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Bio‐adrenomedullin as a marker of congestion in patients with new‐onset and worsening heart failure [PDF]
Background Secretion of adrenomedullin (ADM) is stimulated by volume overload to maintain endothelial barrier function, and higher levels of biologically active (bio-) ADM in heart failure (HF) are a counteracting response to vascular leakage and tissue ...
Daan Kremer +2 more
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Adrenomedullin in hypertension
Current Hypertension Reports, 2000Introduction Adrenomedullin, a 52-amino acid peptide, was discovered in 1993 in human pheochromocytoma tissue. The initial report documented not only its structure, but also the fact that when the hormone was administered to experimental animals, it had a potent and long-lasting hypotensive effect.
R D, Troughton +4 more
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Regulatory Peptides, 2003
Adrenomedullin (AM) is a pluripotent hormone with structural similarities to calcitonin gene-related peptide (CGRP), which is expressed by many tissues in the body and shows a remarkable range of effects mediated by paracrine/autocrine and possibly endocrine mechanisms.
E, Zudaire, A, Martínez, F, Cuttitta
openaire +2 more sources
Adrenomedullin (AM) is a pluripotent hormone with structural similarities to calcitonin gene-related peptide (CGRP), which is expressed by many tissues in the body and shows a remarkable range of effects mediated by paracrine/autocrine and possibly endocrine mechanisms.
E, Zudaire, A, Martínez, F, Cuttitta
openaire +2 more sources
Adrenomedullin: Exciting New Horizons
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, 2012Adrenomedullin is a peptide initially isolated from pheochromocytoma. It has a wide distribution and has multiple actions in many systems including the cardiovascular, renal, endocrine, reproductive, immune, nervous and musculoskeletal systems. This is reflected in the patents.
Cheung, BMY, Tang, F
openaire +4 more sources

