Results 31 to 40 of about 507,789 (292)
Cgrp Characterization And Classification
The Scientific World Journal, 2001 The peptide CGRP is thought to be an agonist at a number of receptors including its own as well as those for adrenomedullin and amylin. CGRP is thought to act through its own receptors if it is antagonized by the truncated peptide CGRP8-37 although this ...
Ian Marshall
doaj +1 more source
, 2017 The lining of the gastrointestinal tract needs to be easily accessible to nutrients and, at the same time, defend against pathogens and chemical challenges. This lining is the largest and most vulnerable surface that faces the outside world.
Jeremy J Cottrell (19227652) +1 more
core +2 more sources
Structure-function analysis of the cloned opiate receptors: peptide and small molecule interactions
, 1996 Opiate receptors mediate the physiological actions of opioid peptides and the clinical effects of the synthetic opioid agonists and antagonists. Site-directed mutagenesis studies have revealed regions of opiate receptors that are essential for ligand ...
Blake, Allan D. +2 more
core +1 more source
The TNF Receptors p55 and p75 Mediate Chemotaxis of PMN Induced by TNFα and a TNFα 36–62 Peptide
Mediators of Inflammation, 1994 The present study was performed to examine whether residues 36–62 of TNFα contain the chemotactic domain of TNFα, and whether the p55 and p75 TNF receptors are involved in TNFα induced chemotaxis.
Ø. Rekdal +5 more
doaj +1 more source
Location and nature of the residues important for ligand recognition in G-protein coupled receptors
, 2005 The overall structure of the biogenic amine subclass of the G-protein-coupled receptors, and of their ligand binding sites, is discussed with the aim of highlighting the major structural features of these receptors that are responsible for ligand ...
Bywater, Robert P.
core +1 more source
New Insights Into Peptide Cannabinoids: Structure, Biosynthesis and Signaling
Frontiers in Pharmacology, 2020 Classically, the endocannabinoid system (ECS) consists of endogenous lipids, of which the best known are anandamide (AEA) and 2 arachidonoylglycerol (2-AG), their enzyme machinery for synthesis and degradation and their specific receptors, cannabinoid ...
Agustín Riquelme-Sandoval +7 more
doaj +1 more source
Deorphanization of Novel Peptides and Their Receptors [PDF]
The AAPS Journal, 2010 Peptide hormones and neuropeptides play important roles in endocrine and neural signaling, often using G protein-coupled receptor (GPCR)-mediated signaling pathways. However, the rate of novel peptide discovery has slowed dramatically in recent years. Genomic sequencing efforts have yielded a large number of cDNA sequences that potentially encode novel
Akihiko, Ozawa +3 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Structural basis of peptide recognition and activation of endothelin receptors
Nature Communications, 2023 Endothelin receptors (ETAR and ETBR) are critical for vasoregulation and are targets for cardiovascular diseases treatment. Here, the authors offer a structural basis for peptide recognition selectivity and activation of both endothelin receptors.
Yujie Ji +12 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source