Results 61 to 70 of about 22,616 (177)

Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 10, October 2026.
This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen, Wenxi Yang, Yonghan Song, Yuanhao Zhang, Jia Ma, Tingyao Wang, Jijun Zheng, Hebin Zhang, Yiyao Liu, Jinhao Zeng   +9 more
wiley   +1 more source

Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development

Environmental Toxicology, Volume 41, Issue 10, Page 906-921, October 2026.
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo, Patricia Meade, Irene Jiménez‐Salvador, Carmen Hernández‐Ainsa, Eldris Iglesias, Alba Pesini, Nuria Garrido‐Pérez, Sonia Emperador, David Pacheu‐Grau, Pilar Bayona‐Bafaluy, Eduardo Ruiz‐Pesini   +10 more
wiley   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Immunological Features of Neuroendocrine Neoplasms and Adrenal Tumors

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Neuroendocrine neoplasms, which occur throughout the human body, as well as adrenocortical carcinoma and pheochromocytoma, which originate in the adrenal gland, are primarily classified as rare malignancies. Immunotherapy, including immune checkpoint inhibitors (ICIs), is generally not incorporated into the standard care protocols for these ...
Akihiro Ohmoto, Shunji Takahashi, Shigehisa Kitano   +2 more
wiley   +1 more source

Primary Hyperaldosteronism as a Cause of Resistant Hypertension: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT In young patients with resistant hypertension and hypokalemia, primary hyperaldosteronism should be suspected. Biochemical assessment and adrenal imaging could identify surgically curable aldosterone‐producing adenomas, and a normalization of blood pressure, potassium levels, and symptom resolution can be achieved through adrenalectomy.
Wasif Majeed Chaudhry, Shazia N. Ibnerasa, Waleed Ahmad, Mohammed Hammad Jaber Amin   +3 more
wiley   +1 more source

Abdominal wall metastasis in scar after open resection of an adrenocortical carcinoma

Clinics and Practice, 2011
A 42-year-old man patient presented with progressively increasing, occasionally painful lump in the left upper and central abdomen. Investigations revealed well-defined capsulated left adrenocortical carcinoma.
Nikhil Gupta, Umesh Bansal, Neha Mahajan, Maha Singh Yadav   +3 more
doaj   +1 more source

New evidences on the regulation of SF-1 expression by POD1/TCF21 in adrenocortical tumor cells

Clinics
OBJECTIVES: Transcription Factor 21 represses steroidogenic factor 1, a nuclear receptor required for gonadal development, sex determination and the regulation of adrenogonadal steroidogenesis.
Monica Malheiros França, Antonio M. Lerario, Maria Candida B.V. Fragoso, Claudimara Ferini Pacicco Lotfi   +3 more
doaj   +1 more source

Adrenocortical carcinoma: Single center experience

Urology Research and Practice, 2019
Objective: Adrenocortical carcinoma is an aggressive endocrine malignancy with an annual incidence of 0.5-2 cases per million. The most important factors that determine prognosis are tumor stage at the time of diagnosis and the success of surgery ...
Pınar Şişman, Ahmet Bilgehan Şahin, Hande Peynirci, Soner Cander, Özen Öz Gül, Erdinç Ertürk, Canan Ersoy   +6 more
doaj   +1 more source

Knockdown of SF-1 and RNF31 affects components of steroidogenesis, TGFβ, and Wnt/β-catenin signaling in adrenocortical carcinoma cells.

PLoS ONE, 2012
The orphan nuclear receptor Steroidogenic Factor-1 (SF-1, NR5A1) is a critical regulator of development and homeostasis of the adrenal cortex and gonads.
Anna Ehrlund, Philip Jonsson, Lise-Lotte Vedin, Cecilia Williams, Jan-Åke Gustafsson, Eckardt Treuter   +5 more
doaj   +1 more source

Central Adrenal Insufficiency Developing After Right Partial Nephrectomy Involving Ectopic Adrenocortical Adenoma Mimicking Right Renal Carcinoma and a Retrospective Diagnosis of Adrenal Cushing's Syndrome: A Case Report

IJU Case Reports
Introduction Ectopic adrenocortical adenomas that produce adrenal hormones and mimic renal cell carcinoma are extremely rare. Case Presentation A 49‐year‐old woman underwent partial nephrectomy of the upper pole of the kidney following a clinical ...
Kentaro Arinami, Sayaka Kikuchi, Nobumasa Ohara, Yurie Takizawa, Yohei Ikeda, Kozue Ito, Go Hasegawa, Noboru Hara, Tsutomu Nishiyama   +8 more
doaj   +1 more source