus, Patrick Metzger, Rebecca Czurda, Vincent Schipperges, Ulrike Paul, Alessandra Rünger, Julian Kött, Isabel Heidrich, Saskia Lehr, Julia Kühn, Heiko Becker, Cornelius Miething, Martin Werner, Silke Laßmann, Justus Duyster, Tilman Brummer, Ronald Simon, Winfried Alsdorf, Maximilian Christopeit, Carsten Bokemeyer, Kilian Eyerich, Stefan W. Schneider, David Rafei, Melanie Börries, Frank Meiss, Christoffer Gebhardt   +26 more
wiley   +1 more source

An Excellent Clinical and Radiological Response Pattern to Pembrolizumab in a Patient With Metastatic Adrenocortical Carcinoma and Lynch Syndrome

IJU Case Reports
Introduction The prognosis of unresectable metastatic adrenocortical carcinoma is very poor. We report a case of Lynch syndrome accompanying metastatic adrenocortical carcinoma treated with pembrolizumab.
Yuki Shimozawa, Yosuke Yasuda, Emiko Sugawara, Ryosuke Oki, Kosuke Takemura, Tetsuya Urasaki, Ryo Fujiwara, Noboru Numao, Junji Yonese, Takeshi Yuasa   +9 more
doaj   +1 more source

MiR-486-3p was downregulated at microRNA profiling of adrenals of multiple endocrine neoplasia type 1 mice, and inhibited human adrenocortical carcinoma cell lines

Scientific Reports, 2021
Adrenocortical carcinoma is a rare aggressive disease commonly recurring regardless of radical surgery. Although data on genomic alterations in malignant tumors are accumulating, knowledge of molecular events of importance for initiation of ...
Su-Chen Li, Azita Monazzam, Masoud Razmara, Xia Chu, Peter Stålberg, Britt Skogseid   +5 more
doaj   +1 more source

P53 mutations in human adrenocortical neoplasms [PDF]

, 1994
The mechanisms of tumorigenesis of adrenocortical neoplasms have not been elucidated as yet. However, loss of heterozygosity at chromosomal locus 17p has been consistently observed in adrenocortical cancer.
Allolio, B., Chrousos, G. P., Karl, M., Linehan, M., Mastorakis, G., Reincke, Martin, Travis, W.   +6 more
core  

Outcome after resection of Adrenocortical Carcinoma liver metastases: a retrospective study [PDF]

, 2017
Background: Metastatic Adrenocortical Carcinoma (ACC) is a rare malignancy with a poor 5-year-survival rate (
Christine Spitzweg, Christoph-Thomas Germer, Felix Megerle, Johannes Baur, Marcus Quinkler, Martin Fassnacht, Matthias Kroiss, on behalf of the German Adrenocortical Carcinoma Study Group, Peter Nawroth, Timo Deutschbein, Tjark-Ole Büntemeyer, Ulrich Steger   +11 more
core   +1 more source

Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development

Environmental Toxicology, EarlyView.
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo, Patricia Meade, Irene Jiménez‐Salvador, Carmen Hernández‐Ainsa, Eldris Iglesias, Alba Pesini, Nuria Garrido‐Pérez, Sonia Emperador, David Pacheu‐Grau, Pilar Bayona‐Bafaluy, Eduardo Ruiz‐Pesini   +10 more
wiley   +1 more source

Efficacy of oral metformin in a patient with metastatic adrenocortical carcinoma: Examination of mechanisms and therapeutic implications

Rare Tumors, 2018
Although rare, adrenocortical carcinoma is among the most common tumors found in children with Li-Fraumeni syndrome and Li-Fraumeni-like syndrome, associated with germ-line mutations in the TP53 gene. In southern Brazil, one form of Li-Fraumeni syndrome,
RD Peixoto, LM Gomes, TT Sousa, DJ Racy, M Shigenaga, RA Nagourney   +5 more
doaj   +1 more source

Adrenocortical Carcinoma: Updates of Clinical and Pathological Features after Renewed World Health Organisation Classification and Pathology Staging

Biomedicines, 2021
Adrenocortical carcinoma (ACC) is a heterogenous group of diseases with different clinical behaviour between adult and paediatric patients. In addition, three histological variants, oncocytic, myxoid and sarcomatoid are noted on the recent World Health ...
Alfred King-yin Lam
doaj   +1 more source

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

Rapidly growing adrenal gland tumor in a female patient with a history of colon cancer [PDF]

Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor"
Adrenocortical carcinoma is a rare malignant disease, occurring in 0.5-2 per 1,000,000 cases annually. Clinical signs may arise due to autonomous hormonal hypersecretion by the tumor, but also due to local compressive symptoms in the abdomen. The success
Marković Bojan, Stojković Mirjana, Klet Sanja, Janić Tamara, Babić Jovana, Đurković Ivana, Nedeljković-Beleslin Biljana, Ćirić Jasmina, Žarković Miloš   +8 more
doaj   +1 more source