Results 61 to 70 of about 34,931 (220)

Imaging findings of primary adrenal tumors in pediatric patients

Diagnostic and Interventional Radiology, 2021
Apart from neuroblastomas, adrenal tumors are rarely seen in children. The most common adrenal tumors are adrenocortical carcinoma and pheochromocytoma.
H. Nursun Özcan, Aziz Anil Tan, Burak Ardicli, Berna Oguz, Saniye Ekinci, Tezer Kutluk, Mithat Haliloglu   +6 more
doaj   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

The PI3K/Akt Pathway in Tumors of Endocrine Tissues [PDF]

, 2016
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key driver in carcinogenesis. Defects in this pathway in human cancer syndromes such as Cowden’s disease and Multiple Endocrine Neoplasia result in tumors of endocrine tissues, highlighting its ...
Hague, Angela, Robbins, Helen Louise
core   +2 more sources

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Gel chromatographic characterization of immunoreactive adrenocorticotropin in patients with ACTH hypersecretion [PDF]

, 1989
We investigated the molecular size of circulating immunoreactive ACTH by gel chromatography in patients with ACTH hypersecretion due to various disorders of the hypothalamic-pituitary-adrenal axis.
A Chatelain, AC Hale, B Allolio, B. Allolio, H Imura, JL Doppmann, JW Findling, K Nakao, M Reincke, M Reincke, M Thoren, M. Reincke, PJ Fuller, RC Pedersen, RE Mains, RS Yalow, SJ Ratter, U. Deuß, W. Winkelmann, Y Yamada   +19 more
core   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

ACTH-producing adrenocortical carcinoma: an exceedingly rare diagnosis

Journal of the Egyptian National Cancer Institute
Background Adrenocortical carcinoma is a very rare endocrinopathy that has a poor prognosis and is frequently associated with ACTH-independent Cushing’s syndrome.
Miguel Saraiva, Raquel da Inez Correia, Sérgio Xavier Azevedo, José Ricardo Brandão, José Carlos Oliveira, Isabel Palma   +5 more
doaj   +1 more source

Hypertriglyceridemia and its impact on mitotane monitoring in adrenocortical carcinoma

Endocrinology, Diabetes & Metabolism Case Reports, 2023
Mitotane is used for treatment of advanced adrenocortical carcinoma. It is administered when the carcinoma is unresectable, metastasized, or at high-risk of recurrence after resection.
Sandra Martens, Bruno Lapauw
doaj   +1 more source

Gene expression profiling of human adrenocortical tumors using complementary deoxyribonucleic Acid microarrays identifies several candidate genes as markers of malignancy. [PDF]

, 2005
International audienceThe aim of this study was to identify predictor sets of genes whose over- or underexpression in human sporadic adrenocortical tumors would help to identify malignant vs.
Baudin, Eric, Berger, François,, Bertagna, Xavier, Bertherat, Jérôme, Chabre, Olivier, Cherradi, Nadia, De Fraipont, Florence, Defaye, Geneviève, El Atifi, Michelle, Feige, Jean-Jacques, Gicquel, Christine, Houlgatte, Rémi, Le Moigne, Gwennaelle, Plouin, Pierre-François   +13 more
core   +4 more sources

FOXA1 is a highly sensitive diagnostic marker for prostate cancer including small cell carcinoma of the prostate

Histopathology, EarlyView.
FOXA1 is a highly sensitive diagnostic marker for prostate cancer. Besides prostatic adenocarcinoma, it is also expressed in 57%–80% of metastatic or primary prostatic small cell carcinomas, which lose traditional prostatic markers including NKX3.1. Although it is less specific than NKX3.1, it can serve as a valuable adjunct for confirming prostatic ...
Jianping Zhao, Jun Yao, Hossein Hosseini, Ezra Baraban, Ruihe Lin, Charles C. Guo, Lei Huo, Wei Lu, Khaja Khan, Shufang Wang, Luisa Maren Solis Soto, Qingqing Ding   +11 more
wiley   +1 more source