Mechanism of Peptide Agonist Binding in CXCR4 Chemokine Receptor
Frontiers in Molecular Biosciences, 2022 Chemokine receptors are key G-protein-coupled receptors (GPCRs) that control cell migration in immune system responses, development of cardiovascular and central nervous systems, and numerous diseases. In particular, the CXCR4 chemokine receptor promotes
Shristi Pawnikar, Yinglong Miao
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Designer lipid-like peptides: a class of detergents for studying functional olfactory receptors using commercial cell-free systems. [PDF]
PLoS ONE, 2011 A crucial bottleneck in membrane protein studies, particularly G-protein coupled receptors, is the notorious difficulty of finding an optimal detergent that can solubilize them and maintain their stability and function. Here we report rapid production of
Karolina Corin +11 more
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A Peptide Mimetic of 5-Acetylneuraminic Acid-Galactose Binds with High Avidity to Siglecs and NKG2D. [PDF]
PLoS ONE, 2015 We previously identified several peptide sequences that mimicked the terminal sugars of complex glycans. Using plant lectins as analogs of lectin-type cell-surface receptors, a tetravalent form of a peptide with the sequence NPSHPLSG, designated svH1C ...
Laura L Eggink +4 more
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Sequence, structure and ligand binding evolution of rhodopsin-like G protein-coupled receptors: a crystal structure-based phylogenetic analysis. [PDF]
PLoS ONE, 2015 G protein-coupled receptors (GPCRs) form the largest family of membrane receptors in the human genome. Advances in membrane protein crystallization so far resulted in the determination of 24 receptors available as high-resolution atomic structures.
Steffen Wolf, Stefan Grünewald
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Structural Understanding of Peptide-Bound G Protein-Coupled Receptors: Peptide–Target Interactions
, 2023 The activation of G protein-coupled receptors (GPCRs) is triggered by ligand binding to their orthosteric sites, which induces ligand-specific conformational changes.
Ting Chen (15205) +11 more
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System-wide mapping of peptide-GPCR interactions in C. elegans
Cell Reports, 2023 Summary: Neuropeptides and peptide hormones are ancient, widespread signaling molecules that underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly by binding to G protein-coupled receptors (GPCRs).
Isabel Beets +12 more
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Biomolecules, 2021 The calcitonin and amylin receptors (CTR and AMY receptors) are the drug targets for osteoporosis and diabetes treatment, respectively. Salmon calcitonin (sCT) and pramlintide were developed as peptide drugs that activate these receptors.
Sangmin Lee
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Peptide Receptor Radionuclide Therapy [PDF]
Best Practice & Research Clinical Gastroenterology, 2004 Abstract: On their plasma membranes, cells express receptor proteins with high affinity for regulatory peptides, such as somatostatin. Changes in the density of these receptors during disease, for example, overexpression in many tumors, provide the basis for new imaging methods.
Krenning, Eric +5 more
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Two-armed molecular receptors : peptide recognition and vesicle formation driven by selective non-covalent interactions [PDF]
, 2007 This thesis presents examples for applying encoded combinatorial chemistry to trace molecular interactions between two-armed receptors and peptidic substrates that could have not been predicted by conventional means.
Grun, Jessica
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Effects of peptide on NK cell-mediated MHC I recognition
Frontiers in Immunology, 2014 The inhibitory receptors for MHC class I have a central role in controlling NK cell activity. Soon after their discovery it was found that these receptors have a degree of peptide selectivity.
Salim Iqbal Khakoo +2 more
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