Results 51 to 60 of about 507,789 (292)

Formyl Peptide Receptors and Annexin A1: Complementary Mechanisms to Infliximab in Murine Experimental Colitis and Crohn’s Disease

Frontiers in Immunology, 2021
Non-responsiveness to anti-TNF-α therapies presents relevant rates in inflammatory bowel disease patients, presenting the need to find biomarkers involved in therapeutic efficacy.
Marina de Paula-Silva, Marina de Paula-Silva, Gustavo Henrique Oliveira da Rocha, Milena Fronza Broering, Maria Luíza Queiroz, Silvana Sandri, Rodrigo Azevedo Loiola, Sonia Maria Oliani, Andrea Vieira, Mauro Perretti, Sandra Helena Poliselli Farsky   +10 more
doaj   +1 more source

Mimotopes of the nicotinic receptor binding site selected by a combinatorial peptide library

, 2001
Peptide libraries allow selecting new molecules, defined as mimotopes, which are able to mimic the structural and functional features of a native protein.
BRACCI LUISA, LOZZI LUISA, NERI PAOLO, PINI A., LELLI BARBARA   +4 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Effect of free thymol on the differential gene expression in gastric mucosa of the young pig

, 2014
Thymol is the most common molecule in thyme and has been proposed as an oral alternative to antibiotics in the feed of pigs and broilers. The knowledge of the in vivo physiological effects of thymol on tissues is limited, particularly its impact on the ...
BOATTO, Gianpiero, Priori D, Bosi P, Trevisi P., Nieddu M, Colombo M, Gandolfi G   +6 more
core   +2 more sources

Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides

Frontiers in Endocrinology, 2012
The enzymatic pathways leading to the synthesis of bioactive steroids in the brain are now almost completely elucidated in various groups of vertebrates and, during the last decade, the neuronal mechanisms involved in the regulation of neurosteroid ...
Jean-Luc eDo-Rego, Jae Young eSeong, Delphine eBurel, Jérôme eLEPRINCE, David eVaudry, David eVaudry, Van eLuu-The, Marie-Christine eTonon, Marie-Christine eTonon, Kazuyoshi eTsutsui, Georges ePelletier, Hubert eVaudry, Hubert eVaudry   +12 more
doaj   +1 more source

Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules

Frontiers in Immunology, 2023
Major Histocompatibility Complex class I (MHC-I) molecules display self, viral or aberrant epitopic peptides to T cell receptors (TCRs), which employ interactions between complementarity-determining regions with both peptide and MHC-I heavy chain ...
Georgia F. Papadaki, Georgia F. Papadaki, Omar Ani, Tyler J. Florio, Tyler J. Florio, Michael C. Young, Michael C. Young, Julia N. Danon, Julia N. Danon, Yi Sun, Yi Sun, Devin Dersh, Nikolaos G. Sgourakis, Nikolaos G. Sgourakis   +13 more
doaj   +1 more source

Peptide agonists of the thrombopoietin receptor [PDF]

Stem Cells, 1998
We have screened a variety of L-amino acid peptide libraries against the extracellular domain of the human thrombopoietin (HuTPO) receptor, c-Mpl. A large number of peptide ligands were recovered and categorized into two families. Peptides from each family compete with the binding of HuTPO and with the binding of peptides from the other familiy ...
W J, Dower, S E, Cwirla, P, Balasubramanian, P J, Schatz, D P, Baccanari, R W, Barrett   +5 more
openaire   +2 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Structural insights into prolactin-releasing peptide receptor signaling and G-protein coupling selectivity

Cell Reports
Summary: Prolactin-releasing peptide receptor (PrRPR), a notable member of the class A peptide-GPCR (G-protein-coupled receptor) family, regulates diverse physiology functions upon activation by PrRP.
Zhangsong Wu, Chen Qiu, Yiming Liu, Xiaoyi Yan, Qiaohui Li, Shirui Jiang, Jun Xu, Xin Pan, Fang Ye, Zhiyi Zhang, Peiruo Ning, Binghao Zhang, Lezhi Xu, Bangning Cheng, Xufu Xiang, Chungen Qian, Yang Du, Geng Chen   +17 more
doaj   +1 more source