Results 31 to 40 of about 33,580 (222)

Management of Cushing’s disease when surgery is a tricky option – a case report

Liječnički vjesnik, 2023
Cushing’s disease, a form of Cushing’s syndrome, is caused by excess ACTH production, a hormone that regulates cortisol production, by a benign tumor in the pituitary gland.
Lucija Vusić, Vedrana Verić, Matea Živko, Velimir Altabas   +3 more
doaj   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Recent Updates on the Diagnosis and Management of Cushing's Syndrome [PDF]

Endocrinology and Metabolism, 2018
Cushing's syndrome, a potentially lethal disorder characterized by endogenous hypercortisolism, may be difficult to recognize, especially when it is mild and the presenting features are common in the general population.
Lynnette K. Nieman
doaj   +1 more source

Real-word adrenocorticotropic hormone treatment for childhood-onset nephrotic syndrome

Frontiers in Pediatrics, 2023
BackgroundCurrent first-line anti-proteinuric treatments do not produce a satisfactory therapeutic effect in a considerable number of patients with nephrotic syndrome (NS).
Ying Wang, Ying Wang, Xiqiang Dang, Xiqiang Dang, Xiaochuan Wu, Xiaochuan Wu, Yongzhen Li, Yongzhen Li, Qingnan He, Xiaoyan Li, Xiaoyan Li   +10 more
doaj   +1 more source

Adrenocorticotropic Hormone-Secreting Pheochromocytoma.

Internal Medicine, 1998
A 41-year-old female had pheochromocytoma which secreted adrenocorticotropic hormone (ACTH). She was admitted to our hospital because of weight loss and excessive sweating. Not only urinary metanephrine but also plasma ACTH was extremely high. An abdominal echogram showed a cystic tumor in the left adrenal gland. An abdominal magnetic resonance imaging
SATO, Miki, WATANABE, Takayuki, ASHIKAGA, Takashi, TANEDA, Tsutomu, YAMAWAKE, Noriyoshi, NISHIZAKI, Mitsuhiro, ARIMURA, Akihiko, AZEGAMI, Nobuhisa, ARITA, Masataka, FUKUOKA, Hiroshi, KITAMURA, Hajime   +10 more
openaire   +3 more sources

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Ectopic Adrenocorticotropic Hormone–Secreting Metastatic Pancreatic Neuroendocrine Tumor Initially Presenting as Gastrinoma: A Case Report

Annals of Internal Medicine: Clinical Cases
Pancreatic neuroendocrine tumors (pNETs) account for 1% to 2% of all pancreatic malignancies; approximately one-third are associated with hormone secretion which can result in a range of symptoms. It is rare for pNETs to transform from secreting one type
Harshitha Dudipala, Matthew Kulke, Sara Meibom, Hussein Assi   +3 more
doaj   +1 more source

An Atraumatic Symphysiolysis with a Unilateral Injured Sacroiliac Joint in a Patient with Cushing’s Disease: A Loss of Pelvic Stability Related to Ligamentous Insufficiency?

Case Reports in Orthopedics, 2016
Glucocorticoids are well known for altering bone structure and elevating fracture risk. Nevertheless, there are very few reports on pelvic ring fractures, compared to other bones, especially with a predominantly ligamentous insufficiency, resulting in a ...
Andreas Höch, Philipp Pieroh, Faramarz Dehghani, Christoph Josten, Jörg Böhme   +4 more
doaj   +1 more source

How developmental stressors affect mitochondrial respiratory function: a systematic review and meta‐analysis

Biological Reviews, EarlyView.
ABSTRACT The environmental conditions organisms experience during early development can have powerful and sustained effects on morphology, physiology, behaviour, and performance. Such developmental effects can influence reproductive success, survival, and life‐history strategies and can be transmitted across generations (i.e.
Ondi L. Crino, Christopher R. Friesen, Geoffrey E. Hill, Dalton C. Leibold, Pablo Recio, Karine Salin, Kristoffer H. Wild, Daniel W.A. Noble   +7 more
wiley   +1 more source