Results 81 to 90 of about 34,931 (220)

A Multi‐Institutional Retrospective Study of 21 Dogs Having Undergone Hypofractionated Radiotherapy for Adrenal Tumours (2017–2024)

Veterinary and Comparative Oncology, Volume 24, Issue 2, Page 229-239, June 2026.
ABSTRACT Radiation therapy (RT) has emerged as a promising non‐surgical approach for treating canine adrenal tumours. This multi‐institutional, retrospective study describes clinical outcomes for 21 dogs having been prescribed a course of hypofractionated image‐guided intensity‐modulated RT (IMRT) entailing delivery of 25–35 Gy total in 5 fractions ...
Yen‐Hao Erik Lai, Michael S. Kent, Michael W. Nolan, Dah‐Renn Fu, Jayme S. Looper   +4 more
wiley   +1 more source

Aldosterone-Producing Adrenocortical Carcinoma with Co-Secretion of Cortisol and Estradiol: A Case Report

Journal of the ASEAN Federation of Endocrine Societies, 2018
Aldosterone-producing adrenocortical carcinoma comprises less than 7% of all functioning adrenocortical carcinomas. We report a rare case of adrenocortical carcinoma with a clinical picture of primary aldosteronism and subclinical Cushing’s syndrome and ...
Karen Lazaro, Perie Adorable-Wagan
doaj  

Adrenal carcinoma: a case report

Journal of Medical Case Reports, 2022
Background Adrenocortical carcinoma is a rare malignancy (0.5–2 cases/million/year) with a poor prognosis. Hypercortisolism, virilization, and compressive features are among the common presentations of adrenocortical carcinoma.
D. R. Abeynayake, Sopan V, K. J. C. Perera, A. Paramanantham, T. M. J. Munasinghe   +4 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, Volume 20, Issue 5, Page 1299-1322, May 2026.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Frontiers in Systemic Therapy for Unresectable or Metastatic Adrenocortical Carcinoma: Harnessing Novel Therapeutic Approaches

Clinical Medicine Insights: Oncology
Adrenocortical carcinoma is a rare, aggressive endocrine malignancy with limited effective systemic therapy options and an overall poor prognosis for unresectable or metastatic disease.
Adam E Singer, Nikhita Kathuria-Prakash, David Shabsovich, Lizette Garcia, Leland Damron, Allan J Pantuck, Alexandra Drakaki   +6 more
doaj   +1 more source

Decoding the Oncogenic Role of USP22 Through Pan‐Cancer Genomic and Epigenetic Analysis

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Ubiquitin‐specific protease 22, an important catalytic component of the human SAGA (Spt‐Ada‐GcN5 Acetyltransferase) complex, regulates the deubiquitination and methylation of histones, which in turn influences gene expression. Its overexpression alters gene regulation, transcription, cancer progression, and therapy resistance.
Uma Devi A., Prakash Kumar Shukla
wiley   +1 more source

A multi‐centre, prospective trial of a methylation‐based liquid biopsy for early detection of liver cancer in high‐risk populations

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Three hypermethylated cfDNA markers specific to liver cancer, RNF135, CHFR and PAX5, were identified in peripheral blood and used to construct a diagnostic model. The model achieved 94.43% sensitivity and 95.16% specificity in a large clinical validation cohort, with a sensitivity of 93.1% for stage‐I liver cancer. Abstract Background and aims Existing
Ruohan Zhang, Xinrong Yang, Guangming Li, Yinan Deng, Jibing Liu, Hongjun Gao, Jie Zhao, Jianwen Cheng, Xiaofei Zhao, Yang Yang, Zhen Wu, Shuangzhen Gu, Yang Wu, Zhongying Ma, Yanli Liu, Yan Kang, Guangpeng Zhou, Hua Li, Yonghong Zhang, Xiaoliang Han, Jia Fan, Jian Zhou, Kefeng Dou, Kaishan Tao   +23 more
wiley   +1 more source

Abdominal wall metastasis in scar after open resection of an adrenocortical carcinoma

Clinics and Practice, 2011
A 42-year-old man patient presented with progressively increasing, occasionally painful lump in the left upper and central abdomen. Investigations revealed well-defined capsulated left adrenocortical carcinoma.
Nikhil Gupta, Umesh Bansal, Neha Mahajan, Maha Singh Yadav   +3 more
doaj   +1 more source

Role of the mTOR pathway in normal and tumoral adrenal cells [PDF]

, 2010
The mammalian target of rapamycin (mTOR) is a kinase of the phosphoinositide 3-kinase (PI3Ks)/protein kinase B (PKB or AKT) signaling pathway, which is one of the most important intracellular mediators of the activity of growth factors receptors ...
Hofland, L.J. (Leo), Koetsveld, P.M. (Peter) van, Martino, M.C. (Maria Cristina) de, Pivonello, R. (Rosario)   +3 more
core   +1 more source

Adrenocortical neoplasia: evolving concepts in tumorigenesis with an emphasis on adrenal cortical carcinoma variants [PDF]

, 2011
Adrenocortical carcinoma (ACC) is a rare, heterogeneous malignancy with a poor prognosis. According to WHO classification 2004, ACC variants include oncocytic ACCs, myxoid ACCs and ACCs with sarcomatous areas. Herein, we provide a comprehensive review of
Ronald R. de Krijger, Thomas G. Papathomas   +1 more
core   +1 more source